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Method for preparing polyester organic high-molecular microspheres through film emulsification approach

A technology of organic polymer and membrane emulsification method is applied in the field of preparing polyester organic polymer microspheres by membrane emulsification method to achieve the effects of improving urinary incontinence, shortening preparation time and improving gastric reflux.

Active Publication Date: 2019-07-12
山东采采医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The emulsified microspheres will not stick together when the stirring is turned on, which perfectly solves this problem

Method used

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  • Method for preparing polyester organic high-molecular microspheres through film emulsification approach
  • Method for preparing polyester organic high-molecular microspheres through film emulsification approach
  • Method for preparing polyester organic high-molecular microspheres through film emulsification approach

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Weigh 77.4g of PCL with a Mn of 93200 and dissolve it in dichloromethane (solution viscosity is 1200cp), and disperse the oil phase solution into a high-speed shear solution containing (0.1%) sodium chloride, (0.5% ) polypropylene alcohol, (1%) carrageenan aqueous solution and (0.2%) Tween 80 mixed solution, the obtained microspheres were filtered, washed and dried. Microsphere average diameter is about 35um, Span1.25, yield is about 80%, the microsphere photomicrograph prepared in embodiment 1 is as follows figure 1 shown.

Embodiment 2

[0044] Weigh 88.7g of PCL with a Mn of 56000 and dissolve it in acetone (solution viscosity is 1100cp), and disperse the oil phase solution into a high-speed shearing solution containing (0.2%) polyvinyl alcohol, (0.2%) fatty acid Sorbitan (Span), and (0.5%) sodium alginate aqueous solution, the resulting microspheres were filtered, washed, and dried. Microsphere mean diameter about 45um, Span1.21, yield is about 72%, the microsphere photomicrograph that embodiment 2 prepares is as follows figure 2 shown.

Embodiment 3

[0046] Weigh 53.9g of PCL with a Mn of 40,000 and dissolve it in dichloromethane (viscosity 800cp), and disperse the oil phase solution into a high-speed shear solution containing (1%) polyvinyl alcohol, (0.1%) spit Warm 80 solution and (2.2%) sodium carboxymethylcellulose aqueous solution, the resulting microspheres were filtered, washed and dried. Microsphere mean diameter about 50um, Span1.19, yield is about 75%, the microsphere photomicrograph prepared by embodiment 3 is as follows image 3 shown.

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Abstract

The invention provides a method for preparing polyester organic high-molecular microspheres through a film emulsification approach and relates to the field of medical apparatuses and instruments and medicine preparation. Compared with the prior art, the microspheres prepared through the method have the advantages of being narrower in particle size distribution, simpler and more direct in preparation method and higher in yield. According to the method, a polyester organic high-molecular material is dissolved in an organic solvent to form an oil phase, a certain quantity of one or more of a penetration promoting agent, a surfactant, a film forming agent and a thickening agent are dissolved in water to form an aqueous phase, and pressure is applied to extrude an oil-phase solution from one surface of a film tube to another surface in contact with the aqueous phase by utilizing the characteristic that the polyester organic high-molecular material is insoluble in water, wherein extruded oil-phase drops are solidified in the aqueous phase and subjected to solid-liquid separation and drying to obtain the microspheres with the particle size meeting the clinical requirements. The polyesterorganic high-molecular polymer microspheres prepared by means of the method can be used in the industries such as beauty treatment and medical treatment.

Description

technical field [0001] The invention relates to the field of medicine preparation, in particular to a method for preparing polyester organic polymer microspheres by using a membrane emulsification method. Background technique [0002] As people grow older or are affected by diseases, the muscle and collagen tissue of the human body will have different degrees of functional degeneration, causing problems such as gastric reflux, urinary incontinence, and skin depressions. Therefore, people have invented a variety of fillers to fill Depressed skin or stimulate the regeneration of muscle and collagen through foreign substances, such as bovine collagen, hyaluronic acid, etc. But with the passage of time, it was found that these fillers were not filled for a long time. For this reason, people used non-degradable materials in vivo, such as polyvinyl alcohol (PVA), polymethyl methacrylate (PMMA), etc. Made into microspheres as fillers, but these materials will release harmful subst...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K47/34
CPCA61K9/1647A61K9/1682
Inventor 苏红清秦昌张娜李建袁文博赵春华
Owner 山东采采医疗科技有限公司