Method for controllably synthesizing CuS@EPO nano material through electrostatic assembling

A nano-material, EPO-PAH technology, applied in the field of inorganic nano-functional materials, can solve problems such as unusable, high temperature requirements, poor photodynamic therapy effect, etc., to achieve the effect of reducing damage, enhancing therapeutic effect, and overcoming dependence on light source

Active Publication Date: 2019-03-22
FUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Endoperoxide loading on photothermal reagents showed obvious PTT effect, but the effect of PDT treatment was not obvious, photothermal-photodynamic (PTT / PDT) synergistic therapy could not be realized, and singlet oxygen was not detected in the dark
Unable to release singlet oxygen in the dark, unable to achieve the effect of killing cancer cells, naphthalene or anthracene endoperoxide derivatives release singlet oxygen requires too high temperature, can not really be used in living conditions, photodynamic therapy poor effect

Method used

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  • Method for controllably synthesizing CuS@EPO nano material through electrostatic assembling
  • Method for controllably synthesizing CuS@EPO nano material through electrostatic assembling
  • Method for controllably synthesizing CuS@EPO nano material through electrostatic assembling

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Embodiment 1

[0022] A method for controllable synthesis of CuS@EPO nanomaterials through electrostatic assembly, comprising the following steps:

[0023] (1) Take sodium citrate and copper chloride dihydrate in a round-bottomed flask filled with deionized water, stir magnetically at room temperature for 15 minutes, then gradually add aqueous solution of sodium sulfide nonahydrate to the above solution, and react at 89 °C for 20 min, to obtain an aqueous solution containing nano-CuS, then cool, centrifuge, wash, and store at 4°C; The particle size is about 20nm, and the concentration of copper chloride dihydrate is 1mol / L;

[0024] (2) After mixing 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride and N-hydroxysuccinimide, add the carboxylated pyridone endoperoxidation synthesized in advance The aqueous solution of the product was stirred at 0°C for 1 h to carry out the activation reaction; then the polyallylamine hydrochloride after dehydrochlorination treatment was added, and t...

Embodiment 2

[0034] A method for controllable synthesis of CuS@EPO nanomaterials through electrostatic assembly, comprising the following steps:

[0035] (1) Take sodium citrate and copper chloride dihydrate in a round-bottomed flask filled with deionized water, stir magnetically at room temperature for 15 minutes, then gradually add aqueous solution of sodium sulfide nonahydrate to the above solution, and react at 95 °C for 20 min, the aqueous solution containing nano-CuS was obtained, then cooled, centrifuged, washed, and stored at 6 °C; the molar masses of sodium citrate, copper chloride dihydrate, and sodium sulfide nonahydrate were 5mol, 6mol:6mol, and the particle size of nano-CuS The diameter is about 30nm, and the concentration of copper chloride dihydrate is 1.2mol / L;

[0036] (2) After mixing 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride and N-hydroxysuccinimide, add the carboxylated pyridone endoperoxidation synthesized in advance Stir the aqueous solution at 2°C ...

Embodiment 3

[0040] A method for controllable synthesis of CuS@EPO nanomaterials through electrostatic assembly, comprising the following steps:

[0041] (1) Take sodium citrate and copper chloride dihydrate in a round-bottomed flask filled with deionized water, stir magnetically at room temperature for 15 minutes, then gradually add aqueous solution of sodium sulfide nonahydrate to the above solution, and react at 90 °C for 20 min, to obtain an aqueous solution containing nano-CuS, then cooled, centrifuged, washed, and stored at 10°C; The diameter is about 20nm, and the concentration of copper chloride dihydrate is 2mol / L;

[0042] (2) After mixing 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride and N-hydroxysuccinimide, add the carboxylated pyridone endoperoxidation synthesized in advance The aqueous solution of the product was stirred at 1°C for 1.2h to carry out the activation reaction; then the polyallylamine hydrochloride after dehydrochlorination treatment was added, an...

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Abstract

The invention provides a method for controllably synthesizing a CuS@EPO nano material through electrostatic assembling and relates to the technical field of inorganic functional nano materials. The method comprises the following steps: (1) mixing sodium citrate, copper chloride dehydrate and sodium sulfide nonahydrate and reacting at 89 to 95 DEG C for 20 to 35 min, so as to obtain nano CuS; (2) after mixing 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride and N-hydroxysuccinimide, adding carboxylated pyridone endoperoxide and carrying out activation reaction, adding polyacrylaminehydrochloride, and after uniformly mixing, centrifuging to obtain pyridone endoperoxide modified polyacrylamine hydrochloride; (3) mixing the pyridone endoperoxide modified polyacrylamine hydrochloride and the nano CuS to obtain a pyridone endoperoxide modified CuS@EPO nano material. According to the method provided by the invention, a nano-drug still can be used for carrying out PDT (PhotodynamicTherapy) to treat a tumor part without infrared light triggering a photothermal effect; an enriched photothermal reagent CuS can be used for carrying out PTT (Photothermal Therapy) and accelerating the release of singlet oxygen.

Description

technical field [0001] The invention relates to the technical field of inorganic nano-functional materials, in particular to a method for controllably synthesizing CuS@EPO nano-materials through electrostatic assembly. Background technique [0002] Photodynamic therapy is a non-invasive treatment for various tumor diseases. The treatment process includes a photosensitizer, oxygen, and light to construct a photodynamic therapy process and generate singlet oxygen at the tumor site. Singlet oxygen is considered a cytotoxic substance that can interact with nucleic acids, proteins, and DNA and deprive them of their biological activity in photodynamic therapy for cancer treatment. However, the toxic and side effects are small, and the ones without drug resistance seem to have a bright future, but they have great defects. The efficacy of photodynamic therapy for solid tumors is largely limited by a number of issues. Most photodynamic dyes can only be activated by visible light o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K47/58A61P35/00C01G3/12B82Y30/00
CPCA61K41/0042A61K41/0057A61K47/58A61P35/00B82Y30/00C01G3/12C01P2004/64
Inventor 刘见永王治伟丁豪马金良贾潇
Owner FUZHOU UNIV
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