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Acne-removal concentrate and application thereof

A concentrate and anti-acne technology, which is applied in the field of anti-acne concentrate and its application, can solve the problems of not providing in vivo and in vitro test data, not being able to determine the amount of addition, and not involving the inhibition of the population effect of Propionibacterium acnes

Active Publication Date: 2019-03-01
仙婷(广州)科技研发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] Chinese patent CN105796624A A method of improving the health of the surface of organisms only involves a method of improving the health of the surface of organisms, and does not provide specific in vivo and in vitro test data. In other words, it is impossible to determine how much to add to be effective
[0014] Chinese patent CN103462881B, a composition that can promote the microecological balance of the skin and its preparation method only involves the regulation of the microecological balance of the skin, and does not involve the efficacy of inhibiting the quorum effect of Propionibacterium acnes
[0015] Chinese patent CN105997593A, a prebiotic functional formula that regulates the imbalance of skin flora and relieves eczema, only involves the prevention and regulation of flora imbalance in dermatitis eczema lesions, inhibits the reproduction of potential pathogenic bacteria such as Staphylococcus aureus, and promotes bifidus The growth of probiotics such as Bacillus, not involved in the efficacy of inhibiting the quorum effect of P. acnes

Method used

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  • Acne-removal concentrate and application thereof
  • Acne-removal concentrate and application thereof
  • Acne-removal concentrate and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] The preparation method of the anti-acne concentrate of the present embodiment is as follows:

[0042] (1) Lactobacillus was inoculated into an aqueous solution of pine leaf extract with an inoculation amount of 800cfu / g and fermented at 37°C for 48 hours to obtain a fermentation broth;

[0043] (2) Sterilize and filter the fermented liquid obtained in step (1), filter out inactivated lactobacilli and other macromolecular metabolic wastes, concentrate the obtained filtrate to obtain a concentrate, which is the acne-removing concentrate .

[0044] The preparation method of the acne-removing liquid Shanfujun of the present embodiment is as follows:

[0045] Add butanediol, water, hydroxypropyl cyclodextrin and dipropylene glycol to the anti-acne concentrate of this example, and then filter to obtain the filtrate, which is the anti-acne liquid.

Embodiment 2

[0047] The present invention combines the acne-removing concentrate with different solvents to optimize the acne-removing liquid Shanfujun (butanediol, water, hydroxypropyl cyclodextrin, dipropylene glycol, concentrated acne-removing solution) without preservatives. The optimal solvent ratio of the antiseptic, efficacy, stability and mildness of the substance), the test process is as follows in Table 1:

[0048] Table 1 compounding scheme

[0049]

[0050]

[0051] 1. Stability test:

[0052] Test group 1: Passed the stability test but failed the corrosion test.

[0053] Test group 2: Passed the stability test but failed the anticorrosion test.

[0054] Test group 3: Passed the stability test and passed the anti-corrosion test.

[0055] Test group 4: failed the stability test but passed the anticorrosion test.

[0056] Test group 5: Passed the stability test and passed the anticorrosion test.

[0057] Test group 6: Passed the stability test and passed the anti-corro...

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Abstract

The invention provides an acne-removal concentrate. The acne-removal concentrate is prepared by using the method comprising the steps that 1, lactobacilli are inoculated into pinus densiflora leaf extracts for fermentation, and fermentation liquor is obtained; 2, the fermentation liquor obtained in the step 1 is sterilized and filtered, and filter liquor is obtained; the filter liquor is concentrated to obtain the acne-removal concentrate. The invention further provides acne-removal lotion Shanfujun QUORASTOP and acne-removal cleansing lotion. The acne-removal concentrate, the acne-removal lotion Shanfujun and the acne-removal cleansing lotion can effectively inhibit the population effect of propionibacterium acnes and can effectively balance microorganisms, so that the effect of treatingacne is achieved. A volunteer uses a product containing 2% of Shanfujun, and under the conditions that only proliferation of the propionibacterium acnes is stopped without killing all propionibacterium acnes, and the bacterial drug resistance cannot be generated, acne skin can be effectively treated.

Description

technical field [0001] The invention specifically relates to a concentrate for removing acne and its application. Background technique [0002] Propionibacterium acnes (scientific name: Propionibacterium acnes) is a relatively slow-growing typical Gram-positive anaerobic bacteria (rod-shaped) that is closely related to the skin disease acne. It belongs to the normal flora of the skin and generally resides in the hair follicles and sebaceous glands of the skin. As adolescents mature, horn plugs appear at the mouth of the hair follicles, and the secretion function of the sebaceous glands also increases significantly. Because sebum contains more fatty acids and other components, it is suitable for the growth and reproduction of P. acnes, thus becoming one of the most important causes of acne. It is traditionally believed that Propionibacterium acnes is the main bacterium that causes acne, so the method used to treat acne is to directly kill Propionibacterium acnes. [0003] H...

Claims

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Application Information

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IPC IPC(8): A61K8/9767A61K8/34A61K8/73A61Q19/00A61Q17/00A61P17/10
CPCA61K8/345A61K8/738A61K2800/85A61Q17/005A61Q19/00A61K8/9767A61P17/10
Inventor 蒲思凯陈月云周雯符毅敏
Owner 仙婷(广州)科技研发有限公司
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