Multi-channel high-flux composite ionization device

A high-throughput, multi-channel technology, applied in the field of ionization, can solve the problems of less channels, low ionization efficiency, and low flux, and achieve the effect of increasing coverage

Active Publication Date: 2019-06-07
SUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] The disadvantages of the traditional single ion source are relative

Method used

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  • Multi-channel high-flux composite ionization device
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  • Multi-channel high-flux composite ionization device

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] The structure of compound ionization source with four-channel sampling is as follows: figure 1 As shown, on the upper, lower, front and rear surfaces of the front-stage large cylindrical quartz glass tube 1, sampling slots 2 are vertically provided respectively. The outer sides of the four sampling slots are respectively connected to a DC high-voltage power supply 10. Before sample injection, the air inlet channel 4 is first opened to feed helium, and a high-voltage high-frequency power supply 8 is connected between the metal needle electrode 7 and the copper sheet ring electrode 6 to ensure A plasma flame 12 is pre-generated in the secondary ionization part of the latter stage. During sample injection, the four-way injector 9 injects the sample into the corresponding sample injection tank at a certain flow rate, and manually injects the sample. Under the action of DC high voltage, the sample solution is atomized into charged droplets 3 at the tip of the spray needle 5...

Embodiment 2

[0050] The structure of the four-channel injection ionization source combined with four liquid chromatography LCs is as follows: image 3 As shown, in this example, the four-way sampling grooves on the surface of the quartz glass tube are respectively connected to four liquid chromatographs through hollow capillaries, and the automatic sampling is directly through the liquid chromatograph, and the four-way LC combination can realize time-sharing multiplexing. use. When one liquid chromatograph finishes working and needs to deal with waste liquid and clean it, the other three liquid chromatographs can replace it and continue to inject samples. Figure 4Shown is the sequence diagram of four liquid chromatographs automatically injecting samples sequentially. Similarly, before sample injection, the inlet channel 4 is opened first, and the high-voltage and high-frequency power supply 7 is connected between the two electrodes to ensure that the plasma flame 10 is generated in advan...

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Abstract

The invention discloses a multi-channel high-flux composite ionization device comprising a quartz glass tube, a sampling slot, a charged liquid droplet, an air inlet channel, a spray needle, a copperring electrode, a metal needle electrode, a high-voltage high-frequency power source, an injector, a DC high-voltage power supply and a mass spectrometry interface. The multi-channel high-flux composite ionization device has the following beneficial effects: multi-channel high-flux mass spectrometry feeding is realized, the coverage range is large, and the efficiency and speed of liquid chromatography-mass spectrometry analysis are improved; the atomized charged droplet formed by the sample that is not ionized fully in the first-stage ionization process can be in full contact with a plasma flame in second-stage ionization in the composite ionization source, so that the full ionization is realized and the efficiency is improved to a certain extent; the device can be used by combining the liquid chromatography (LC); and time-division multiplexing and automatic feeding are realized, so that the utilization rate of the ionization source is increased.

Description

technical field [0001] The invention relates to the technical field of ionization, in particular to a multi-channel, high-throughput composite ionization device. Background technique [0002] As a leader among modern analytical instruments, the development of commercial and miniaturized mass spectrometers is very rapid in recent years. In the mass spectrometry technique, the ionization of the sample is a prerequisite step, and the ionization efficiency directly affects the analytical performance of the entire instrument. It can be seen that the research on the ion source is crucial. Therefore, research on ionization sources with high efficiency, wide application range, good real-time performance, multi-channel, and high throughput has always been a hot spot in the field of mass spectrometry. Therefore, various new ion source structures and ionization techniques emerge in an endless stream. For example, in 2007, Professor Zhang Xinrong of Tsinghua University proposed for th...

Claims

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Application Information

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IPC IPC(8): G01N27/68
Inventor 李晓旭葛赛金张英军朱雯飞吴辉钱洁
Owner SUZHOU UNIV
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