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Zinc oxide nanosheet array/three-dimensional foam graphene biosensor working electrode and preparation method and application thereof

A foamed graphene and zinc oxide nanotechnology, which is applied in the field of electrochemical detection, can solve the problems of high detection limit and low detection sensitivity of dopamine, and achieve the effects of rapid transfer and improved electrocatalytic performance.

Active Publication Date: 2019-05-21
HARBIN MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Aiming at the current technical problems of low detection sensitivity and high detection limit for dopamine, the present invention prepares foamed graphene by chemical vapor deposition, and then vertically grows zinc oxide nanosheet arrays on the surface of three-dimensional foamed graphene by hydrothermal reaction, thereby Preparation of a Novel ZnO Nanosheet Array / 3D Graphene Foam Biosensor Working Electrode

Method used

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  • Zinc oxide nanosheet array/three-dimensional foam graphene biosensor working electrode and preparation method and application thereof
  • Zinc oxide nanosheet array/three-dimensional foam graphene biosensor working electrode and preparation method and application thereof
  • Zinc oxide nanosheet array/three-dimensional foam graphene biosensor working electrode and preparation method and application thereof

Examples

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Embodiment 1

[0042] Example 1: Preparation of Zinc Oxide Nanosheet Array / 3D Foamed Graphene Biosensor Working Electrode

[0043] The preparation of zinc oxide nanosheet array / three-dimensional foamed graphene biosensor working electrode is carried out according to the following steps:

[0044] (1) Place nickel foam in the center of a quartz tube furnace, and heat it from room temperature at a rate of 20°C / min to 40°C / min under the protection of argon and hydrogen to a temperature of 1000°C to 1100°C. Keep warm for 30min~60min under the condition of 1000℃~1100℃, feed methane gas into the tube furnace at a rate of 5sccm~10sccm for 5min~20min under the condition of temperature 1000℃~1100℃, and then put the quartz tube furnace Cool to room temperature from 1000°C to 1100°C at a cooling rate of 80°C / min to 100°C / min to obtain nickel foam coated with graphene; the density of nickel foam in step (1) is 420g / m 2 ~440g / m 2 , the thickness is 1.6mm~2.0mm; the flow rate of argon described in step (...

Embodiment 2

[0051] Example 2: Preparation of Zinc Oxide Nanosheet Array / 3D Foamed Graphene Biosensor Working Electrode

[0052] The difference between this embodiment and Example 1 is that in step (1), methane gas is passed into the tube furnace at a rate of 7 sccm to 9 sccm for 10 min to 15 min under the condition that the temperature is 1000 ° C to 1100 ° C, and then the quartz tube is The furnace is cooled from a temperature of 1000°C to 1100°C to room temperature at a cooling rate of 85°C / min to 95°C / min to obtain a nickel foam coated with graphene. Others are the same as in Example 1.

Embodiment 3

[0053] Example 3: Preparation of Zinc Oxide Nanosheet Array / 3D Foamed Graphene Biosensor Working Electrode

[0054] The difference between this example and Example 1 or Example 2 is that in step (2), polymethyl methacrylate is added to ethyl lactate, and heated and stirred at a temperature of 90°C to 110°C for 1h to 1.5h The mixed solution is obtained, and the mixed solution is added dropwise on the surface of the nickel foam wrapped with graphene obtained in step (1) at the usage rate of 130 μL-170 μL per square centimeter. Others are identical with embodiment 1 or embodiment 2.

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Abstract

The invention discloses a zinc oxide nanosheet array / three-dimensional foam graphene biosensor working electrode and a preparation method and application thereof. High-conductivity and defect-free three-dimensional foam graphene is synthesized by chemical vapor deposition, a high-specific surface area zinc oxide nanosheet array grows on the surface of the foam graphene by a hydrothermal method, and a novel zinc oxide nanosheet array / three-dimensional foam graphene biosensor working electrode is synthesized. A biosensor prepared by using the working electrode can play a synergistic role betweenthe high-conductivity graphene and the high-specific surface area zinc oxide nanosheet array, the combination between the zinc oxide nanosheet array and the graphene is improved, the zinc oxide nanosheet array growing on the surface of the graphene can provide countless active points, electrons generated by the reaction are directly transferred to the graphene, quick electron transfer is realized, the dopamine electrochemical detection sensitivity can reach 0.95muA / mumol / L, and the problems of low sensitivity and high detection limit when the existing biosensor detects dopamine can be solved.

Description

technical field [0001] The invention relates to a biosensor working electrode and its preparation method and application, in particular to a zinc oxide nanosheet array / three-dimensional foamed graphene biosensor working electrode, its preparation method and its application in detecting dopamine. The invention belongs to the technical field of electrochemical detection. Background technique [0002] The chemical name of dopamine (Dopamine, DA) is 3,4-dihydroxy-β-phenylethylamine, which is a key neurotransmitter distributed in the hypothalamus and pituitary gland to transmit biological impulses. The content of dopamine in the human body is low. Once the concentration of dopamine is abnormal, it may lead to neurological diseases, such as Alzheimer's disease and Parkinson's disease. Therefore, it is of great significance to accurately measure the concentration of dopamine in the human body. At present, there are still many problems in the detection of dopamine, such as low sen...

Claims

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Application Information

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IPC IPC(8): G01N27/327G01N27/48C01B32/184C01G9/02C23C28/04B82Y15/00B82Y30/00
Inventor 黄硕宋姗姗岳红彦高鑫
Owner HARBIN MEDICAL UNIVERSITY