Nano microspheres with NADH (nicotinamide adenine dinucleotide) or NADPH (nicotinamide adenine dinucleotide phosphate) and preparation method and application thereof
A technology of nano-microspheres and pharmaceutical preparations, which is applied in the field of nano-microspheres containing NADH or NADPH and their preparation, which can solve the problems of unstable chemical properties, loss of activity, and inability to take orally, so as to prolong the storage time, solve the problems of easy decomposition, The effect of reducing the difficulty of saving
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Embodiment 1
[0047] Preparation of NADH-containing nanospheres:
[0048] (1) In parts by weight, weigh 30 parts of gelatin, add 50 parts of distilled water to the gelatin to swell for 10 hours to make a sol, heat the sol at 40° C. for 35 minutes, and filter to obtain a gelatin solution.
[0049] (2) In parts by weight, 20 parts of NADH are added to the gelatin solution, stirred at a speed of 1000r / min for 20min, and 15 parts of binder and 15 parts of stabilizer are added during stirring, so The binder is xanthan gum, the stabilizer is vitamin E, and a mixed solution is obtained.
[0050] (3) Place the mixed solution in an ice-water bath to cool down to 0-10° C., add sodium hydroxide to adjust the pH of the mixed solution to 6-8, solidify, and vacuum-dry to obtain NADH-containing nanospheres.
Embodiment 2
[0052] Preparation of NADPH-containing nanospheres:
[0053] (1) In parts by weight, weigh 40 parts of gum arabic, add 50 parts of distilled water to the gum arabic to make it swell for 10-20 hours to make a sol, heat the sol at 50°C for 25 minutes, and filter to obtain acacia glue solution.
[0054] (2) In parts by weight, 20 parts of NADPH are added to the gum arabic solution, stirred at a speed of 1500r / min for 20min, and 10 parts of binder and 15 parts of stabilizer are added during stirring, The binder is guar gum, and the stabilizer is chlorophyll to obtain a mixed solution.
[0055] (3), place the mixed solution in an ice-water bath to cool down to 0-10° C., drop a calcium chloride solution with a concentration of 1% to 10% into the mixed solution to solidify, and wash with a sodium chloride solution , and vacuum-dried to obtain NADPH-containing nano-microspheres, which are sized through a 20-mesh or 25-mesh sieve.
Embodiment 3
[0057] Preparation of NADH-containing nanospheres:
[0058] (1) In parts by weight, weigh 50 parts of chitosan, add 100 parts of distilled water to chitosan to make it swell for 10-20 hours to make a sol, heat the sol at 60°C for 15 minutes, filter A chitosan solution was obtained.
[0059] (2) In parts by weight, 20 parts of NADH are added to the chitosan solution, stirred at a speed of 1200r / min for 20min, and 5 parts of binder and 15 parts of stabilizer are added during stirring , the binder is guar gum, and the stabilizer is chlorophyll to obtain a mixed solution.
[0060] (3), place the mixed solution in an ice-water bath to cool down to 0-10°C, solidify, and vacuum-dry to obtain NADH-containing nanospheres, and add a concentration of 70% NADH-containing nanospheres to the NADH-containing nanospheres Ethanol, place the weighed NADH-containing nano-microspheres on a set of sieves whose sieve size decreases from the inside to the outside, and the NADH-containing nano-micr...
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