Application of scutellarin to preparing kidney ischemic reperfusion injury preventing/protecting drugs/drug combinations

A technology of ischemia-reperfusion and baicalin, applied in the field of biomedicine, can solve the problem of lack of strong evidence of drug action
CN109908166AInactive Publication Date: 2019-06-21THE AFFILIATED HOSPITAL OF QINGDAO UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
THE AFFILIATED HOSPITAL OF QINGDAO UNIV
Publication Date
2019-06-21
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses application of scutellarin to preparing kidney ischemic reperfusion injury preventing / protecting drugs / drug combinations and belongs to the field of biological medicines. The application proves possibility of the preventing / protecting effects of the scutellarin on human ischemic reperfusion-induced acute kidney injury; data show that the content of Nrf2 (nuclear factor erythroid-2-related factor 2) proteins in a kidney ischemic reperfusion model is significantly reduced, and after the scutellarin is applied, expression of Nrf2 genes can have change of statistical significance, and by means of the molecule docking technology, possibility of interaction of scutellarin molecules and the protein structure is testified, and a theoretical foundation for enlarging the possible application range of the scutellarin can be provided. The application of the scutellarin to preparing kidney ischemia reperfusion injury preventing / protecting drugs / drug combinations can be applied to theoretical research and clinical treatment of kidney ischemic reperfusion injury and provide the theoretical foundation for enlarging the possible application range.
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Description

technical field

[0001] The invention belongs to the field of biomedicine, and in particular relates to the application of scutellarin in the preparation of a drug / medicine composition for preventing / protecting renal ischemia-reperfusion injury. Background technique

[0002] Acute kidney injury (Acute Kidney Injury, AKI) is caused by a variety of etiologies and causes a sudden decline in renal function within a short period of time, with a mortality rate as high as 50%-79%. Renal ischemic injury is one of the most common causes of AKI, and it is widely seen clinically in pathological conditions such as surgery, kidney transplantation, and acute cardiac insufficiency. A large number of animal model experiments and human histopathological studies of renal ischemia-reperfusion injury have shown that oxidative stress, inflammation and apoptosis may be the most important pathophysiological changes of ischemic acute kidney injury.

[0003] Scutellarin (CAS: 27740-01-8) is a Chines...

Claims

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