Plugging device
A technology of occluder and head, which is applied in medical science, surgery, etc., can solve the problem of not being able to effectively promote the endothelialization of the occluder, and achieve the effect of avoiding blood washing away and promoting endothelialization for a long time
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Embodiment 1
[0082] Mix 3 g of racemic polylactic acid with a weight average molecular weight of 3W, maleic anhydride, and BPO at a molar ratio of 1:5:0.05, and vacuum-dry at room temperature to constant weight, then react at 100°C for 10 h under nitrogen protection, and then The synthesized product was separated and purified twice using a chloroform-ether co-precipitation system, and the resulting precipitate was dried under vacuum for 12 hours to obtain maleic anhydride-modified polylactic acid with a yield of 92%. Under the condition of stirring, 6g of polylactic acid modified by maleic anhydride was dissolved in 20mL of tetrahydrofuran, and under ice-bath conditions, excess ethylenediamine (20ml ) solution. After the dropwise addition was completed, react at room temperature for 1 h. After the reaction is complete, use THF-H 2 The O co-precipitation system was separated and purified, and then the precipitate was vacuum-dried to constant weight at room temperature to obtain aminated p...
Embodiment 2
[0089] Add 28.27g of lecithin, 14.4g of L-lactide, and 0.05g of stannous isooctanoate into the reaction bottle, stir evenly, control the reaction temperature at 120°C, and react in vacuum for 36 hours to obtain a prepolymer. The molecular weight of the prepolymer is 1000, 100% yield. Dissolve 30 g of the obtained prepolymer in 100 mL of toluene, add 0.04 g of stannous octoate, then drop into 20 mL of toluene solution of hexamethylene diisocyanate (15.3 g) under nitrogen, and react at 120 ° C for 7 h . Using a toluene-ethanol co-precipitation system, the precipitate is dried to constant weight under vacuum conditions to obtain lecithin-modified polyurethane with a yield of 90%. The Fourier transform infrared data of lecithin modified polyurethane is: [FTIR: 970cm -1 (-N(CH3)), 1528cm -1 (-NH)]
[0090] Lecithin-modified polyurethane is prepared into lecithin-modified polyurethane braided yarn by extruder, and lecithin-modified polyurethane is prepared into lecithin-modified...
Embodiment 3
[0096] Add 28.27g of phosphatidylcholine, 14.4g of lactide, and 0.05g of stannous isooctanoate into the reaction flask respectively, stir evenly, control the reaction temperature at 120°C, and react in vacuum for 36 hours to obtain a prepolymer. The molecular weight of the prepolymer is 1000, 100% yield. Dissolve 30 g of the obtained prepolymer in 100 mL of toluene, add 0.04 g of stannous octoate, then drop into 20 mL of toluene solution of hexamethylene diisocyanate (15.3 g) under nitrogen, and react at 120 ° C for 7 h . Using a toluene-ethanol co-precipitation system, the precipitate was dried to constant weight under vacuum conditions to obtain phosphatidylcholine-modified polylactic acid with a yield of 90%. The infrared data of polylactic acid modified by phosphatidylcholine is: [FTIR: 970cm -1 (-N(CH3)), 1540cm -1 (-NH),1735cm -1 (-C=O)].
[0097] Phosphatidylcholine-modified polylactic acid is prepared into phosphatidylcholine-modified polylactic acid braided wire ...
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