Traditional Chinese medicine composition for relaxing bowels, preparation method and application thereof

A technology of laxative and composition, applied in the directions of drug combination, pharmaceutical formula, medical preparation containing active ingredients, etc., can solve the problems of affecting physical health, increasing side effects, many drug components, etc., and achieves good bowel moistening. Laxative effect, simple composition, effect of reducing the risk of side effects

Pending Publication Date: 2019-06-28
TSING HUA DE REN XIAN HAPPINESS PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The lifestyle of modern people has undergone great changes compared with the past. Many people are sedentary, they are not tired of eating fine food, and their fiber intake is getting less and less. Some people drink too much alcohol, and various reasons lead to digestive disorders Constipation of the large intestine is the most common phenomenon, which brings unspeakable suffering to many people and affects the health of the body
[0004] At present, there are many traditional Chinese medicine compositions for laxatives and laxatives on the market, but usually there are many and complex ingredients in the medicine.

Method used

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  • Traditional Chinese medicine composition for relaxing bowels, preparation method and application thereof
  • Traditional Chinese medicine composition for relaxing bowels, preparation method and application thereof
  • Traditional Chinese medicine composition for relaxing bowels, preparation method and application thereof

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Experimental program
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Effect test

preparation example Construction

[0029]According to a typical embodiment of the present invention, a preparation method of the above-mentioned traditional Chinese medicine composition is provided. The preparation method includes the following steps: S1, taking aloe vera and angelica with a mass ratio of 2-5:1.5-12 and placing them in an extraction tank for leaching with water, the steam pressure of the leaching is 0.25-0.35MPa, and the temperature is 70-90 ℃, after the leaching is completed, an extract is obtained; S2, the extract is concentrated under reduced pressure, the vacuum degree of the vacuum concentration is -0.08~-0.06MPa, the vapor pressure is 0.25~0.35MPa, and the temperature is 60~70℃ , obtain clearing paste; and S3, use clearing paste as an active ingredient to prepare a traditional Chinese medicine composition for moistening intestines and laxatives; preferably, the extraction is carried out in two or more times; more preferably, the extraction includes: adding 6 to 10 times the amount of wate...

Embodiment 1

[0034] 1. The effect of traditional Chinese medicine composition on small intestinal peristalsis in mice

[0035] 1. Principle: The modeling drug compound diphenoxylate was given by oral gavage to establish a mouse small intestinal motility inhibition model, and the ink propulsion rate of the small intestine within a certain period of time was calculated to judge the gastrointestinal motility function of the model mice.

[0036] 2. Samples and Instruments

[0037] 2.1 Samples and Instruments

[0038] 2.1.1 1# sample: provided by Tsinghua Deren Xi'an Xingfu Pharmaceutical Co., Ltd. (Aloe vera-Angelica sinensis is fed at a ratio of 5:9, decocted and extracted with appropriate amount of water, and concentrated to 500ml, which is called the original solution), each 1ml is equivalent to the total crude drug Quantity 0.4844g.

[0039] The above-mentioned stock solution preparation method is as follows:

[0040] Take aloe vera and angelica and place them in a multi-functional extr...

Embodiment 2

[0120] Effects of different proportions of traditional Chinese medicine compositions on laxative effect

[0121] 1. Principle: The beneficial effect of the ratio of the traditional Chinese medicine composition (aloe and angelica) of the present invention is proved by the results of the mouse gastrointestinal motility experiment and the mouse defecation experiment.

[0122] 1.1 Gastrointestinal peristalsis experiment in mice: The model drug compound diphenoxylate was administered orally by gavage to establish a mouse model of intestinal peristalsis inhibition, and the ink propulsion rate of the small intestine within a certain period of time was calculated to determine the gastrointestinal peristalsis function of the model mice.

[0123] 1.2 Defecation experiment in mice: The model drug compound diphenoxylate was given by oral gavage to establish a mouse model of constipation, and the time of the first melena excretion, the number of melena grains within 6 hours and the melena e...

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Abstract

The invention discloses a traditional Chinese medicine composition for relaxing bowels and a preparation method and application thereof. The active ingredients of the traditional Chinese medicine composition are prepared from the extracts of medicinal raw materials, and the medicinal raw materials include aloe and angelica sinensis with the mass ratio of (2-5) to (1.5-12). By applying the technical scheme of the invention, the traditional Chinese medicine composition for relaxing bowels is simple in composition, the effective ingredients are extracted from the aloe and angelica sinensis, possibly existing excessive reactions of complicated ingredients are avoided, the risk of side effects generated after medicine taking is obviously reduced, and the traditional Chinese medicine compositionhas a good bowel relaxing effect.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine, in particular, to a traditional Chinese medicine composition for moistening the bowels and laxative, a preparation method and application thereof. Background technique [0002] Constipation is a common clinical symptom, mainly refers to the decrease in the frequency of defecation, the decrease in the amount of feces, the dryness of the feces, and the laborious defecation. When two or more of the above symptoms are present at the same time, symptomatic constipation can be diagnosed. Usually, the frequency of defecation is reduced. Generally, defecation once every 2 to 3 days or more (or less than 3 times a week) is constipation. [0003] The lifestyle of modern people has undergone great changes compared to before. Many people are sedentary for a long time, they are not tired of eating fines in diet tests, and they consume less and less fiber. Some people drink excessively, a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/896A61K36/886A61P1/10
CPCA61K36/886A61K36/896A61P1/10
Inventor 杜成强
Owner TSING HUA DE REN XIAN HAPPINESS PHARMA
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