Biological sponge based on acellular dermal matrix and preparation method thereof

A decellularized dermis and decellularized technology, applied in the field of biosponge based on acellular dermal matrix and its preparation, can solve problems affecting clinical use, increasing costs, environmental pollution, etc., to ensure biological safety, enhance machinery, and reduce genotoxic effects
CN109701078AActive Publication Date: 2019-05-03上海仁康科技有限公司
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
上海仁康科技有限公司
Publication Date
2019-05-03

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Abstract

The invention discloses a biological sponge based on acellular dermal matrix and a preparation method thereof. The biological sponge is made of an acellular dermal matrix as a raw material, and Ca2<+>and fa-PEG are used for cross-linking. The biological sponge prepared by the invention has a porous structure, has pores which communicate with one another, and has a three-dimensional structure similar to human skin tissue, can enable body tissue cells to grow rapidly, has good plasticity, and can be prepared into different shapes as needed so as to meet the needs. The biological sponge of the invention is an advanced tissue engineering scaffold material, contains rich growth factors, has good biocompatibility, is more conducive to the growth of Sertoli cells, can not only be used for woundrepair, but also is an excellent tissue engineering skin scaffold material, and can be used for repairing skin defects and preparing tissue engineering skin.
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Description

technical field

[0001] The invention relates to the technical field of biomaterials, in particular to a biosponge based on decellularized dermal matrix and a preparation method thereof. Background technique

[0002] Burns, wounds, diabetes, chronic ulcers, etc. often lead to skin defects. Pain, loss of physical function, and changes in appearance caused by refractory, chronic trauma, and tissue defects seriously affect the patient's freedom of movement and quality of life, and further lead to psychological and social problems. Skin transplantation is the most effective treatment for tissue defects and skin pigmentation diseases, but it is limited by sources in clinical practice, which affects the treatment process. Tissue-engineered skin is the most promising treatment method. The current tissue-engineered skin scaffold materials mainly include chemically synthesized materials such as polylactic acid (PLA), poly-left-lactic acid (PLLA), and the like. The material has stab...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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