Preparation method and application of polystyrene macroreticular resin containing multiple phenolic hydroxyl groups
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A technology containing polyphenolic hydroxyl groups and polystyrene, applied in chemical instruments and methods, alkali metal oxides/hydroxides, inorganic chemistry, etc., can solve the problems of rapid resin decay, difficult regeneration, and low adsorption capacity. The effect of long service life, stable performance and high adsorption capacity
Active Publication Date: 2019-04-09
AMICOGEN CHINA BIOPHARM CO LTD
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Problems solved by technology
[0006] The first technical problem to be solved is: general macroporous adsorption resin is prone to pollution, low adsorption capacity, difficult
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Embodiment 1
[0032] The preparation method of polystyrene-based macroporous adsorption resin containing polyphenolic hydroxyl groups is characterized in that the preparation method is a one-pot preparation method, including: aqueous phase preparation, organic phase preparation, distillation, and water washing;
[0033] Specifically: add 14.5g of gelatin dispersant to 1450g of water, heat up to 40-45°C to dissolve for 30 minutes, cool to room temperature, add 1.4g of sodium hydroxide and 2.44g of boric acid, and measure the pH of the solution to be 10.2. Mix the organic phase containing 20g styrene, 180g divinylbenzene, 180g isobutanol, 150g toluene, and 2g benzoyl peroxide initiator 1 into the water phase, disperse into balls, adjust the speed and uniform particle size, and then heat up Up to the reaction temperature, suspension polymerization was carried out, and the reaction was carried out at 78° C. for 2 hours. React at 85-95°C for 14 hours. After the heat preservation is over, wash wi...
Embodiment 2
[0035] Specifically: Add 18g of gelatin dispersant to 1800g of water, heat up to 40-45°C to dissolve for 30 minutes, cool to room temperature, add 1.4g of sodium hydroxide and 2.44g of boric acid, and measure the pH of the solution to be 10.1. Mix the organic phase containing 10g styrene, 190g divinylbenzene, 200g methyl isobutyl carbinol, 200g toluene, and 3g benzoyl peroxide initiator 1 into the water phase, disperse into balls, and adjust the speed After the particle size is uniform, the temperature is raised to the reaction temperature for suspension polymerization, and the reaction is carried out at 78°C for 2 hours. React at 85-95°C for 14 hours. After the heat preservation is over, wash with 1000g of anhydrous salt water for two to three times each time, and then turn on steam distillation. After all the porogens are evaporated, cool down to 40-45°C, and add over Oxidize 2 g of benzoyl and 200 g of pyrogallol, raise the temperature to 75-80° C., react for 12-16 hours, a...
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Abstract
The invention discloses a preparation method and application of polystyrene macroreticular resin containing multiple phenolic hydroxyl groups, belonging to the technical field of high molecular materials. The preparation method is characterized by being a one-pot preparation method comprising the following steps: organic phase preparation, water phase preparation and suspension polymerization; anda copolymerization bead body is subjected to steam distillation, and after a pore-foaming agent is completely evaporated out, an initiator II and pyrogallol are sequentially added into a reaction kettle. The preparation method has the beneficial effects that the preparation is carried out by virtue of the one-pot method, so that the process time is greatly shortened, the process steps are simplified, and the occupation of a large number of production equipment and sites caused due to frequent material guiding is avoided; and pyrogallol is creatively utilized, and the polystyrene macroreticular resin prepared through the one-pot method by taking polystyrene as a skeleton has a relatively high specific surface and contains multiple phenolic hydroxyl groups, so that a hydrogen bond cluster body can be easily formed by proteins, and the polystyrene macroreticular resin has the excellent properties of strong protein adsorption capacity, high adsorption quantity, good selectivity, easinessin regeneration, long service life, stable performance and the like.
Description
Technical field: [0001] The invention belongs to the technical field of polymer materials, and more specifically relates to a preparation method and application of a polystyrene-based macroporous adsorption resin containing polyphenolic hydroxyl groups. Background technique: [0002] The production of cephalosporins accounts for more than 60% of the world's antibiotic production, while the production of cephalosporin C (CPC) in my country accounts for more than 80% of the world's total production. It is generally produced by microbial fermentation, and the fermentation liquid of cephalosporin C produced by fermentation contains a large amount of impurities such as protein and mycelium. It is mainly derived from the culture medium and produced during the fermentation process. The presence of impurities such as protein in the fermentation broth is unfavorable for the filtration and clarification of the CPC filtrate and the subsequent purification. The pretreatment of the fer...
Claims
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