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Method for continuously preparing glycine

A technology of glycine and ammonia source, applied in chemical instruments and methods, preparation of cyanide reaction, preparation of organic compounds, etc., can solve the problems of large volume of reactors, many reactors connected in series, long reaction time, etc., to improve the mass concentration , the effect of reducing the tank reactor and shortening the reaction time

Active Publication Date: 2019-04-26
山西华阳集团新能股份有限公司
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  • Application Information

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Problems solved by technology

[0004] The existing technology for continuous preparation of glycine from hydroxyacetonitrile has a low mass concentration of hydantoin aqueous solution in the synthesis reaction, which leads to many series reaction kettles, large reaction kettle volume, and long reaction time in the subsequent kettle-type continuous production process. defect

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  • Method for continuously preparing glycine

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Embodiment 1

[0047] The preparation of embodiment 1 glycine

[0048] The raw materials are hydroxyacetonitrile, ammonium bicarbonate and water, and the three substances are mixed according to the molar ratio of 1:2:50, and are transported by the metering pump to the tubular reactor at 350L / hour for the synthesis reaction. The temperature of the tubular reactor is 100°C , pressure 7MPa, reaction time 25min; Hydantoin aqueous solution is concentrated through the rectifying tower, and the concentrated solution mass concentration is 50%; After that, the concentrated solution enters the still-type series reactor (2 kettles in total) for hydrolysis reaction, and the temperature of the reaction kettle 1 150°C, pressure 7MPa, reaction time 0.5 hours, reaction kettle 2 temperature 165°C, pressure 7MPa, reaction time 0.5 hours; the resulting glycine aqueous solution was crystallized twice, ethanol analyzed twice, centrifuged and dried in a spray dryer to obtain refined glycine.

[0049] According t...

Embodiment 2

[0050] The preparation of embodiment 2 glycine

[0051] The raw materials are hydroxyacetonitrile, ammonium bicarbonate and water, and the three substances are mixed according to the molar ratio of 1:2:50, and are transported to the tubular reactor by the metering pump at 350L / hour for the synthesis reaction. The temperature of the tubular reactor is 120 ℃, pressure 7MPa, reaction time 30min; the hydantoin aqueous solution is concentrated by a rectification tower, and the mass concentration of the concentrated solution is 55%. Temperature 150°C, pressure 7MPa, reaction time 0.5 hours, reactor 2 temperature 160°C, pressure 7MPa, reaction time 0.5 hours, reactor 3 temperature 170°C, pressure 7MPa, reaction time 0.5 hours; the resulting glycine aqueous solution was crystallized 2 times, alcohol analysis 2 times, centrifugal separation and spray dryer drying to obtain refined glycine.

[0052] According to the result analysis, the content of glycine is 99.6%, and the yield of gly...

Embodiment 3

[0053] The preparation of embodiment 3 glycine

[0054] The raw materials are hydroxyacetonitrile, ammonium bicarbonate and water, and the three substances are mixed according to the molar ratio of 1:2:50, and are transported to the tubular reactor by the metering pump at 350L / hour for the synthesis reaction. The temperature of the tubular reactor is 120 ℃, pressure 7MPa, reaction time 45min; the hydantoin aqueous solution is concentrated by a rectification tower, and the mass concentration of the concentrated solution is 60%; after that, the concentrated solution enters the reactor series reactor (a total of 3 kettles) for hydrolysis reaction, and the reaction kettle 1 Temperature 150°C, pressure 7MPa, reaction time 0.5 hours, reactor 2 temperature 160°C, pressure 7MPa, reaction time 0.5 hours, reactor 3 temperature 170°C, pressure 7MPa, reaction time 0.5 hours; the resulting glycine aqueous solution was crystallized 2 times, alcohol analysis 2 times, centrifugal separation a...

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Abstract

The invention provides a method for continuously preparing glycine. The method comprises the steps that hydroxyacetonitrile is synthesized with an ammonia source and a carbon source in a tubular reactor, and an obtained solution is concentrated to obtain a concentrated solution; then the concentrated solution is fed into kettle type series reactors for a hydrolysis reaction to obtain a glycine-containing solution; and the glycine-containing solution is refined to obtain refined glycine. The method adopts a device composed of the tubular packing reactor and the kettle type series reactors to carry out hydantoin synthesis and the hydrolysis reaction, thereby achieving the purpose of continuous production; and meanwhile, a distillation device is added before the hydrolysis reaction, and the mass concentration of a hydantoin aqueous solution is increased, so that in the same glycine yield, the kettle type series reactors are reduced, the volume of the kettle type reactors is reduced, the reaction time is shortened, and the purpose of the continuous production is well achieved.

Description

technical field [0001] The invention relates to the field of fine chemicals, in particular to a method for continuously preparing glycine. Background technique [0002] Glycine, also known as aminoacetic acid, is the amino acid with the simplest structure. As an important fine chemical intermediate, it is widely used in the fields of pesticide, medicine, food, feed, daily chemical and electroplating. my country is the largest producer and consumer of glycine in the world, and the market size of glycine exceeds 350,000 tons. At present, the industrial production technologies of glycine mainly include the improved Streck method, the direct Hyne method and the ammonolysis method of chloroacetic acid. Due to the monopoly of foreign technology, the backward chloroacetic acid method is still used in the production of glycine in my country. Compared with the improved Streck method and the direct Heine method, this method has disadvantages such as high production cost, poor product...

Claims

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Application Information

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IPC IPC(8): C07C229/08C07C227/24C07C227/42C07D233/74
CPCC07C227/24C07C227/42C07D233/74C07C229/08
Inventor 冯志武袁秋华王向龙龚文照张伟赵广贾晨李鑫李凯孟迎
Owner 山西华阳集团新能股份有限公司
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