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A method for purifying folic acid

A folic acid, acid wet technology, applied in the field of folic acid synthesis, to achieve the effect of improving reaction efficiency

Active Publication Date: 2020-07-21
JIHENG PHARMA HENGSHUI CITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The present invention is mainly aimed at improving the two stages of folic acid crude product synthesis and folic acid purification

Method used

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  • A method for purifying folic acid
  • A method for purifying folic acid
  • A method for purifying folic acid

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] Embodiment 1: folic acid crude product is synthesized

[0057] 1. Raw materials for folic acid synthesis:

[0058] N-p-aminobenzoyl-L glutamic acid (ammonia one), 2,4,5-triamino-6-hydroxypyrimidine sulfate (ammonia two), trichloroacetone, sodium metabisulfite, sodium carbonate.

[0059] 2. The reaction equation of folic acid synthesis:

[0060]

[0061] 3. The structure of the reaction tank for the synthesis of folic acid

[0062] The structural design of the reaction tank for the synthesis of folic acid in this embodiment is as follows: figure 1 with Figure 5 Shown:

[0063] A reaction tank for folic acid synthesis, including container, motor 1 (Y7.5KW-4P), reducer 2 (RF97-85rpm), coupling 3 (GT60 / 65), frame 4 (DJ65), installation Bottom cover 5 (R460-25), mechanical seal 6 (212-80), stirring shaft 7 Upper agitator 11 (ACJ900), middle agitator 8 (ACJ900), lower agitator 9 (HCQ600), frequency converter 10 (Y7.5KW).

[0064] The container is an enamel kettle ...

Embodiment 2

[0140] The purification method of embodiment 2 folic acid

[0141] (1) acid-dissolving: drop into about 800Kg of folic acid crude product prepared in the prepared embodiment 1 in the acid-dissolving tank, then slowly add 30wt% dilute sulfuric acid (unit liter) in the acid-dissolving tank, the amount of adding acid is Ensure that the crude folic acid can be completely dissolved, and start stirring after adding the acid until the crude product is completely dissolved and no lumps appear. Then add about 6200L of drinking water, stir for 10 minutes and then let it stand for 30 minutes, then pour the rested material into the plate and frame filter press, and the filter cake is the acid extract.

[0142] (2) Alkali dissolution: Add 2000L of drinking water to the alkali dissolution reaction tank, start stirring, open the jacket steam valve of the alkali dissolution tank for heating, when the temperature in the tank reaches about 70°C, add about 90Kg of acid extract, and continue heat...

Embodiment 3

[0149] Embodiment 3: the purification method of folic acid

[0150] The folic acid wet product prepared by the method of Example 2 (concrete stenoic acid content: 0.6%) is hot-washed, and the specific steps are as follows:

[0151] After refining and pressing, add 850L of purified water to the refining tank, raise the temperature to 60°C and start refining and stirring, put 250L CP hydrochloric acid into the refining tank, and then pump it into the refining plate frame to wash the folic acid wet fine product for about 15 minutes. Immediately after washing, use 4000 liters of pure water at 70°C in another refining tank to continue washing for 40 minutes, and then obtain the finished product of folic acid.

[0152] The statistical results obtained from multiple batches of production show that the folic acid content in the finished folic acid product is less than 0.2 wt%, and the success rate is about 95%. That is, 100 batches of production can successfully prepare folic acid wi...

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Abstract

The invention discloses a method for purifying folic acid. The method for purifying the folic acid comprises the step of thermal washing. The thermal washing step for processing a folic acid wet competitive product comprises the following steps that firstly, diluted hydrochloric acid with the concentration of 5-10wt% and the temperature of 55-65 DEG C is adopted to wash the folic acid wet competitive product; and then, water of 65-75 DEG C is used for continuous material-washing, and finally, a purified folic acid finished product is obtained. According to the method for purifying the folic acid comprises the step of thermal washing, the disc acid content in the folic acid finished product is reduced below 0.2wt% from about 0.6wt% before, and the success rate is increased to 95% at presentfrom 65% before. In addition, the folic acid content in a folic acid crude product reaches more than 79wt%.

Description

technical field [0001] The invention relates to folic acid synthesis technology, in particular to a method for purifying folic acid. Background technique [0002] Folic acid is a B vitamin widely found in green vegetables and fruits. Folic acid is the donor of carbon units in most organisms, and is an essential substance for the biosynthesis of amino acids, nucleic acids, and pantothenic acid. The lack of folic acid in the human body, especially in pregnant women, will cause a decrease in amino acid synthesis and lead to serious diseases, such as megaloblastic anemia in infants, neural tube defects, and cardiovascular diseases. When animals lack folic acid, loss of appetite, stunted growth, and poor feather development occur. [0003] Plants and microorganisms can synthesize folic acid de novo in vivo, but animals and humans cannot. For humans, plants are the main source of folic acid for humans. Therefore, artificial synthesis of folic acid is very important. [0004] C...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D475/04B01J19/18
Inventor 马胜义蔡颂公魏晶磊张志强徐亚威李成成商文雨肖春芳王云跃焦银蕾
Owner JIHENG PHARMA HENGSHUI CITY
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