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Preparing method of multifunctional protection coating of medical instruments and medical consumables

A technology for medical devices and protective coatings, applied in coatings, medical science, catheters, etc., can solve the problems of poor binding force, short action time, and easy fall-off of bactericidal coatings, and achieve excellent biocompatibility and three-dimensional Anti-corrosion performance, long-lasting effect

Inactive Publication Date: 2019-04-16
SHANGHAI PARYLENE BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Antibiotics can easily lead to drug resistance problems. After entering the human body, silver ions will accumulate and will not be excreted, which may lead to heavy metal safety issues
Moreover, the bactericidal coating obtained by soaking method has poor bonding force, is easy to fall off, and has a short action time, generally within 2 weeks.

Method used

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  • Preparing method of multifunctional protection coating of medical instruments and medical consumables
  • Preparing method of multifunctional protection coating of medical instruments and medical consumables
  • Preparing method of multifunctional protection coating of medical instruments and medical consumables

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Coating medical catheters

[0038] 1. First, clean medical catheters made of polyethylene, latex, etc., first clean with ethanol, clean for 1 hour, clean twice, then clean with deionized water, clean for 0.5 hours, clean three times, and then set Dry in an oven at 50℃ for 6-8h.

[0039] 2. Surface activation treatment

[0040] Plasma surface activation is performed on the cleaned medical catheter. The soft plastic material has a plasma power of 100W and the activation time is 1 to 3 minutes. The hard plastic material has a plasma power of 300 to 500W and the activation time is 5 to 10 minutes.

[0041] 3. Surface adhesion treatment

[0042] The silane G-570 is uniformly sprayed on the surface of the medical catheter by spraying, and the concentration of silane G-570 is 3.5%.

[0043] 4. Coating treatment

[0044] The medical catheter processed by the above steps is placed in the vacuum coating chamber for coating treatment, and the quaternary ammonium salt or antimicrobial peptide...

Embodiment 2

[0050] Coating medical stainless steel wire

[0051] 1. First, clean the stainless steel medical wire, first clean with ethanol, clean for 1.5 hours, clean 3 times, then clean with deionized water, clean for 0.5 hours, clean twice, and then place it at 60°C Dry in an oven for 5-8h.

[0052] 2. Surface activation treatment

[0053] Perform plasma surface activation on the cleaned stainless steel wire with a plasma power of 1000W and an activation time of 5-10 minutes.

[0054] 3. Surface adhesion treatment

[0055] The silane G-570 is uniformly sprayed on the surface of the medical wire by spraying, and the concentration of silane G-570 is 8%.

[0056] 4. Coating treatment

[0057] The medical wire processed by the above steps is placed in the vacuum coating chamber for coating treatment, and the quaternary ammonium salt or antimicrobial peptide is placed in the drug feeding groove in the middle of the coating chamber according to a certain concentration. The concentration is 5-10mg / ml o...

Embodiment 3

[0061] Coating medical silicone material

[0062] 1. First, clean the medical silica gel material, first clean with ethanol, clean for 1 hour, clean twice, then clean with deionized water, clean for 0.5 hour, clean three times, then place it in a 60℃ oven to dry 8 ~15h.

[0063] 2. Surface activation treatment

[0064] Plasma surface activation is performed on the cleaned medical silica gel with a plasma power of 100W and an activation time of 0.5 minutes.

[0065] 3. Surface adhesion treatment

[0066] The silane G-570 is uniformly sprayed on the surface of the medical silica gel by spraying, and the concentration of silane G-570 is 0.5%.

[0067] 4. Coating treatment

[0068] The medical silica gel processed by the above steps is placed in the vacuum coating chamber for coating treatment, and the quaternary ammonium salt or antimicrobial peptide is placed in the drug feeding groove in the middle of the coating chamber according to a certain concentration. Choose 6-12 mg / ml or the conc...

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Abstract

The invention discloses a preparing method of multifunctional protection coating of medical instruments and medical consumables. The preparing method comprises the steps that ethyl alcohol and deionized water are adopted to clean the medical instruments or medical consumables in sequence; the medical instruments or medical consumables are subjected to plasma surface activation; silane G-570 is adopted to conduct surface adhesion pretreatment; the medical instruments or medical consumables subjected to surface adhesion pretreatment are placed in a vacuum applying chamber, quaternary ammonium salt or antimicrobial peptide is placed in a medicine inlet groove in the middle of the vacuum applying chamber according to certain concentration at the same time, the medical instruments or medical consumables are subjected to parylene coating treatment, in the coating process, a bactericide evaporates and binds to the parylene coating, and thus the bactericide and the parylene coating are subjected to copolymerization to form a parylene coating structure containing the bactericide. The prepared multifunctional protection coating is suitable for various types of medical instruments, and provides multifunctional surface protection functions such as long-term antibacterial protection, biocompatibility, fouling resistance, corrosion resistance, rust resistance and moisture resistance for theimplanted and non-planted medical instruments and the medical consumables.

Description

Technical field [0001] The invention relates to a manufacturing method of a multifunctional protective coating for medical equipment and medical consumables, and belongs to the technical field of biological medical equipment. Background technique [0002] At present, the commercialized antimicrobial coating technology mostly uses antibiotics and antimicrobial silver ions, and combines the antimicrobial agent on the surface of medical consumables by soaking. Antibiotics can easily lead to drug resistance problems. After entering the human body, silver ions will accumulate and will not be excreted, which may lead to heavy metal safety issues. In addition, the bactericidal coating obtained by the immersion method has poor bonding strength, is easy to fall off, and has a short action time, generally within 2 weeks. Summary of the invention [0003] In order to solve the deficiencies of the prior art, the present invention provides a method for manufacturing multifunctional protective...

Claims

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Application Information

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IPC IPC(8): A61L31/08A61L31/10A61L31/14A61L31/16A61L29/08A61L29/14A61L29/16
CPCA61L29/08A61L29/085A61L29/14A61L29/16A61L31/08A61L31/10A61L31/14A61L31/16A61L2300/208A61L2300/252A61L2300/404A61L2420/02C08L89/00
Inventor 张岳张金刚
Owner SHANGHAI PARYLENE BIOTECH
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