Method for preparing glycan sulfate without pollution

A technology of polysaccharide sulfate and fucoidan sulfate, which is applied in the field of pollution-free polysaccharide sulfate preparation, can solve the problems of unfavorable industrial production, high price of trimethylammonium sulfur trioxide copolymer, etc. Human body absorption, strong biological activity, low molecular weight effect

Inactive Publication Date: 2019-05-14
张涛
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Foreign reports are to use cesium hydroxide and trimethylammonium sulfur trioxide copolymer to react with fucoidan sulfate under the joint action to prepare oversulfated fucoidan sulfate. The sulfation level of the product prepared by this method is Higher, but trimethylammonium sulfur trioxide copolymer is expensive, which is not conducive to industrial production

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0014] (1) Dissolve 1g of sea cucumber fucoidan sulfate in 50ml of water, and carry out the first ultrasonic treatment at a temperature of 30°C. The process parameters of the first ultrasonic treatment are: ultrasonic sound field intensity is 40W / cm2, and ultrasonic frequency is 20kHz, ultrasonic time 10min;

[0015] (2) Perform microwave treatment on the sea cucumber fucoidan sulfate solution in step (1) at a temperature of 60° C., the process parameters of microwave treatment are: microwave power 400W, microwave time 5min;

[0016] (3) The sea cucumber fucoidan sulfate solution in step (2) is subjected to ultrasonic treatment for the second time at a temperature of 40°C, and the resulting solution is dialyzed through a dialysis bag with a molecular cut-off of 1000kDa, vacuum freeze-dried (at 0.1Mpa 0.87g of low molecular weight sea cucumber fucoidan sulfate was obtained after drying at -45°C for 48h), and the process parameters of the second ultrasonic treatment were: ultras...

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PUM

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Abstract

The invention discloses a method for preparing glycan sulfate without pollution. Sea cucumber codium glycan sulfate is used as a raw material for the glycan sulfate. The method for preparing the high-sulfation sea cucumber codium glycan sulfate with a low molecular weight includes breaking glycosidic bonds by the aid of ultrasonic-microwave joint degradation processes; decomposing the sea cucumbercodium glycan sulfate to obtain sea cucumber codium glycan sulfate with a low molecular weight; carrying out sulfation reaction on selected methyl methanesulfonate and the sea cucumber codium glycansulfate with the low molecular weight to obtain the high-sulfation sea cucumber codium glycan sulfate with the low molecular weight. The method has the advantages that the method is low in reaction cost, high in reaction efficiency, free of pollution or side reaction and little in destruction on product structures, preparation procedures are simple, the reaction is mild and controllable, the glycan sulfate which is a product prepared by the aid of the method has the low molecular weight and is high in sulfate radical content and bioactivity, and oxidation-resistant, blood glucose reducing andblood lipid reducing effects and the like can be realized by the glycan sulfate; the glycan sulfate can be advantageously absorbed by human bodies and can be applied to the corresponding industry of healthcare products, functional food or medical formula food and the like, and accordingly the method has extremely high social and economic significance and application potential.

Description

technical field [0001] The invention relates to the technical field of biological extraction, in particular to a pollution-free preparation method of polysaccharide sulfate. Background technique [0002] Sea cucumber is a traditional medicinal and food tonic in my country. Among the 1,100 species of sea cucumbers in the world, only 20 are edible, and most of them are inedible low-value sea cucumbers. The body wall of sea cucumber is the main edible or medicinal part of sea cucumber. In dried sea cucumber, the protein content is as high as 85-90%, the lipid accounts for about 4%, and the polysaccharide accounts for about 6-10%. In addition, it also contains calcium, iron, zinc, manganese, selenium, molybdenum and other trace elements. The body wall of sea cucumber contains a variety of physiologically active substances, such as collagen, sulfated polysaccharides, saponins, sterols, active lipids, etc. [0003] Sulfated polysaccharide is an important component of sea cucumbe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/00A61P39/06A61P3/10A61P3/06
Inventor 张涛
Owner 张涛
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