Anti-haze drug, anti-haze mask of anti-haze drug and application of dihydromyricetin in control of haze and treatment of seasonal influenza

A dihydromyricetin and anti-haze technology, applied in the field of biomedicine, can solve problems such as the absence of dihydromyricetin, and achieve the effects of preventing and reducing damage

Inactive Publication Date: 2019-03-26
李定文
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there is no report on the application of dihydromyricetin in the prevention and treatment of smog and seasonal influenza

Method used

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  • Anti-haze drug, anti-haze mask of anti-haze drug and application of dihydromyricetin in control of haze and treatment of seasonal influenza
  • Anti-haze drug, anti-haze mask of anti-haze drug and application of dihydromyricetin in control of haze and treatment of seasonal influenza
  • Anti-haze drug, anti-haze mask of anti-haze drug and application of dihydromyricetin in control of haze and treatment of seasonal influenza

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1 2

[0055] Example 1 Dihydromyricetin control haze experiment

[0056] The experimental animals were divided into three groups (A: normal group, referring to the normal air used in the test aerosol machine in the experiment; B: polluted group, referring to the experiment, the test aerosol machine used SO 2 500 μg / m 3 ;C: Contaminated treatment group, refers to the experimental aerosol using SO 2 500 μg / m 3 , and then mixed with dihydromyricetin 5mg / L).

[0057] For the first three days, the daily treatment method for each group:

[0058] Group A: 5% CO 2 / 95%O 2 , input continuously for 10 minutes.

[0059] Group B: test aerosol using SO 2 500μg / m 3 (concentration 0.5μg / L), mixed with air-conditioning exhaust gas, air pressure 40psi, 10 minutes continuous input.

[0060] Group C: test aerosol using SO 2 500μg / m 3 (concentration 0.5μg / L) was mixed into the air-conditioning exhaust gas, and then mixed with dihydromyricetin 5mg / L, the pressure was 40psi, and the input was ...

Embodiment 2 2

[0064] Embodiment 2 Dihydromyricetin against human influenza A (H1N1) virus infection

[0065] In this example, human influenza A (H1N1) virus 252 (±34) μg / mL particles were used to determine the antiviral effect of dihydromyricetin. The steps are: H1N1 virus particles are co-cultured with dog kidney cells in a medium containing dihydromyricetin for a total of 2 hours, and then washed 3 times. Filter through a filter and remove unbound compounds with common culture medium. Virus particles were harvested and analyzed using a direct binding assay—the dihydromyricetin-bound and unbound fractions were then compared.

[0066] Experimental results such as image 3 As shown, the 50% inhibitory concentration (IC50) of dihydromyricetin to H1N1 is 2.4 μg / mL (8 μM), while the concentration (IC100) of 100% inhibition of H1N1 virus infection is 8 μg / mL (27 μM). It shows that dihydromyricetin has obvious dose-dependent inhibitory effect on H1N1 virus infection.

[0067] We further analy...

Embodiment 3 2

[0068] Example 3 Dihydromyricetin resists respiratory infection caused by streptococcus

[0069] In this experiment, experimental white mice were used to place 100 μl of streptococcus preparation (culture medium) into the oral cavity through the upper incisors to eliminate the liquid intake of the experimental white mice. Inflammation was assessed on day 1 and day 7 post-infection.

[0070] A: The normal group refers to that in the experiment, after placing 100 μl (microliter) of physiological saline in the oral cavity, the liquid intake of the experimental white mice was removed for 30 minutes. From the first day, give 1cm every day 3 Drug-free agar frozen for 7 days.

[0071] B: Contaminated group means that in the experiment, 100 μl of streptococcus preparation (culture medium) was placed in the oral cavity, and the liquid intake of the experimental white mice was removed for 30 minutes. From the first day, give 1cm every day 3 Drug-free agar frozen for 7 days.

[0072...

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Abstract

The invention provides an anti-haze drug, an anti-haze mask of the anti-haze drug and application of dihydromyricetin in control of haze and treatment of seasonal influenza. A product used for haze resistance is prepared from dihydromyricetin. The anti-haze product is a drug, and the drug is capable of obviously preventing and/or alleviating damage of haze to lung organs. Furthermore, the anti-haze product is an anti-haze mask. By using the anti-haze mask, PM10-2.5 particles and/or harmful gases can be filtered, and the filtering rate reaches 95% or higher. Furthermore, a product for treatinginfluenza is prepared with the dihydromyricetin. Since the effect of the dihydromyricetin for inhibiting a human influenza A virus ultravirus H1N1 exceedds 100 times that of other flavonoids compounds, and meanwhile, the damage of infection to the respiratory system can be obviously prevented and alleviated, the product for treating influenza prepared by using the dihydromyricetin is capable of effectively treating various influenzas, and is used for key treatment of patients suffering from influenza A virus H1N1 and/or streptococcus.

Description

technical field [0001] The invention belongs to the field of biomedicine. Specifically, the invention relates to the application of dihydromyricetin in the prevention and treatment of smog and seasonal influenza. Background technique [0002] Smog is a weather phenomenon that occurs when particles such as PM2.5, dust, aerosols and other particles in the floating atmosphere are relatively stable under certain weather conditions such as humidity and temperature. Seasonal flu is characterized by sudden onset of high fever, cough (usually dry), headache, muscle and joint pain, severe malaise (feeling unwell), sore throat and runny nose. Most people recover within a week, with fever and other symptoms gone, without requiring medical attention. But influenza can cause severe illness or death in high-risk groups. Influenza A virus H1N1, also known as H1N1 virus, is a type of influenza A virus and one of the most commonly infected influenza viruses in humans. Treatment of influen...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/352A61P31/04A61P31/16A61P11/00A41D13/11
CPCA41D13/11A61K31/352A61P11/00A61P31/04A61P31/16
Inventor 李定文
Owner 李定文
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