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Special polypropylene infusion bottle for ambroxol hydrochloride glucose injection

A technology of glucose injection and ambroxol hydrochloride, which is applied in the directions of transportation and packaging, packaged food, packaged item types, etc., can solve problems such as easy degradation, hidden safety hazards, and content reduction, achieve safe and reliable quality, and ensure sealing performance. , the effect of improving stability

Active Publication Date: 2021-04-16
石家庄鹏海制药股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But at present, ambroxol hydrochloride glucose injection is a large-capacity injection, and it is clinically used for direct infusion into human blood. If the relevant substances in the sample are too high, there are serious safety hazards
[0003] Ambroxol hydrochloride contains a free amino group, and the amino group and glucose may undergo Maillard reaction under high temperature conditions, that is, the amino group and the aldehyde group of glucose may undergo condensation to increase related substances. The conversion of 5-hydroxymethylfurfural makes the content of 5-hydroxymethylfurfural unqualified, thus affecting the safety of the product
In particular, high temperature sterilization, exposure to light, and long-term storage are easy to degrade, resulting in decreased content, increased related substances, or even unqualified conditions, which affect the safety of the product.

Method used

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  • Special polypropylene infusion bottle for ambroxol hydrochloride glucose injection
  • Special polypropylene infusion bottle for ambroxol hydrochloride glucose injection
  • Special polypropylene infusion bottle for ambroxol hydrochloride glucose injection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] A special polypropylene infusion bottle for ambroxol hydrochloride glucose injection, comprising a bottle body, a bottle mouth and a combination cap, the bottle body and the bottle mouth are integrally formed, and the bottle body and the bottle mouth are made of polypropylene composite material; the bottom of the bottle body Concave; the bottle mouth is provided with a combined cover; the outer surface of the combined cover is provided with a protective film;

[0029] The polypropylene composite material includes a mass ratio of (15-20): (3-5): (1-2): (1-2): (0.5-1): (0.1-0.2): (0.8-1.2) : (0.3~0.5): (1~2): (0.4~0.6) of polypropylene, polylactic acid, vegetable starch, activated carbon, tributyl citrate, antibacterial agent, hydrogenated vegetable oil, bamboo charcoal, plant saponin, poly Ethylene wax and citraconic anhydride; the antibacterial agent includes chitosan, tea polyphenol and zinc oxide with a mass ratio of (2-3):(1-2):(3-5).

Embodiment 2

[0031] A special polypropylene infusion bottle for ambroxol hydrochloride glucose injection, comprising a bottle body, a bottle mouth and a combination cap, the bottle body and the bottle mouth are integrally formed, and the bottle body and the bottle mouth are made of polypropylene composite material; the bottom of the bottle body Concave; the bottle mouth is provided with a combined cover; the outer surface of the combined cover is provided with a protective film;

[0032] The polypropylene composite material includes a mass ratio of (15-20): (3-5): (1-2): (1-2): (0.5-1): (0.1-0.2): (0.8-1.2) : (0.3~0.5): (1~2): (0.4~0.6) of polypropylene, polylactic acid, vegetable starch, activated carbon, tributyl citrate, antibacterial agent, hydrogenated vegetable oil, bamboo charcoal, plant saponin, poly Ethylene wax and citraconic anhydride; the antibacterial agent includes chitosan, tea polyphenol and zinc oxide with a mass ratio of (2-3):(1-2):(3-5).

Embodiment 3

[0034] A special polypropylene infusion bottle for ambroxol hydrochloride glucose injection, comprising a bottle body, a bottle mouth and a combination cap, the bottle body and the bottle mouth are integrally formed, and the bottle body and the bottle mouth are made of polypropylene composite material; the bottom of the bottle body Concave; the bottle mouth is provided with a combined cover; the outer surface of the combined cover is provided with a protective film;

[0035] The polypropylene composite material includes a mass ratio of (15-20): (3-5): (1-2): (1-2): (0.5-1): (0.1-0.2): (0.8-1.2) : (0.3~0.5): (1~2): (0.4~0.6) of polypropylene, polylactic acid, vegetable starch, activated carbon, tributyl citrate, antibacterial agent, hydrogenated vegetable oil, bamboo charcoal, plant saponin, poly Ethylene wax and citraconic anhydride; the antibacterial agent includes chitosan, tea polyphenol and zinc oxide with a mass ratio of (2-3):(1-2):(3-5).

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PUM

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Abstract

The invention discloses a special polypropylene infusion bottle for ambroxol hydrochloride glucose injection. By setting the bottom of the bottle body as a concave and reducing the volume of the bottle as a whole, the capacity of the polypropylene infusion bottle is reduced, thereby reducing the impact of air on the product quality. Impact; the combination cap is fixed on the bottle mouth by fusing, thereby ensuring the sealing performance of the polypropylene infusion bottle, making the quality of the injection safer and more reliable; compared with the traditional polypropylene infusion bottle, the present invention can better ensure the quality of the injection , Improve the stability of the injection, so that the appearance, pH value, visible foreign matter, related substances and content of the injection all meet the regulations within 0 to 36 months.

Description

technical field [0001] The invention relates to the field of ambroxol hydrochloride glucose injection, in particular to a special polypropylene infusion bottle for ambroxol hydrochloride glucose injection. Background technique [0002] Ambroxol hydrochloride can increase the secretion of serous glands of the respiratory mucosa and reduce the secretion of mucus glands, thereby reducing the viscosity of sputum; it can also promote the secretion of pulmonary surfactant, increase the movement of bronchial cilia, and make sputum easy to cough up. It is suitable for the following patients with acute and chronic respiratory diseases with abnormal sputum secretion and poor expectoration function, such as acute exacerbation of chronic bronchitis, acute bronchitis, bronchiectasis, bronchial asthma, and pneumonia. But ambroxol hydrochloride dextrose injection is a large-capacity injection at present, and it is clinically used for direct infusion into human blood. If the relevant substa...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61J1/05A61J1/14C08L23/12C08L67/04C08L3/02C08L91/00C08L23/06C08L5/08C08K13/04C08K7/24C08K5/11C08K3/22
CPCA61J1/05A61J1/1468C08K2003/2296C08L23/12C08L2205/035C08L67/04C08L3/02C08L91/00C08L23/06C08L5/08C08K13/04C08K7/24C08K5/11C08K3/22
Inventor 张之奎赵国庆陈俊刚冯杏芳
Owner 石家庄鹏海制药股份有限公司