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A traditional Chinese medicine oral liquid for preventing and treating poultry gas heat syndrome and its preparation method

A technology of traditional Chinese medicine oral liquid and heat storage, which is applied to medical preparations with non-active ingredients, medical preparations containing active ingredients, antipyretics, etc., which can solve the problem of slow recovery of chicken feed intake and greater impact on breeding benefits , long physical recovery period and other issues, to achieve better heat-clearing effect, strong quality controllability, and improvement of clinical symptoms

Active Publication Date: 2021-06-04
济南亿民动物药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In practical application, it is found that after taking Shuanghuanglian oral liquid, the fever of sick chickens is slow, the recovery of feed intake of chickens is also slow, and the recovery period of physical fitness is long, which has a great impact on breeding benefits. Therefore, a substitute for Shuanghuanglian oral liquid was developed. The traditional Chinese medicine prescription is the need of the current development of Chinese veterinary medicine

Method used

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  • A traditional Chinese medicine oral liquid for preventing and treating poultry gas heat syndrome and its preparation method
  • A traditional Chinese medicine oral liquid for preventing and treating poultry gas heat syndrome and its preparation method
  • A traditional Chinese medicine oral liquid for preventing and treating poultry gas heat syndrome and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Example 1: Screening experiment for the best prescription of a traditional Chinese medicine oral liquid for preventing and treating poultry qi-heat syndrome

[0025] 1. Materials and methods

[0026] 1.1 Materials

[0027] SPF chicken: 19 days old, purchased from Shandong Haotai Breeding Co., Ltd.

[0028] Strain: Avian Escherichia coli strain E.coli c84008 (No. CVCC2941), purchased from China Veterinary Drug Control Institute and preserved by Poultry Research Institute of Shandong Academy of Agricultural Sciences.

[0029] SPF Chicken Breeding Isolator: Product of Suzhou Fengshi Experimental Animal Equipment Co., Ltd.

[0030] Experimental drug: prepare 3 traditional Chinese medicine prescriptions as candidate prescriptions, and make 1000ml water decoction according to the following prescriptions.

[0031] Test recipe 1: gypsum 200g, gardenia 100g, Folium 100g, scutellaria baicalensis 100g, forsythia 60g, Anemarrhena 60g.

[0032] Test recipe two: Daqingye 100g, Ga...

Embodiment 2

[0075] Embodiment 2: Research on antibacterial effect in vitro

[0076] 1 Materials and methods

[0077] 1.1 Strains

[0078] Staphylococcus aureus (CICC 10307), Escherichia coli (CICC 10302), and Salmonella enteritidis (CICC 24119), the lyophilized products of the above experimental strains were purchased from the China Industrial Microbiology Culture Collection Management Center, frozen, and passaged before the test to cultivate. 1.2 Test method

[0079] Inoculate Staphylococcus aureus, Escherichia coli, and Salmonella enteritidis cultured at 37°C for 24 hours in the broth, place them in an ordinary incubator at 37°C for 24 hours, and count the bacteria by turbidimetric method. 10 6 cfu / ml bacteria solution for use. The test drug (provided in Example 1), Shuanghuanglian oral liquid (positive control) is carried out serial two-fold gradient dilution with broth by 10% (200mg crude drug / ml) as the starting point, and added successively in the 96-well cell culture plate, 0....

Embodiment 3

[0084] Embodiment 3: research on antipyretic effect

[0085] 1 Materials and methods

[0086] 1.1 Experimental animals SPF grade Wistar rats (half male and half female, body weight 180-220 g), provided by the Experimental Animal Center of Shandong University, experimental animal license number: SCXK (Lu) 2013 0009.

[0087] 1.2 Test method

[0088] Take 60 SPF-grade Wistar rats and raise them in a constant temperature laboratory environment. Before modeling, measure the anal temperature of each group of rats in the morning and evening every day, and mark the thermometer at 3cm behind the probe to ensure that the thermometer is inserted every time. Uniform length in animals. The measurement time was 9:00 am and 2:00 pm for 5 consecutive days. Rats whose body temperature was between 36.6°C and 38.0°C and whose continuous body temperature change was less than 0.3°C were selected, and the average value was taken as the normal basal body temperature.

[0089] Divide into 5 grou...

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Abstract

The invention discloses a traditional Chinese medicine oral liquid for preventing and treating poultry gas heat syndrome and a preparation method thereof. The traditional Chinese medicine oral liquid is prepared from the following raw materials: raw gypsum, gardenia, Folium Folium, scutellaria baicalensis, forsythia and Anemarrhena. Its formula is refined. Compared with Shuanghuanglian Oral Liquid, it can lower body temperature faster, relieve various discomfort symptoms caused by elevated body temperature, restore appetite faster, and increase food intake. It can be used to treat qi heat accumulation Fever, lethargy, loose feathers, decreased feed intake, etc. The traditional Chinese medicinal material adopted in the invention is easy to obtain, simple in preparation method, strong in quality controllability, stable in clinical effect, convenient and safe in use.

Description

technical field [0001] The invention belongs to the technical field of veterinary traditional Chinese medicine preparations, and in particular relates to a traditional Chinese medicine oral liquid for preventing and treating poultry gas heat syndrome. Background technique [0002] Excessive heat syndrome of poultry qi is a common clinical symptom caused by warm and heat pathogens. Fever, cough, listlessness, loose feathers, decreased feed intake, etc. can be seen. [0003] At present, the treatment for high fever in poultry is mainly: the use of antipyretic and analgesic drugs, antiviral drugs, antibiotics and traditional Chinese medicines. The use of a large number of antibiotics has caused serious problems of drug resistance and multi-drug resistance in poultry, and the trend of multiple pathogenic bacteria infections has aggravated, and the intestinal flora of poultry is seriously imbalanced. With the prohibition of conventional antiviral western medicine, there is no an...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8964A61K9/08A61P29/00A61K33/06
CPCA61K9/0095A61K33/06A61K36/195A61K36/315A61K36/539A61K36/634A61K36/704A61K36/744A61K36/855A61K36/8964A61K47/12A61K2236/331A61K2236/39A61P29/00A61K2300/00
Inventor 冉蓉王林杨艳艳吴雪旖黄艳王涛
Owner 济南亿民动物药业有限公司
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