Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Calcium phosphate nanoclusters, and preparation method and application thereof

A nano-cluster, calcium phosphate technology, applied in the field of calcium phosphate nano-cluster and its preparation, can solve problems such as treating the symptoms but not the root cause, and cannot fundamentally cure osteoporosis, and achieves easy availability of raw materials, easy repetition and industrial application, Simple to use effects

Active Publication Date: 2019-05-07
ZHEJIANG UNIV
View PDF3 Cites 18 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these drugs often treat the symptoms but not the root cause, and cannot fundamentally cure osteoporosis

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Calcium phosphate nanoclusters, and preparation method and application thereof
  • Calcium phosphate nanoclusters, and preparation method and application thereof
  • Calcium phosphate nanoclusters, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047](1) Prepare respectively 0.1mol / L calcium chloride solution, 0.1mol / L disodium hydrogen phosphate solution, 0.3g / mL polyaspartic acid solution and 0.3g / mL polyacrylic acid solution;

[0048] The relative molecular mass of the polyacrylic acid used is 450 kDa, and the relative molecular mass of the polyaspartic acid is 9-11 kDa.

[0049] (2) Take 2mL of calcium chloride solution and 0.2mL of polyaspartic acid solution and mix them uniformly as solution A.

[0050] (3) Mix 2 mL of disodium hydrogen phosphate solution with 0.4 mL of polyacrylic acid solution to form solution B.

[0051] (4) Solution B was slowly added dropwise to solution A to form a mixed solution, and the pH of the mixed solution was adjusted to neutral with sodium hydroxide solution to obtain calcium phosphate nanoclusters.

[0052] Such as figure 1 As shown in a, the newly synthesized calcium phosphate nanoclusters are transparent gels with fluidity, can be injected with a syringe, and have certain vi...

Embodiment 2

[0070] (1) Prepare respectively 0.05mol / L calcium chloride solution, 0.06mol / L potassium dihydrogen phosphate solution, 0.3g / mL polyaspartic acid solution and 0.3g / mL polyacrylic acid solution;

[0071] The relative molecular mass of the polyacrylic acid used is 50 kDa, and the relative molecular mass of the polyaspartic acid is 9-11 kDa.

[0072] (2) Take 2mL of calcium chloride solution and 0.15mL of polyaspartic acid solution and mix them uniformly as solution A.

[0073] (3) Take 2mL of potassium dihydrogen phosphate solution and 0.3mL of polyacrylic acid solution and mix them evenly, as solution B.

[0074] (4) Solution A was slowly added dropwise to solution B to form a mixed solution, and the pH of the mixed solution was adjusted to neutral with sodium hydroxide solution to obtain calcium phosphate nanoclusters.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Particle sizeaaaaaaaaaa
Relative molecular massaaaaaaaaaa
Relative molecular massaaaaaaaaaa
Login to View More

Abstract

The invention discloses a preparation method of calcium phosphate nanoclusters. The preparation method of the calcium phosphate nanoclusters comprises the following steps: dissolving water-soluble calcium salts and polyaspartic acid in water so as to obtain a solution A, wherein mass ratio of the water-soluble calcium salts to the polyaspartic acid is 1 to (0.1-15); dissolving water-soluble phosphates and polyacrylic acid in water so as to obtain a solution B, wherein mass ratio of the water-soluble phosphates to the polyacrylic acid is 1 to (0.1-15); and then, slowly mixing the solution A with the solution B, and adjusting the pH value to 7-8 so as to obtain the calcium phosphate nanoclusters. The preparation method of the calcium phosphate nanoclusters is simple to operate, easy to obtain raw materials, low in cost and feasible for easy repeating. The invention further provides calcium phosphate nanoclusters prepared by the preparation method; and the calcium phosphate nanoclusters are amorphous gel materials of which the particle size is 1 nanometer. The invention further provides application of the calcium phosphate nanoclusters in preparation of drugs for repairing osteoporosis.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to a calcium phosphate nanocluster and its preparation method and application. Background technique [0002] Bone is a multi-level structure formed by directional crystallization of hydroxyapatite (HAP) inserted into the collagen fibers of the network structure through long-term evolution. In natural bone, HAP will gradually grow along the long axis of collagen to form continuous collagen fiber mineralization. This multi-level structure of bone obtained through multi-level layer-by-layer assembly can have strong hardness. And toughness, and used to support the various biochemical functions of organisms. [0003] There are about 30% organic matter in normal bone and about 70% inorganic matter. These organic-inorganic composite structures provide important physiological functions for bones. When the lack of HAP minerals in the bone will lead to osteoporosis, it will become one o...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K33/42A61K47/32A61K47/64A61K9/06A61P19/10
Inventor 姚沙沙林贤丰刘昭明唐睿康
Owner ZHEJIANG UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com