A kind of anti-acne concentrate and its application
A concentrated and acne-removing technology, applied to acne-removing concentrates and their application fields, can solve the problems of uncertainty about how much to be added, not involving the inhibition of the colony effect of Propionibacterium acnes, and not providing in vivo and in vitro test data, etc. Colony effects, effects of balancing the microbiome
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Embodiment 1
[0041] The preparation method of the anti-acne concentrate of the present embodiment is as follows:
[0042] (1) Lactobacillus was inoculated into an aqueous solution of pine leaf extract with an inoculation amount of 800cfu / g and fermented at 37°C for 48 hours to obtain a fermentation broth;
[0043] (2) Sterilize and filter the fermented liquid obtained in step (1), filter out inactivated lactobacilli and other macromolecular metabolic wastes, concentrate the obtained filtrate to obtain a concentrate, which is the acne-removing concentrate .
[0044] The preparation method of the acne-removing liquid Shanfujun of the present embodiment is as follows:
[0045] Add butanediol, water, hydroxypropyl cyclodextrin and dipropylene glycol to the anti-acne concentrate of this example, and then filter to obtain the filtrate, which is the anti-acne liquid.
Embodiment 2
[0047] The present invention combines the acne-removing concentrate with different solvents to optimize the acne-removing liquid Shanfujun (butanediol, water, hydroxypropyl cyclodextrin, dipropylene glycol, concentrated acne-removing solution) without preservatives. The optimal solvent ratio of the antiseptic, efficacy, stability and mildness of the substance), the test process is as follows in Table 1:
[0048] Table 1 compounding scheme
[0049]
[0050]
[0051] 1. Stability test:
[0052] Test group 1: Passed the stability test but failed the corrosion test.
[0053] Test group 2: Passed the stability test but failed the anticorrosion test.
[0054] Test group 3: Passed the stability test and passed the anti-corrosion test.
[0055] Test group 4: failed the stability test but passed the anticorrosion test.
[0056] Test group 5: Passed the stability test and passed the anticorrosion test.
[0057] Test group 6: Passed the stability test and passed the anti-corro...
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