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Composite solution of telamycin and gamithromycin and its preparation method and application

A technology of teramycin and gamithromycin, which is applied to medical preparations with non-active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas to achieve improved solubility, good stability, and good therapeutic effects

Active Publication Date: 2021-07-02
AMICOGEN CHINA BIOPHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The etiology is pathogenic microorganism infection, which is mainly seen in some special infectious diseases, such as pneumonia caused by bovine pneumonia, goat, and equine infectious pleuropneumonia, often accompanied by lobar pneumonia, but there is no evidence yet Show that gamithromycin and other antibiotics have a significant therapeutic effect on this type of bacterial lobar pneumonia

Method used

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  • Composite solution of telamycin and gamithromycin and its preparation method and application
  • Composite solution of telamycin and gamithromycin and its preparation method and application
  • Composite solution of telamycin and gamithromycin and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] 1L compound solution of Tyramycin and Gamithromycin, containing:

[0017] Tyramycin: 30g

[0018] Gamimycin: 150g

[0019] 10% citric acid aqueous solution: 100ml

[0020] Thioglycerol: 50g

[0021] Phenol: 20g

[0022] Propylene glycol: 600ml

[0023] The balance is pure water.

[0024] The preparation method is as follows: mix the above-mentioned pH regulator with some solvents, add Tyramycin and Gamithromycin respectively, heat at 30°C to dissolve completely, then add antibacterial agents, and finally add the remaining solvent, filter to obtain Tyramycin A compound solution of ramromycin and gamithromycin.

Embodiment 2

[0026] 1L compound solution of Tyramycin and Gamithromycin, containing:

[0027] Tyramycin: 10g

[0028] Gamimycin: 20g

[0029] 30% sodium dihydrogen phosphate aqueous solution: 20ml

[0030] Thioglycerol: 10g

[0031] Benzyl alcohol: 50g

[0032] Polyethylene glycol: 200ml

[0033] The balance is pure water.

[0034] The preparation method is as follows: mix the above-mentioned pH regulator with some solvents, add Tyramycin and Gamithromycin respectively, heat at 50°C to dissolve completely, then add antibacterial agents, and finally add the remaining amount of solvent, filter to obtain Tyramycin A compound solution of ramromycin and gamithromycin.

Embodiment 3

[0036] 1L compound solution of Tyramycin and Gamithromycin, containing:

[0037] Tyramycin: 20g

[0038] Gamimycin: 60g

[0039] 20% succinic acid aqueous solution: 60ml

[0040] Thioglycerol: 30g

[0041] Benzoic acid: 30g

[0042] Formaldehyde glycerol: 400ml

[0043] The balance is pure water.

[0044] The preparation method is as follows: mix the above-mentioned pH regulator with some solvents, add Tyramycin and Gamithromycin respectively, heat at 70°C to dissolve completely, then add antibacterial agents, and finally add the remaining amount of solvent, filter to obtain Tyramycin A compound solution of ramromycin and gamithromycin.

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Abstract

The invention provides a composite solution of Tyramycin and Gamithromycin and a preparation method thereof, which belongs to the field of veterinary antibiotics, and is characterized in that it consists of two parts: a main drug and an auxiliary material, and the main drug is Tyramycin Mycin and Gamithromycin are two components, and the adjuvant includes a pH regulator, an antioxidant, a bacteriostatic agent, a solvent, and the composite solution has a good therapeutic application in the treatment of bacterial lobar pneumonia; It has the advantages of low cost, remarkable curative effect and low pollution coefficient, which is convenient for farmers to use and has high economic utility.

Description

technical field [0001] The invention relates to the field of veterinary antibiotics, in particular to a composite solution of teramycin and gamithromycin and a preparation method and application thereof. Background technique [0002] With the rapid development of global economic integration, my country's aquaculture industry is also showing a situation of scale, intensification and standardization. With the continuous expansion of the production scale of animal husbandry and the continuous increase of breeding density, the chances of pathogen infection of livestock and poultry increase, the probability of pathogen mutation increases, and the risk of new epidemic diseases increases. The requirements for the production safety of the breeding industry, the quality and safety of animal products and the safety of public health are constantly increasing. Animal respiratory diseases are easy to occur and difficult to treat. In addition, blind drug use and excessive drug use will l...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7052A61K9/08A61K47/10A61P11/00A61P31/04
Inventor 李婷李建国王玲张蓓蓓
Owner AMICOGEN CHINA BIOPHARM CO LTD