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Ligusticum wallichii whitening W/O/W type compound emulsion and preparation method and application thereof

A whitening and chuanxiong technology, applied in the field of pharmacy, can solve the problems of difficult skin absorption, underutilization of phenolic acids, poor stability, etc., and achieves the effects of stable physical and chemical properties, scientific design, and easy skin absorption.

Active Publication Date: 2019-07-12
SOUTHWEST UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The invention provides a whitening W / O / W complex emulsion of Rhizoma Chuanxiong, which solves the problems in the prior art that the phenolic acids of Rhizoma Chuanxiong are not fully utilized, have poor stability and are not easily absorbed by the skin

Method used

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  • Ligusticum wallichii whitening W/O/W type compound emulsion and preparation method and application thereof
  • Ligusticum wallichii whitening W/O/W type compound emulsion and preparation method and application thereof
  • Ligusticum wallichii whitening W/O/W type compound emulsion and preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0035] The present embodiment provides the determination method of chlorogenic acid, caffeic acid and ferulic acid in Chuanxiong Rhizoma W / O / W type double emulsion of the present invention, specifically:

[0036] Chromatographic conditions and system suitability test: Octadecylsilane bonded silica gel is used as filler; acetonitrile is used as mobile phase A, 0.1% phosphoric acid solution is used as mobile phase B, and gradient elution is carried out according to the regulations in the table below; The detection wavelength is 324nm.

[0037] Table 1

[0038] time (minutes) Mobile phase A(%) Mobile phase B(%) 0～5 5→16 95→84 5～15 16 84 15～20 16→30 84→70 20～25 30 70

[0039] Preparation of reference solution: Take appropriate amount of reference substances of chlorogenic acid, caffeic acid and ferulic acid respectively, weigh them accurately, add 70% ethanol to make each 1 mL contains 0.236 mg of chlorogenic acid, 0.210 mg of caffeic aci...

Embodiment 2

[0043] The present embodiment provides the calculation method of the embedding rate of Rhizoma Chuanxiong W / O / W type double emulsion of the present invention, specifically:

[0044] Embedding rate = W 包埋 / W 总 ×100%,

[0045] W 总 The total amount of chlorogenic acid, caffeic acid and ferulic acid in the Chuanxiong phenolic acid extract added for the preparation of double milk, W 包埋 It is the total amount of chlorogenic acid, caffeic acid and ferulic acid in double milk.

[0046]The method for measuring the content of chlorogenic acid, caffeic acid and ferulic acid in the double milk is determined according to the method of Example 1.

[0047] Compared with Example 1, the content determination method of chlorogenic acid, caffeic acid and ferulic acid in Chuanxiong phenolic acid extract is different only in the preparation of the test solution, and the rest of the conditions are the same. The preparation method of the test solution is: take an appropriate amount of chuanxion...

Embodiment 3

[0049] The present embodiment provides the Chuanxiong W / O / W type double emulsion centrifugal retention rate determination method of the present invention, specifically:

[0050] Take 5 mL of freshly prepared Chuanxiong W / O / W double emulsion in a graduated centrifuge tube, centrifuge at 8000r / min for 15min, separate the double emulsion, and read the total volume of the double emulsion in the centrifuge tube (V 复 ) and the volume of the lower external aqueous phase (V 水 ), calculate the centrifugation retention rate of the Chuanxiong W / O / W type double emulsion milk layer by the formula, the centrifugal retention rate of the double emulsion=(V 复 -V 水 ) / V 复 ×100%.

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Abstract

The invention discloses a ligusticum wallichii whitening W / O / W type compound emulsion and a preparation method and application thereof. The problems that phenolic acid substances of ligusticum wallichii in the prior art are not fully utilized, poor in stability and not easy to absorb by skin are solved. According to the ligusticum wallichii whitening W / O / W type compound emulsion, an inner aqueousphase of the compound emulsion is an aqueous solution containing a ligusticum wallichii phenolic acid extract, an oil phase is mixed oil containing ligusticum wallichii volatile oil, and an external phase is water. The preparation method comprises the steps that the inner aqueous phase, the oil phase and a first emulsifier are mixed and emulsified to prepare a primary emulsion; the prepared primary emulsion, an outer aqueous phase and a second emulsifier are mixed and emulsified to prepare the compound emulsion. The invention discloses application of the ligusticum wallichii whitening W / O / W type compound emulsion in preparing medicines and cosmetics with a whitening function. The compound emulsion is scientific in design and simple and convenient to operate, so that ligusticum wallichii resources are fully utilized, the stability of the phenolic acid substances of ligusticum wallichii is effectively improved, and the phenolic acid substances are easy to absorb by the skin.

Description

technical field [0001] The invention belongs to the technical field of pharmacy, and in particular relates to a Chuanxiong whitening W / O / W complex emulsion and a preparation method and application thereof. Background technique [0002] Ligusticum chuanxiong is the dried rhizome of Ligusticum chuanxiong Hort., an umbrella plant. It has the effects of promoting blood circulation, dispelling wind and relieving pain. As an authentic traditional Chinese medicine in Sichuan, the annual output of Chuanxiong is more than 75% of the national output. Currently, Chuanxiong is generally used as decoction pieces, but the actual usage and consumption rate is about 7%. When used as a raw material for preparations, only a certain amount is often used Some parts, such as Suxiao Jiuxin pills, use alkaloid parts, while volatile oil, phenolic acid, polysaccharides and other parts are wasted; Chuanxiong oil soft capsules, butylphthalide soft capsules and butylphthalide injections developed by ph...

Claims

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Application Information

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IPC IPC(8): A61K8/9789A61K8/92A61K8/06A61Q19/02A61K36/236A61K9/113A61K47/44A61P17/00
CPCA61K8/066A61K8/922A61K9/113A61K36/236A61K47/44A61Q19/02A61K8/9789A61P17/00
Inventor 杨荣平张琳
Owner SOUTHWEST UNIVERSITY