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Matrix resin of active biological substance purification and separation medium

A technology for purification and separation of biological substances, applied in the fields of alkali metal oxides/hydroxides, inorganic chemistry, alkali metal compounds, etc., to achieve high adsorption rate, large specific surface area, and excellent performance

Inactive Publication Date: 2019-04-30
CHINA BLUESTAR CHENGRAND CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The present invention aims to solve the problems of the existing purification and separation media, and provides a matrix resin for the purification and separation media of active biological substances. The purification and separation media prepared from the matrix resin has the specificity and advantages of the two purification and separation media

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] A base resin for an active biological substance purification and separation medium, comprising the following raw materials in parts by weight:

[0055] Oil phase:

[0056] Glycidyl methacrylate 60 parts

[0057] 30 parts of ethylene glycol dimethacrylate

[0058] 3 parts divinylbenzene

[0059] Diethylbenzene 50 parts

[0060] 20 parts of 2-ethylhexanol

[0061] quinol 20 parts

[0062] 3 parts dibenzoyl peroxide

[0063] water box:

[0064] 1500 parts of deionized water

[0065] 10% polyvinyl alcohol water solution 5 parts

[0066] Biochemical grade gelatin 45 parts

[0067] Sodium chloride 75 parts

[0068] 15 parts of 0.1% methylene blue aqueous solution.

Embodiment 2

[0070] A base resin for an active biological substance purification and separation medium, comprising the following raw materials in parts by weight:

[0071] Oil phase:

[0072] Glycidyl methacrylate 70 parts

[0073] 40 parts of ethylene glycol dimethacrylate

[0074] 5 parts divinylbenzene

[0075] Diethylbenzene 60 parts

[0076] 30 parts of 2-ethylhexanol

[0077] quinol 30 parts

[0078] Dibenzoyl peroxide 5 parts

[0079] water box:

[0080] 2500 parts of deionized water

[0081] 10 parts of 10% polyvinyl alcohol in water

[0082] Biochemical grade gelatin 75 parts

[0083] Sodium chloride 125 parts

[0084] 0.1% methylene blue aqueous solution 25 parts.

Embodiment 3

[0086] A base resin for an active biological substance purification and separation medium, comprising the following raw materials in parts by weight:

[0087] Oil phase:

[0088] Glycidyl methacrylate 65 parts

[0089] Ethylene glycol dimethacrylate 35 parts

[0090] 4 parts divinylbenzene

[0091] Diethylbenzene 55 parts

[0092] 25 parts of 2-ethylhexanol

[0093] quinol 25 parts

[0094] 4 parts dibenzoyl peroxide

[0095] water box:

[0096] Deionized water 2000 parts

[0097] 10% polyvinyl alcohol aqueous solution 7.5 parts

[0098] Biochemical grade gelatin 65 parts

[0099] Sodium chloride 100 parts

[0100] 0.1% methylene blue aqueous solution 20 parts.

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PUM

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Abstract

The invention relates to a matrix resin of an active biological substance purification and separation medium, and belongs to the technical field of purification and separation mediums, wherein the matrix resin comprises an oil phase and an aqueous phase, wherein the oil phase comprises glycidyl methacrylate, ethylene dimethacrylate, divinylbenzene, diethylbenzene, 2-ethylhexanol, decyl alcohol anddibenzoyl peroxide, and the aqueous phase comprises deionized water, a 10% polyvinyl alcohol aqueous solution, biochemical-grade gelatin, sodium chloride, and a 0.1% methylene blue aqueous solution.According to the present invention, the prepared molecular separation and purification medium of the bioactive macromolecule integrates the advantages of natural separation mediums and synthetic separation mediums, and is a protein separation and purification medium with characteristics of macroporous structure, high adsorption rate, large specific surface area and large adsorption amount so as toprovide a class of separation medium with excellent performance in the protein separation and purification.

Description

technical field [0001] The invention relates to a matrix resin for purification and separation media, more specifically, the invention relates to a matrix resin for purification and separation media of active biological substances, which belongs to the technical field of purification and separation media. Background technique [0002] With the continuous advancement of bioengineering technology and the rapid increase in the demand for returning to nature, the demand for bioactive products in the fields of health food and biomedicine continues to increase, and the requirements for the separation and purification technology of bioactive products are also getting higher and higher. [0003] And the performance requirements for the separation and purification medium, which is the core component of the separation and purification technology, are becoming more and more stringent. Separation and purification media are generally divided into two categories: one is natural sugar sepa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F291/08C08F220/32C08F222/14C08F212/36B01J20/26B01J20/28
CPCB01J20/046C08F261/04C08F289/00B01J20/261B01J20/28011B01J20/28057B01J20/28085C08F220/325C08F222/102
Inventor 高川赵奕王煦怡刘咏梅
Owner CHINA BLUESTAR CHENGRAND CO LTD