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Sugar-free radix polygoni multiflori preparata granule and method for preparing same

A technology for making Shouwu and sugar-free type, which is applied in the direction of anti-toxic agents, medical formulas, and medical preparations with non-active ingredients. The effect of shortening the production cycle, increasing the molding rate, and not easy to stick

Inactive Publication Date: 2019-03-19
贵州云上苗家康养有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The traditional method of making Polygonum multiflorum is mainly traditional Chinese medicine decoction, which is inconvenient to carry and store, and the bitter taste of the decoction will reduce the compliance of patients, thus limiting the application and development of Polygonum multiflorum.
The development of traditional Chinese medicine granules has provided conditions for the development of Radix Polygoni Multiflori. However, there are some problems in the preparation methods of traditional Chinese medicine granules, such as the traditional static boiling extraction, the extraction rate is not high, and some active ingredients will be mixed with water. Steam azeotropic distillation causes the loss of components; traditional excipients also have many problems, such as sucrose is easy to absorb moisture, which makes particles prone to sticking

Method used

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  • Sugar-free radix polygoni multiflori preparata granule and method for preparing same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Embodiment 1: Take an appropriate amount of Radix Polygoni Multiflori, add 10 times the amount of 70% ethanol, heat and reflux for extraction twice, each time for 2 hours, and concentrate the filtrate into a paste with a relative density of 1.32 to obtain Radix Polygoni Multiflori Extract, in 10 parts Add auxiliary materials (wherein the ratio of lactose to mannitol is 2:1) to the Shouwu extract and mix evenly, and finally add a certain amount of 70% ethanol as a wetting agent to make a soft material. Pass through a 12-mesh sieve to make granules, dry and sieve to obtain the Shouwu sugar-free granules.

Embodiment 2

[0022] Take an appropriate amount of Radix Polygoni Multiflori, add 12 times the amount of 65% ethanol, heat and reflux to extract twice, each time for 1.9h, the filtrate is concentrated into a paste with a relative density of 1.18, and the Radix Polygoni Multiflori extract is obtained. Add excipients (the ratio of lactose to mannitol is 1:1) to the extract and mix evenly, and finally add a certain amount of 65% ethanol as a wetting agent to make a soft material, pass through 12 mesh Sieve to make granules, dry and sieve to obtain Shouwu sugar-free granules.

Embodiment 3

[0024] Take an appropriate amount of Radix Polygoni Multiflori, add 15 times the amount of 75% ethanol, heat and reflux for extraction twice, each time for 2.3 hours, and the filtrate is concentrated into a paste with a relative density of 1.24 to obtain Radix Polygoni Multiflori extract. Add excipients (wherein the ratio of lactose to mannitol is 3:1) to the extract and mix evenly, and finally add a certain amount of 73% ethanol as a wetting agent to make a soft material, pass through 12 mesh Sieve to make granules, dry and sieve to obtain Shouwu sugar-free granules.

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Abstract

The invention provides a sugar-free radix polygoni multiflori preparata granule and a method for preparing the same. The sugar-free radix polygoni multiflori preparata granule is prepared from 10 parts of radix polygoni multiflori preparata extract and 40 parts of excipients. The excipients comprise lactose and mannitol, and a proportion of the lactose to the mannitol is 2:1. The method for preparing the sugar-free radix polygoni multiflori preparata granule includes adding the excipients into the radix polygoni multiflori preparata extract and uniformly mixing the excipients and the radix polygoni multiflori preparata extract with one another to obtain mixtures; ultimately adding a certain quantity of 60-75% ethyl alcohol into the mixtures to obtain soft materials; sieving the soft materials via 12-mesh sieves; preparing granules; drying and screening the granules to obtain the sugar-free radix polygoni multiflori preparata granule. The weight of the excipients is 3.5-5 times that ofthe radix polygoni multiflori preparata extract. The 60-75% ethyl alcohol is used as a wetting agent. The sugar-free radix polygoni multiflori preparata granule and the method have the advantages thatthe sugar-free radix polygoni multiflori preparata granule comprises the uniform and stable granules, and adhesion can be prevented; the sugar-free radix polygoni multiflori preparata granule prepared by the aid of the method can be dissolved in 200 ml of hot water in 5 minutes; the extraction rate is high when radix polygoni multiflori preparata is extracted, the production cycle can be shortened while curative effects are guaranteed, and the economic benefit and the forming rate can be increased.

Description

technical field [0001] The invention belongs to the technical field of health food processing, and in particular relates to a sugar-free granule prepared from Radix Polygoni Multiflori and a preparation method thereof. Background technique [0002] Health food is a category of food, which has the commonality of general food, can regulate the functions of the human body, and is suitable for specific groups of people, but cannot treat diseases. Health (functional) food is called "health food" in European and American countries, and it is called "functional food" in Japan. The rise of my country's health (functional) food was in the late 1980s and early 1990s. After the development of the first and second generations, it will also enter the third generation, that is, health food not only requires human and animal experiments to prove that the product has certain Physiological regulation function, it is necessary to find out the structure, content, mechanism of action and stable...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/704A61K9/16A61K47/26A61P3/06A61P7/06A61P39/00A61P15/00A23L33/00
CPCA23V2002/00A61K9/1623A61K36/704A61K2236/333A61K2236/39A61K2236/51A23L33/00A61P3/06A61P7/06A61P15/00A61P39/00A23V2200/3262A23V2200/326
Inventor 陈跃州
Owner 贵州云上苗家康养有限公司
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