A targeted composition for improving mild cognitive impairment and its preparation method

Abstract

The invention belongs to the technical field of medicine, and in particular relates to a targeted composition for improving mild cognitive impairment and a preparation method thereof, comprising the following components by weight: L-carnitine 20-30%, Yizhiren extract 15% ‑30%, Ginkgo biloba extract 10‑30%, Astragalus extract 10‑30%, Cyanocobalamin 0.005‑0.02%, L‑5‑methyl‑tetrahydrofolate 0.01‑0.03%, excipients 10‑30 %, the present invention is used to improve mild cognitive impairment, and the effect is more obvious.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a targeted composition for improving mild cognitive impairment and a preparation method thereof. Background technique [0002] Mild Cognitive Impairment (MCI) refers to different degrees of cognitive decline caused by various reasons. It is a clinical state intermediate between normal aging and dementia. [0003] Mild Cognitive Impairment (MCI) is the precursor stage of Alzheimer's disease (AD). Every year, about 10-15% of MCI patients can further deteriorate and turn into AD; about 80% of them turn into AD within 6 years, so MCI is a high risk factor for developing into AD. [0004] The incidence of MCI is closely related to age. According to epidemiological surveys, the number of AD in my country is 10 million, the prevalence rate is 5.0-7.0% of the population over 65 years old, and one-third of the population over 80 years old may suffer from AD. It is reporte...

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Problems solved by technology

[0010] Prevention and Treatment of Mild Cognitive Impairment with Traditional Chinese Medicine, Zhang Tianli, An Hongmei, Chinese Journal of Traditional Chinese Medicine, Volume 33, No. 2, February 2015, studied the application of Chinese herbal medicine in the preparation of mild cognitive impairment. It has been studied that traditional Chinese medicines such as Shouwu, Epimedium, Ginseng or their components can improve the symptoms of cognitive dysfunction. , Yuanzhi), Yiqiao Lizhi Decoction (Poria 25g, Shichangpu 15g, Pinellia 10g, Chenpi 6g, Codonopsis 15g, Shouwu 15g, Rehmannia glutinosa 15g, Yizhiren 15g, Dannanxing 20g, Zhilicorice 3g ), Huatan Tongqiao Decoction, Fu Jiangzhi Yizhi Granules, Huanglian Wendan Decoction, Qingnaofushen Liquid, and the combination of traditional Chinese medicine and western medicine. Although these medicines have certain curative effects, their improvement effects are not obvious and cannot well meet the needs of patients

[0011] In recent years, the global investment in research and development of AD drugs has cost tens of millions of dollars, but the failure rate accounts for 99.6%. In the past 16 years, no new drugs have been marketed. Currently, there are only four symptomatic drugs that cannot treat the cause

[0012] Why can't the developed modern medicine research and development find effective drugs for AD? This is because the traditional mainstream drug design is aimed at a single target, and does not take into account that MIC and AD are caused by multiple etiologies

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