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Effervescent tablets and preparation technology thereof

A technology of effervescent tablets and acid agents, which is applied in the field of effervescent tablet preparation technology, can solve problems such as inability to compress tablets, decrease in effervescent dissolution rate, cumbersome and complicated process, etc., and achieve the effects of saving manpower, reducing water and electricity, and uniform color

Inactive Publication Date: 2019-02-26
江苏汉典生物科技股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] (1) It is difficult to form when pressing tablets: effervescent tablets need to be effervescently dissolved in water before eating, and the effervescent speed generally requires within 5 minutes at room temperature. decline
[0006] (2) Sticking and punching (material sticking to the mould) when pressing tablets: In general tablets, lubricants need to be added in the material ratio, otherwise they will stick and punch and cannot be pressed into tablets, and some lubricants are used for medicine and cannot be used for food , Some of the health care products are non-water-soluble, and a large amount of insoluble floating matter or sediment will be produced when effervescently dissolved, which is very poor in sense
[0007] (3) Difficulty in tablet coloring: Effervescent tablets are generally made into various fruit flavors, one side is matched with the corresponding fruit color, and one side coloring must be solved through granulation, which makes the process cumbersome and complicated

Method used

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  • Effervescent tablets and preparation technology thereof
  • Effervescent tablets and preparation technology thereof
  • Effervescent tablets and preparation technology thereof

Examples

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preparation example Construction

[0028] The preparation process of the present invention comprises the following steps:

[0029] (1) Mixing: After taking 50% to 80% of the acid agent and all the pigments and pulverizing them through an 80 mesh sieve, they are then dissolved in a diluent accounting for 8% to 15% of the mass fraction of all materials, and mixed with a mixer for 30 minute;

[0030] (2) Drying: Place the mixed material in step (1) in an oven at 70-80°C to dry until the moisture content reaches below 3%, then take it out;

[0031] (3) Mixing: mix the semi-finished product obtained in step (2) with the remaining acid agent, the alkali agent, lactose, main ingredients, low-strength adhesive, essence, sweetener, and nutrients passed through a 30-mesh sieve;

[0032] (4) Tablet pressing: under the conditions of temperature at 18-25°C and relative humidity below 50%, use a rotary tablet press to press the tablets. The rotation speed of the tablet press is 12-20 rpm, and the pressure is 200-300KN. , s...

Embodiment 1

[0035] A kind of effervescent tablet, the quality of each material is as follows:

[0036] Citric acid 1.9g, sodium carbonate 1.2g, lactose 0.439g, fruit powder 0.2g, sorbitol 0.1g, essence 0.1g, sucralose 0.05g, nutrient 0.009g, pigment 0.002g.

[0037] The preparation technology of above-mentioned effervescent tablet, comprises the following steps:

[0038] (1) Mixing: after taking 50% of citric acid and all the pigments and pulverizing through an 80 mesh sieve, dissolve them in water accounting for 15% of the mass fraction of all materials, and mix with a mixer for 30 minutes;

[0039] (2) Drying: Place the mixed material in step (1) in an oven at 70°C to dry until the moisture reaches 2.5% and then take it out;

[0040] (3) Mixing: mix the semi-finished product obtained in step (2) with the remaining citric acid, sodium carbonate passed through a 30-mesh sieve, lactose, fruit powder, sorbitol, essence, sucralose, and nutrients;

[0041] (4) Tablet pressing: temperature i...

Embodiment 2

[0059] A kind of effervescent tablet, the quality of each material is as follows:

[0060] Citric acid 2g, sodium carbonate 1.3g, lactose 0.359g, cereal powder 0.1g, sorbitol 0.08g, essence 0.05g, sucralose 0.08g, acesulfame potassium 0.02g, nutrient 0.01g, pigment 0.001g.

[0061] The preparation technology of above-mentioned effervescent tablet, comprises the following steps:

[0062] (1) Mixing: after getting 65% of citric acid and all the pigments and pulverizing through an 80 mesh sieve, dissolve them in water accounting for 12% of the mass fraction of all materials, and mix with a mixer for 30 minutes;

[0063] (2) Drying: Place the mixed material in step (1) in an oven at 75°C to dry until the moisture reaches 2.8%, then take it out;

[0064] (3) Mixing: mix the semi-finished product obtained in step (2) with the remaining citric acid, sodium carbonate passed through a 30-mesh sieve, lactose, grain powder, sorbitol, essence, sucralose, acesulfame potassium, and nutrien...

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Abstract

The invention discloses effervescent tablets and a preparation technology thereof, and belongs to the technical field of effervescent tablet preparation. The preparation technology specially adopts avertical compression technology and comprises steps of mixing, drying, blending and preforming. By adjusting the reasonable quantity of an acid agent and an alkaline agent and adopting a low-strengthbinder, usage of a non-soluble lubricating agent is avoided, steps of pelletizing and granulation in wet granulation and dry granulation are omitted, so that the technology is simplified, labor, time,water and electricity are saved by 50% or higher, and production cost is greatly reduced.

Description

technical field [0001] The invention relates to the technical field of preparation of effervescent tablets, in particular to a preparation process of effervescent tablets. Background technique [0002] There are three methods for preparing effervescent tablets: wet granulation, dry granulation, and direct compression. Among them, wet granulation consists of soft materials mixed with powders of raw materials and binders, and drying of granules. However, the soft material is made using a trough mixer, and the soft material is wet granulated by a swaying granulator, and then dried into dry granules in a drying oven. This method has low output, high strength, serious pollution, and long production cycle. The equipment occupies a large area. Dry granulation is to press the powder mixture into large tablets and then crush and granulate to make granules of the required size. It is suitable for moisture-sensitive materials, and the "dust" of tableting is serious, which is easy to c...

Claims

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Application Information

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IPC IPC(8): A23L2/40A23L2/395
CPCA23L2/395A23L2/40
Inventor 丁向东
Owner 江苏汉典生物科技股份有限公司