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Method for preparing micro-fluidic chip by combining digital cutting machine processing with liquid molding method

A microfluidic chip, using digital technology, applied in metal processing, laboratory containers, chemical instruments and methods, etc., can solve problems such as the preparation method of microfluidic chips that have not yet been seen, and achieve high promotion and application capabilities, The effect of high use value and low cost

Inactive Publication Date: 2019-02-12
DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In actual operation, the processing process is simple and fast, and microfluidic channel chips with arbitrary curved surfaces can be prepared. There is no method for preparing microfluidic chip with arbitrary curved surfaces.

Method used

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  • Method for preparing micro-fluidic chip by combining digital cutting machine processing with liquid molding method
  • Method for preparing micro-fluidic chip by combining digital cutting machine processing with liquid molding method
  • Method for preparing micro-fluidic chip by combining digital cutting machine processing with liquid molding method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Use AutoCAD software to design different graphics templates and save them as R 12 / R 14 Import the .DXF format file into the digital cutting machine software. The PVC lettering paper and the cutting coordinate backing plate are closely attached and the remaining internal air bubbles are driven away, and then input into the cutting machine for cutting. The cutting speed is 5cm / s, and the cutting depth is 13. After taking it out, a PVC hollow mask is obtained. Use TMCS to silanize silicon wafers, glass, flat PDMS, and paper substrates for 1 minute, then attach the PVC hollow mask to the above-mentioned silanized substrates and drive away the remaining internal air bubbles, then place them in a plasma cleaning machine for use High gear for plasma treatment for 10 minutes. Take out the substrate after plasma treatment, tear off the PVC hollow mask, and use a pipette gun to add 40% aqueous glycerin solution to the hydrophilic pattern area to prepare hydrophilic models on d...

Embodiment 2

[0032] Use AutoCAD software to design the straight channel template of the microfluidic chip and save it as R 12 / R 14 Import the .DXF format file into the digital cutting machine software. The PVC lettering paper and the cutting coordinate pad are closely attached and the residual air bubbles inside are driven away, and then input into the cutting machine for cutting. The cutting speed is 10cm / s, and the cutting depth is 13. After taking it out, a PVC hollow mask is obtained. Use TMCS to perform silanization treatment on the silicon wafer substrate for 1min. After the PVC hollow mask is closely attached to the silanized substrate and the remaining internal air bubbles are driven away, place it in a plasma cleaning machine and use the High gear for plasma treatment for 10 minutes. . Take out the substrate after plasma treatment, tear off the PVC hollow mask, and rinse the surface of the substrate repeatedly with propyl lactate, ethanol and deionized water until there is no r...

Embodiment 3

[0037] Use AutoCAD software to design the microfluidic gradient mixing template and save it as R 12 / R 14 Import the .DXF format file into the digital cutting machine software. The PVC lettering paper and the cutting coordinate pad are closely attached and the residual air bubbles inside are driven away, and then input into the cutting machine for cutting, the cutting speed is 1cm / s, the cutting depth is 10, and the PVC hollow mask is obtained after taking it out. Use TMCS to perform silanization on the PS substrate for 1 min. After the PVC hollow mask is closely attached to the silanized PS substrate and the remaining internal air bubbles are driven away, place it in a plasma cleaning machine and use the High gear for plasma treatment for 2 minutes. . Take out the substrate after plasma treatment, tear off the PVC hollow mask, rinse the surface of the substrate repeatedly with propyl lactate, ethanol and deionized water until there is no residual glue on the surface, and us...

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Abstract

The invention provides a method for preparing a micro-fluidic chip by combining digital cutting machine processing with a liquid molding method. The method is performed according to the following steps of processing PVC lettering paper by a digital cutting machine to obtain a patterning PVC hollow mask; performing tight attaching with a substrate; after hydrophilic treatment, obtaining a hydrophilic pattern corresponding to the PVC hollow mask on the substrate; then, using a glycerol water solution to from a liquid mold with a certain height on the hydrophilic pattern; covering the whole substrate by liquid PDMS at a certain proportion; after heating solidification, peeling down PDMS; performing hole forming bonding to obtain the micro-fluidic chip. The method has the advantages that the processing cost of the micro-fluidic chip can be reduced; the preparation time is reduced; the chip passage surface smoothness degree is improved; in addition, the curve surface arc-shaped micro-fluidic passage can be produced and processed. The method has the characteristics that the technical flow process is simple; the reagent consumption is low; the cost is low; use value is high; the high popularization and application capability is realized.

Description

technical field [0001] The invention belongs to the field of preparation of microfluidic chips, in particular to a method for preparing microfluidic chips by using digital cutting machine processing combined with a liquid-plastic method. Background technique [0002] Microfluidic chip laboratory refers to the integration of basic operating units such as sample preparation, separation, and detection involved in the fields of biology and chemistry into a chip of several square centimeters to complete the interaction of different trace biological and chemical samples. Or reaction process, and a technique for separating and analyzing its products. The photolithography method is a traditional microfluidic chip laboratory preparation method. The photoresist is processed by UV exposure to form a mold. The process includes photoresist spin coating, pre-baking, exposure, film washing, post-baking, and film hardening. The entire processing process is cumbersome and consumes a lot of ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01L3/00B26D3/00
CPCB01L3/502707B01L2300/0829B26D3/00
Inventor 陆瑶颜世强王舒婷白雪李林梅林炳承
Owner DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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