Graphene quantum dot-rare earth up-conversion nano composite material as well as preparation method and application thereof

A graphene quantum dot, nanocomposite material technology, applied in nanotechnology, nanotechnology, analytical materials and other directions, can solve the problems that limit the improvement of the sensitivity, selectivity and reliability of fluorescent immunosensors, and achieve high crystallinity, preparation Simple method and the effect of strong fluorescence emission

Active Publication Date: 2019-03-15
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The existence of these problems greatly limits the improvement of the sensitivity, selectivity and reliability of fluorescent immunosensors

Method used

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  • Graphene quantum dot-rare earth up-conversion nano composite material as well as preparation method and application thereof
  • Graphene quantum dot-rare earth up-conversion nano composite material as well as preparation method and application thereof
  • Graphene quantum dot-rare earth up-conversion nano composite material as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Example 1: Take 2.5g of citric acid monohydrate, 1.84g of L-histidine, and 0.55g of hexamethylenediamine in a 250ml beaker, add 5mL of deionized water to fully dissolve, put them in a reaction oven, and react at 170°C for 3h. The prepared histidine-hexamethylenediamine functionalized graphene quantum dots were formulated into a solution with a concentration of 25 mg / mL, and the pH was adjusted to neutral with an appropriate amount of sodium hydroxide solution. Add 1 mL of 0.78M YCl to the reaction vessel 3 solution, 1mL 0.2M YbCl 3 solution, 1mL 0.02M ErCl 3 solution, stir evenly at 500rpm, add 20ml of the above-prepared graphene quantum dot solution dropwise under stirring, keep stirring for 30min, then slowly add 6mL of 1M NaF solution dropwise, continue stirring for 1h, then transfer the mixed solution to the reaction kettle, 180℃ water Thermal reaction 4h. Take out the reacted solution and let it stand, take the supernatant and place it in a high-speed centrifuge...

Embodiment 2

[0027] Example 2: Take 2.5g of citric acid monohydrate, 2.02g of L-histidine, and 0.23g of hexamethylenediamine in a 250ml beaker, add 5mL of deionized water to fully dissolve it, put it in a reaction oven, and react at 180°C for 2h. The prepared histidine-hexamethylenediamine functionalized graphene quantum dots were formulated into a solution with a concentration of 50 mg / mL, and the pH was adjusted to neutral with an appropriate amount of sodium hydroxide solution. Add 1 mL of 0.78M YCl to the reaction vessel 3 solution, 1mL 0.2M YbCl 3 solution, 1mL 0.02M ErCl 3 solution, stir at 650rpm evenly, add 20ml of the above-prepared graphene quantum dot solution dropwise under stirring, keep stirring for 30min, then slowly add 4mL of 1M NaF solution dropwise, continue stirring for 1h, then transfer the mixed solution to the reaction kettle, 180℃ water Thermal reaction 3h. Take out the reacted solution and let it stand, take the supernatant and put it in a high-speed centrifuge tu...

Embodiment 3

[0028] Example 3: Take 2.5g of citric acid monohydrate, 1.47g of L-histidine, and 0.41g of hexamethylenediamine in a 250ml beaker, add 5mL of deionized water to fully dissolve, put them in a reaction oven, and react at 180°C for 2h. The prepared histidine-hexamethylenediamine functionalized graphene quantum dots were formulated into a solution with a concentration of 20 mg / mL, and the pH was adjusted to neutral with an appropriate amount of sodium hydroxide solution. Add 1 mL of 0.78M YCl to the reaction vessel 3 solution, 1mL 0.2M YbCl 3 solution, 1mL 0.02M ErCl 3 solution, stir at 600rpm evenly, add dropwise 30ml of the above-prepared graphene quantum dot solution under stirring, keep stirring for 30min, then slowly add 4mL of 1M NaF solution dropwise, continue stirring for 1h, then transfer the mixed solution to the reaction kettle, 180°C water Thermal reaction 4h. Take out the reacted solution and let it stand, take the supernatant and put it in a high-speed centrifuge ...

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Abstract

The invention relates to a graphene quantum dot-rare earth up-conversion nano composite material as well as a preparation method and application thereof. The preparation method of histidine-hexamethylenediamine functionalized graphene quantum dots comprises the following steps: uniformly mixing citric acid, histidine and hexamethylenediamine at a molar ratio of 1:0.6:0.1 to 1:1.2:0.5, fully dissolving in deionized water, heating the mixture at 150-200 DEG C for reaction for 0.5-4h to obtain the histidine-hexamethylenediamine functionalized graphene quantum dots, and then preparing a compositethough in-situ hydrothermal synthesis. The prepared composite material can be used for designing an up-conversion biosensing nano platform for detecting carcino-embryonic antigen CEA.

Description

technical field [0001] The invention relates to a graphene quantum dot-rare earth up-conversion nanocomposite material and a preparation method and application thereof, belonging to the technical field of composite material preparation. Background technique [0002] Upconverting nanoparticles (UCNPs) can gradually absorb two or more low-energy photons and emit high-energy light. So far, UCNPs have become a new generation of fluorescent probes with great potential. Unlike semiconductor nanocrystals and organic dyes, UCNPs have excellent optical and chemical properties, such as small background fluorescence, good photostability, large anti-Stokes shift, and extremely low biological toxicity. However, due to the poor photon upconversion efficiency of rare earth upconversion nanomaterials prepared so far, they are limited in many applications. The photon upconversion process of lanthanide-based UCNPs is achieved by the occurrence of radiative transitions, which always require ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C09K11/02C09K11/06C09K11/85B82Y20/00B82Y30/00B82Y40/00G01N21/64
CPCB82Y20/00B82Y30/00B82Y40/00C09K11/025C09K11/06C09K11/7773C09K2211/1029G01N21/6428G01N21/6486
Inventor 李在均刘玲李瑞怡牛盼盼
Owner JIANGNAN UNIV
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