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Bone-like Havers system bioactive scaffold and its preparation method and application

A bioactive, bone-like technology, used in bone implants, medical science, prostheses, etc., can solve the problems of uneven size of stent holes, inability to prepare bioceramic stents, low mechanical strength, etc., to promote osteogenesis and angiogenesis effect

Active Publication Date: 2021-07-13
中科硅诺(太仓)生物材料科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these methods have many shortcomings
The pore sizes of the scaffolds prepared by the pore-forming agent method are not uniform, and the channels are not connected enough; while the mechanical strength of the scaffolds prepared by the template method and the air bubble method is relatively low, which cannot meet the requirements of bone repair materials, and the scaffolds prepared by 3D printing technology Bioceramic scaffolds have become the first choice for preparing bioceramic scaffolds with complex structures due to their high precision and highly controllable shape and size[2]
However, the current extrusion 3D printing technology is still unable to prepare bioceramic scaffolds with bone-like Havers system structure at one time.

Method used

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  • Bone-like Havers system bioactive scaffold and its preparation method and application
  • Bone-like Havers system bioactive scaffold and its preparation method and application
  • Bone-like Havers system bioactive scaffold and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] Use 3ds Max software to design the bracket model, the design size is 10mm in diameter, 3mm in height cylindrical bone imitation Havers system structure bracket, in which the diameter of Havers tube is divided into three types: 1.6mm, 1.2mm, 0.8mm, and the number of Havers tube is 8 indivual. Output the drawn bracket model as an STL format file and import it into the software that comes with the photocuring printer (purchased from Beijing Shiwei Technology Co., Ltd., model autocera-m) for slicing, generate a TDP format file and import it into the printer.

[0059] Pure feldspar powder (purchased from Kunshan Huaqiao Technology New Material Co., Ltd.) 60g, and 1.5g45S5 bioglass powder (purchased from Kunshan Huaqiao Technology New Material Co., Ltd.), 41g photosensitive resin (epoxy acrylic resin, purchased from Jinhua Wanhao Accessories Co., Ltd.) mixed ball mill to obtain the photosensitive ceramic slurry, and put the prepared slurry in the printer for printing to obtai...

Embodiment 2

[0062] Use 3ds Max software to design the bracket model, the design size is 10mm in diameter, 3mm in height cylindrical bone imitation Havers system structure bracket, in which the diameter of Havers tube is 1.6mm, the number of Havers tubes is divided into 2, 4, 8 three kind. Output the drawn bracket model as an STL format file and import it into the software that comes with the photo-curing printer for slicing processing, generate a TDP format file and import it into the printer.

[0063] 50g of pure feldspar powder, mixed with 1.25g of 45S5 bio-glass powder, and 51.25g of photosensitive resin are ball-milled to obtain a photosensitive ceramic slurry, and the prepared slurry is placed in a printer for printing to obtain a scaffold material.

[0064] The printed scaffold was calcined at 1350°C for 3 hours to obtain a pure feldspar ceramic scaffold.

Embodiment 3

[0066] Use 3ds Max software to design the bracket model, the design size is 10mm in diameter, 3mm in height cylindrical bone imitation Havers system structure bracket, in which the diameter of Havers tube is 1.6mm, the number of Havers tubes is divided into 2, 4, 8 three kind. Output the drawn bracket model as an STL format file and import it into the software that comes with the photo-curing printer for slicing processing, generate a TDP format file and import it into the printer.

[0067] 50g of pure β-TCP powder (purchased from Kunshan Huaqiao Technology New Material Co., Ltd.) was mixed with 50g of photosensitive resin and ball-milled to obtain a photosensitive ceramic slurry, and the prepared slurry was placed in a printer for printing to obtain a scaffold material.

[0068] The printed scaffolds were calcined at 1100 °C for 3 hours to obtain pure β-TCP ceramic scaffolds.

[0069] The obtained scaffolds were characterized and evaluated for bioactivity, osteogenesis and a...

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Abstract

The present invention relates to a biologically active scaffold of bone imitation Haversian system and its preparation method and application. The bioactive scaffold of bonelike Haversian system comprises: a hollow column, a network structure located in the hollow cavity of the hollow column, and a network structure formed in the hollow column. There are more than one tubes in the solid part of the hollow column, and the bioactive scaffold is made of bioactive material.

Description

technical field [0001] The invention relates to a biologically active scaffold of a bone-like Havers system, a preparation method and an application thereof, and belongs to the field of biological materials. Background technique [0002] At present, the repair and regeneration of large bone defects caused by surgical treatment of trauma, inflammation and bone tumors is one of the difficulties in the clinical treatment of bone defects. The bone tissue engineering scaffold combined with bone tissue engineering and biomaterials is a hotspot in the study of bone defect repair. At present, scaffolds for bone tissue engineering are mainly divided into three categories, including metal scaffolds, polymer scaffolds, and bioceramic scaffolds[1]. Among them, bioceramic scaffolds have become the best choice for the study of large segmental bone defect repair due to their excellent compressive strength and biological activity. hot material. There are many techniques for preparing cera...

Claims

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Application Information

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IPC IPC(8): A61F2/28A61L27/56B33Y80/00B33Y10/00
Inventor 吴成铁张猛常江陈蕾
Owner 中科硅诺(太仓)生物材料科技有限公司
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