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Composition for inhibiting or killing porphyromonas gingivalis and/or streptococcus muntans bacteria and use thereof

A technology of Porphyromonas gingivalis and Streptococcus gingivalis, which is applied in the manufacture of medicines for inhibiting or killing Porphyromonas gingivalis and Streptococcus transsaccharis In the field of composition, it can solve problems such as unstable active ingredients, great differences in active ingredients, and slow growth, and achieve the effects of effectively inhibiting or killing growth, low inhibitory concentration, and short culture period

Inactive Publication Date: 2019-02-26
SYI BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, the growth and cultivation methods of Cinnamomum camphora are very different for the active components of Cinnamomum camphora. Although the fruiting body of wild Cinnamomum camphora has the highest and most active components, wild Cinnamomum camphora is not easy to obtain and expensive, which is not conducive to mass production; and Basswood artificially cultivated camphor fruiting body grows very slowly, the cultivation time needs to be as long as 2 to 3 years, and it will vary according to climate change, the active ingredient is unstable and the cost is high

Method used

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  • Composition for inhibiting or killing porphyromonas gingivalis and/or streptococcus muntans bacteria and use thereof
  • Composition for inhibiting or killing porphyromonas gingivalis and/or streptococcus muntans bacteria and use thereof
  • Composition for inhibiting or killing porphyromonas gingivalis and/or streptococcus muntans bacteria and use thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example 1

[0033] Preparation Example 1 Preparation of Brain Heart Infusion Agar (BHI agar) and Supplemented Brain Heart Infusion Agar (sBHI agar)

[0034] Add 5.2 grams (g) of brain-heart infusion medium to water to make the volume 100 milliliters (mL), sterilize it and place it at 50°C to become the brain-heart infusion medium; add 5.2 g of brain-heart infusion The culture medium and 0.5g of yeast extract are added to water to make the volume 100mL, after sterilization, place at 50°C, and add 5% defibrinated sheep blood, which is the medium for supplementing brain heart infusion.

preparation example 2

[0035] Preparation Example 2 Preparation of Brain Heart Infusion Broth (BHI Broth) and Supplemented Brain Heart Infusion Broth (sBHI Broth)

[0036] Add 3.7g of brain heart infusion culture solution to water to make the volume 100mL, sterilize and cool to room temperature to obtain brain heart infusion culture solution; extract 3.7g of brain heart infusion culture solution and 0.5g of yeast The solution was added to water to make the volume 100mL, after sterilization and cooled to room temperature, 0.05g of cysteine ​​hydrochloride, 1mL of hemin solution and 20 microliters (μL) of vitamin K1 were added. That is to supplement the culture medium of brain heart infusion.

preparation example 3

[0037] The cultivation of preparation example 3 Cinnamomum camphora thin hole mycelium

[0038] Obtain the fruiting body from the wild Antrodia camphorata wood, separate and purify the Antrodia camphorata strains by the existing technology, use the culture solution containing 2% glucose, 2% malt extract and 0.5% yeast extract to carry out "seed bacteria" culture, and then carry out solid-state Cultivate (solid medium contains 55% buckwheat, 44% water, 0.6% malt extract, 0.4% casein peptone), cultivate at a temperature of 25°C and under dark light for 60 days, and obtain thin pores of camphor The mycelium is dried to obtain the dry powder of the thin-pored mycelium of camphor camphora.

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Abstract

The invention provides a composition for inhibiting or killing porphyromonas gingivalis and / or streptococcus muntans bacteria and a use thereof. The composition contains Antrodia cinnamomea mycelium extract in a dosage for effectively inhibiting or killing porphyromonas gingivalis and / or streptococcus muntans bacteria and an acceptable carrier. The invention also provides a use of the compositionin preparation of a medicament for inhibiting or killing porphyromonas gingivalis and / or streptococcus muntans bacteria and a use of the composition in preparation of a medicament for reducing or treating diseases caused by porphyromonas gingivalis and / or streptococcus muntans bacteria. The Antrodia cinnamomea mycelium has effects of inhibiting or killing porphyromonas gingivalis and / or streptococcus muntans bacteria, can be used for inhibiting or killing porphyromonas gingivalis and / or streptococcus muntans bacteria in various industries and has the advantages of no side effect, easy preparation and low preparation cost.

Description

technical field [0001] The invention relates to a composition for inhibiting or killing Porphyromonas gingivalis and Streptococcus mutans. The present invention also relates to a use of the composition for manufacturing medicines for inhibiting or killing Porphyromonas gingivalis and Streptococcus transsaccharicus. The present invention also relates to a use of the composition for the manufacture of a medicament for alleviating or treating diseases derived from Porphyromonas gingivalis and Streptococcus transsaccharides. Background technique [0002] Periodontal bacteria (periodontal bacteria) infection of the gum tissue or the alveolar bone of the tooth is the main cause of periodontal disease. Currently known pathogenic periodontal bacteria mainly include Actinobacillus actinomycetemcomitans (Aa), Porphyromonas gingivalis (Pg), Fusobacterium nucleatum Streptococcus mutans and Bacteroides forsythus (Bf). The glycoprotein in the saliva in the oral cavity will form a thin ...

Claims

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Application Information

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IPC IPC(8): A61K36/07A61P1/02A61P31/04A61P31/02A61P9/00A61P31/00A61P9/10A61P9/14A61P7/02A61P37/02A61P19/02A61P29/00A61P17/06A61P1/00A61Q11/00A61Q17/00A23L2/38A23L2/52
CPCA61Q11/00A61Q17/005A23L2/38A23L2/52A23L31/00A23L33/00A23L33/10A61K36/07A23V2002/00A61K2236/33A23V2200/312A23V2200/324A23V2200/326A23V2250/208
Inventor 连秀屘陈家章张筱君曾景瑞
Owner SYI BIOTECH CO LTD
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