Application of compound preparation containing angelica keiskei to a medicine for preventing or treating sexual dysfunction

A compound preparation, the technology of tomorrow's grass, applied in the field of medicine, can solve the problems of incompleteness, little discussion, and lack of depth, and achieve the effect of increasing sperm count, increasing the number of riding times, and good effect.

Pending Publication Date: 2019-03-29
深圳市本源生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, at present, there are few and incomplete theoretical discussions on the relationship between spleen deficiency, kidney

Method used

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  • Application of compound preparation containing angelica keiskei to a medicine for preventing or treating sexual dysfunction
  • Application of compound preparation containing angelica keiskei to a medicine for preventing or treating sexual dysfunction
  • Application of compound preparation containing angelica keiskei to a medicine for preventing or treating sexual dysfunction

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Embodiment 1 A method for extracting a compound preparation containing Ashitaba from Ashitaba, Dendrobium candidum and Lycium barbarum, comprising the steps of:

[0044] (1) Preparation of Ashitaba extract

[0045] Take 5kg of dried whole Ashitaba and grind it into 80-mesh powder, put it into an extraction tank, add 25L of 50% (v / v) ethanol aqueous solution to it each time, and reflux extraction at 60°C for 2 times, each time for 2 hours , combined the 2 extracts, concentrated under reduced pressure, and freeze-dried to obtain 800.0 g of Ashitina extract powder. The content of chlorogenic acid in this extract powder was measured to be 3.6wt%, and it was set aside.

[0046] (2) Preparation of Dendrobium candidum extract

[0047] Get 2.5kg of dried stems of Dendrobium officinale and grind them into 80 mesh powders, put them into an extraction tank, add 12.5L of water each time, extract at a constant temperature at 60°C for 2 times, each time for 1.5 hours, combine the 2 ...

Embodiment 2

[0052] Embodiment 2 A method for extracting a compound preparation containing Ashitaba from Ashitaba, Dendrobium candidum and Lycium barbarum, comprising the steps of:

[0053] (1) Preparation of Ashitaba extract

[0054] Take 5kg of dried whole Ashitaba and grind it into 80-mesh powder, put it into an extraction tank, add 50L of 80% (v / v) ethanol aqueous solution to it each time, and reflux extraction at 80°C for 3 times, each time for 1 hour , combined the extracts for 3 times, concentrated under reduced pressure, and freeze-dried to obtain 1000.0g of Ashitina extract powder. The content of chlorogenic acid in this extract powder was measured to be 3.9wt%, and it was set aside.

[0055] (2) Preparation of Dendrobium candidum extract

[0056] Take 2.5kg of dried stems of Dendrobium candidum and crush them into 80 mesh powder, put them into an extraction tank, add 25 L of water each time, extract at a constant temperature at 80°C for 3 times, each time for 1 hour, combine the...

Embodiment 3

[0061] Example 3 Effect of a Compound Preparation Containing Ashitaba on the Sexual Behavior of Castrated Male Mice

[0062] The experimental animals were SPF Kunming male young (8 weeks old) mice, 20 old (60 weeks old) mice each, and 40 Kunming female young (8 weeks old) mice (provided by the Hubei Provincial Center for Disease Control and Prevention). supply). Drink water and eat freely, keep the room temperature at 25±1°C, and the light-dark cycle is 12 hours.

[0063] 1. Modeling and administration of castrated male mice

[0064] The young and old male mice were divided into 5 groups: blank control group, model group, low-dose group of a compound preparation containing Ashitaba, high-dose group of a compound preparation containing Ashitaba, testosterone propionate Group. Except for the daily intramuscular injection of normal saline in the blank control group, the mice in the other groups were intramuscularly injected with 25 mg / kg of prednisolone acetate daily, once per...

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Abstract

The invention belongs to the technical field of medicine, and specifically discloses a preparation method of a compound preparation made of angelica keiskei, dendrobium officinale and Chinese wolfberry fruits, and an application of the preparation to a medicine for preventing or treating sexual dysfunction. The compound preparation is prepared by mixing angelica keiskei extractum, dendrobium officinale extractum and Chinese wolfberry fruit extractum. Experiments show that the preparation can increase the number of bestriding in sexual behavior of castrated male mice, increase the number of sperm in sexual dysfunction, and improve the contents of serum testosterone, lutropin, follicle-stimulating hormone and serotonin in individuals with sexual dysfunction. In addition, after using the compound preparation of the present invention, the tissue structure of mouse testesis is relatively complete and distinct in gradation, and more sperm cells exist. The preparation for improving sexual dysfunction of the invention has clear effective components, determined curative effect, no toxic and side effect, easy-to-implement extraction method and broad application prospect.

Description

technical field [0001] The invention relates to the technical field of medicine, and more specifically relates to a composite preparation prepared from Ashitaba, Dendrobium officinale and Lycium barbarum, a preparation method thereof, and an application in preparation of drugs for preventing or treating sexual dysfunction. Background technique [0002] Unspeakable male sexual dysfunction can affect the normal life of husband and wife to a certain extent, and even endanger family stability in severe cases. It is estimated that at least hundreds of millions of men around the world suffer from different degrees of sexual dysfunction. In Shanghai, China, nearly 2,000 urban men over the age of 40 were investigated, and it was found that the incidence of male sexual dysfunction was as high as 73%. [0003] The function of hypothalamic-pituitary-gonadal axis sex hormones in patients with sexual dysfunction is generally disordered, often manifested as low testosterone levels in the...

Claims

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Application Information

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IPC IPC(8): A61K36/8984A61P15/10
CPCA61K36/232A61K36/815A61K36/8984A61K2236/33A61K2236/331A61K2236/39A61K2236/51A61P15/10A61K2300/00
Inventor 唐和斌唐东杰黄夏伶陈怡君赵一鸣张莉平
Owner 深圳市本源生物科技有限公司
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