Regulation and control method and application of hydroxyapatite nanoparticle aggregate

A hydroxyapatite and nano-hydroxyapatite technology, applied in the field of materials, can solve the problem of long (usually dozens of hours, at least ten hours), and low production efficiency of hydroxyapatite nanoparticle aggregates. and other problems, to achieve the effect of simple and easy control method, shortened control period and high degree of dispersion

Active Publication Date: 2021-11-05
佛山仙湖实验室
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the orderly aggregation and regulation of these HAP nanoparticles starts from the nucleation and crystallization of HAP nanoparticles, so the entire period of regulation and aggregation is relatively long (generally dozens of hours, at least ten hours), Low production efficiency of hydroxyapatite nanoparticle aggregates

Method used

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  • Regulation and control method and application of hydroxyapatite nanoparticle aggregate
  • Regulation and control method and application of hydroxyapatite nanoparticle aggregate
  • Regulation and control method and application of hydroxyapatite nanoparticle aggregate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Preparation of nano-hydroxyapatite: first, prepare 0.0668mol / L calcium chloride aqueous solution and 0.04mol / L diammonium hydrogen phosphate aqueous solution respectively. Then, quickly pour 100 mL of diammonium hydrogen phosphate aqueous solution into 100 mL of calcium chloride aqueous solution under vigorous stirring, and adjust the pH value to 10-11 by adding ammonia water dropwise. After reacting with magnetic stirring at 80° C. for 60 minutes, the mixture was centrifuged and washed three times to remove impurity ions, and a white precipitate was obtained, which was lyophilized for use. The white precipitate is rod-shaped nano-hydroxyapatite particles, and its transmission electron microscope picture is shown in figure 1 ,Depend on figure 1 It can be seen that the diameter of nano-hydroxyapatite particles is 10-15 nm, and the length is 30-60 nm.

Embodiment 2

[0047] A method for regulating hydroxyapatite nanoparticle aggregates, comprising the following steps:

[0048] Dissolve polyacrylic acid (PAA) powder in water, adjust its pH value to 8 with sodium hydroxide, and prepare an acrylic acid solution with a concentration of 0.2 g / L. Weigh 134.0 mg of nano-hydroxyapatite particles (HAP) prepared in Example 1, add them to 20 mL of acrylic acid solution, and use 600W power ultrasonic dispersion for 5 minutes to obtain a suspension (that is, hydroxyapatite nano particle aggregates). The molar ratio of PAA / HAP in the suspension was 0.01665, and the mass concentration of nano-hydroxyapatite particles was 6.7g / L. figure 2 is the transmission electron microscope image of the hydroxyapatite nanoparticle aggregates, such as figure 2 As shown, the nano-hydroxyapatite particles in the suspension are in the form of shuttle-type aggregates, the central diameter of which is 77.8±17.1nm, and the length is 278.6±53.0nm.

Embodiment 3

[0050] A method for regulating hydroxyapatite nanoparticle aggregates, comprising the following steps:

[0051] Dissolve polyacrylic acid (PAA) powder in water, adjust its pH value to 7 with sodium hydroxide, and prepare a PAA solution with a concentration of 0.6 g / L. Weigh 134.0mg of the nano-hydroxyapatite particles (HAP) prepared in Example 1, add it to 20mL of PAA solution, and use 600W power ultrasonic dispersion treatment for 5 minutes to obtain a suspension (that is, the aggregation of hydroxyapatite nanoparticles) body). The molar ratio of PAA / HAP in the suspension was 0.05, and the mass concentration of nano-hydroxyapatite particles was 6.7g / L. image 3 is the transmission electron microscope image of the hydroxyapatite nanoparticle aggregates, such as image 3 As shown, the nano-hydroxyapatite particles in the suspension are in the form of shuttle aggregates, the central diameter of which is 55.2±9.6nm, and the length is 284.5±47.9nm.

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Abstract

The invention belongs to the technical field of materials, and discloses a regulation and control method and application of a hydroxyapatite nanoparticle aggregate. The regulation and control method comprises the following steps of: (a) dissolving polyacrylic acid, and regulating the pH value to be neutral or alkaline to obtain a polyacrylic acid solution; and (b) adding nano-hydroxyapatite into the polyacrylic acid solution in the step (a), and mixing under an ultrasonic condition to obtain the hydroxyapatite nanoparticle aggregate. According to the regulation and control method and application of the hydroxyapatite nanoparticle aggregate disclosed by the invention, by combining the ultrasonic dispersion with the polyacrylic acid, nano-hydroxyapatite is regulated to form a shuttle-shaped hydroxyapatite nano-particle aggregate in water, and the dispersity of theaggregate is high. The regulation and control method is simple and easy to implement and high in production efficiency. According to the hydroxyapatite nano-particle aggregate prepared by the regulation and control method, the compounding uniformity of nano-hydroxyapatite and a high polymer material can be remarkably improved, and a composite material with the nano-hydroxyapatite proportion as high as 75.4% is prepared.

Description

technical field [0001] The invention belongs to the technical field of materials, and in particular relates to a regulation method and application of hydroxyapatite nanoparticle aggregates. Background technique [0002] Hydroxyapatite (Ca 10 (PO 4 ) 6 (OH) 2 , HAP) is the main inorganic component of human hard tissue, accounting for 65% in bone and 96% in tooth enamel. Nano-HAP has a higher surface area and surface roughness, which is conducive to cell adhesion and cell-matrix interaction; the high specific surface area and abundant surface adsorption sites of nano-HAP are conducive to the immobilization of drugs and biomolecules; nano-HAP is beneficial to Densification and enhancement of mechanical properties of HAP ceramics. However, due to the small size and large specific surface area of ​​nano-HAP, the number of surface atoms increases sharply, and the surface energy is too high, which makes it easy for nanoparticles to agglomerate irregularly through van der Waals...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08K9/12C08K3/32C01B25/32D01F1/10D01F6/50D04H1/728D04H1/4309
CPCC08K9/12C08K3/32C01B25/327D01F1/10D01F6/50D04H1/728D04H1/4309C01P2004/04C01P2004/30C08K2201/011C08K2003/325
Inventor 韩颖超孙振浩戴红莲
Owner 佛山仙湖实验室
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