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Olealignan in purslane and its extraction and separation method and its application

A separation method and technology of purslane, which are applied in the directions of ether separation/purification, organic chemistry, antitumor drugs, etc., can solve the problem of low structural novelty, and achieve the effects of environmental protection of the process method, simple and fast operation method

Active Publication Date: 2021-06-15
LIAONING UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] At present, most of the chemical components isolated from purslane are known, and the structural novelty is low. Therefore, the development and isolation of new compounds in purslane are urgently needed

Method used

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  • Olealignan in purslane and its extraction and separation method and its application
  • Olealignan in purslane and its extraction and separation method and its application
  • Olealignan in purslane and its extraction and separation method and its application

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Embodiment 1

[0030] The present invention provides new compound, molecular formula is C 18 h 16 o 4 , named as olealignan chemical structure shown in Figure 10.

[0031] Described new compound is called olealignan according to structure, and table 1 is the NMR data of this new compound: 1 H-NMR with 13 C-NMR in deuterated DMSO.

[0032]

[0033]

[0034] The structural identification of the compounds of the present invention can be referred to Figure 1-10 .

[0035] Oleralignan: Yellow-green powder, easily soluble in methanol. After spotting the sample on the silica gel thin-layer plate, spray the ferric chloride test solution and the spot turns blue. UV(MeOH)λ max : 291,236nm. IR v max 3393,2925,2850,1600, 1515,1478,1256,1203,1159,1125,1021,859,790,762cm -1 . HRESI(+)TOFMS gives m / z: 297.1092[M+H] + The quasi-molecular ion peak has a molecular weight of 296.1043. combine 1 H-NMR, 13 According to C-NMR and DEPT data, it is speculated that the possible molecular form...

Embodiment 2

[0046] Embodiment 2 is basically the same as Embodiment 1, and its difference is:

[0047] Water is 8 times in step 1.

[0048] Step 6: Acetonitrile: 0.1% (volume percent) formic acid (48:52, v:v) was used as the mobile phase, and the detection wavelength was 210nm, 280nm, and the new compound of the present invention was obtained by separation with a purity of 93%.

Embodiment 3

[0050] Embodiment 3 is basically the same as Embodiment 1, and its difference is:

[0051] Water is 16 times in step 1.

[0052] In step 6, acetonitrile: 0.1% (volume percent) formic acid (50:50, v:v) was used as the mobile phase, and the detection wavelength was 210nm, 280nm to separate and prepare the new compound of the present invention with a purity of 90%.

[0053] Obtained from embodiment 1-3: the purity measured by normalization method is 90~97.5%.

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Abstract

Oleralignan in purslane, its extraction and separation method and its application, especially relates to the new lignan compounds extracted, separated and identified from purslane and its extraction and separation method. The molecular formula of the new compound is C 18 h 16 o 4 , named olealignan. It also provides the extraction and separation method of the above-mentioned new compound, followed by decoction with water, silica gel column chromatography, polyamide column chromatography, ODS medium pressure column and Sephadex LH‑20 separation and preparation, and successfully extracted and separated a new lignan class of compounds. Its structure is identified as a new lignan compound by means of mass spectrum, carbon spectrum, hydrogen spectrum and two-dimensional nuclear magnetic spectrum analysis, which has anti-tumor and anti-oxidation effects. The new compound of the present invention and its salt or derivative can be used as Synthetic leads of other compounds and raw materials for new drug development and pharmacological activity research, used to prepare anti-tumor, anti-oxidation drugs or health products.

Description

technical field [0001] The invention relates to the field of extraction and separation of traditional Chinese medicines, in particular to new compounds extracted, separated and identified from purslane medicinal materials and their extraction and separation methods, specifically the extraction and separation method of Oleralignan (purslane lignin) in purslane and its application. Background technique [0002] Purslane (Portulaca oleracea L.), also known as amaranth, longevity vegetable, ant vegetable, is an annual herb of the family Portulacaceae. Purslane is widely distributed and rich in resources. It is one of the 78 wild plants with the same origin of medicine and food as stipulated by the Ministry of Health of my country. Purslane is recorded in the 2015 edition of "Pharmacopoeia of the People's Republic of China". It has the functions of clearing heat and detoxifying, cooling blood and stopping bleeding, and stopping dysentery. , hemorrhoids, metrorrhagia, etc. [0...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C43/23C07C41/34C07C41/36A61P35/00A61P39/06
CPCA61P35/00A61P39/06C07C43/23
Inventor 英锡相张文洁马懿飞徐浩然修芬英子瑜
Owner LIAONING UNIV OF TRADITIONAL CHINESE MEDICINE
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