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Synthesis method of substituted phenoxyacetate compound

A technology of phenoxyacetate and synthesis method, which is applied in the preparation of organic compounds, chemical instruments and methods, and preparation of carboxylic acid esters, and can solve problems such as difficult complete reaction of substituted phenols, high content of free phenols, and high environmental risks , to achieve the effects of low cost, simplified process and reduced environmental risk

Inactive Publication Date: 2019-07-19
鹤岗市英力农化有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to solve the problem that there is a large amount of organic agent consumed in the preparation of substituted phenoxyacetate compounds by the condensation method, the substituted phenol is not easy to react completely, the content of free phenol in the three wastes is high, and there is a high environmental risk. Synthetic method of substituted phenoxyacetate compounds

Method used

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specific Embodiment approach 1

[0014] Specific embodiment one: a kind of synthetic method of substituted phenoxyacetate compound of the present embodiment, it is carried out according to the following steps:

[0015] After mixing the substituted phenol and the haloacetate, the condensation reaction is carried out in a potassium fluoride system condensing agent under the co-catalysis of a phase transfer catalyst and a halogenated hydrocarbon activator to obtain a substituted phenoxyacetate compound.

[0016] The haloacetate of this embodiment is a haloacetate compound.

[0017] The substituted phenoxyacetate compounds of this embodiment are methyl 2,4-dichlorophenoxyacetate, ethyl 2,4-dichlorophenoxyacetate, butyl 2,4-dichlorophenoxyacetate, 2, Isooctyl 4-dichlorophenoxyacetate or isooctyl 2,4-dichlorophenoxyacetate.

[0018] In the direct condensation process of substituted phenols and halogenated acetate compounds in this embodiment, a phase transfer catalyst and a halogenated hydrocarbon activator are us...

specific Embodiment approach 2

[0019] Embodiment 2: This embodiment differs from Embodiment 1 in that: the phase transfer catalyst is one or more of polyethers, crown ethers, and quaternary ammonium compounds.

[0020] Others are the same as in the first embodiment.

[0021] The phase transfer catalyst is preferably one or more of polyethylene glycols, 15-crown-4, benzyltrimethylammonium salt and tetrabutylammonium salt; more preferably polyethylene glycol dimethyl ether , Tetrabutylammonium bromide salt.

specific Embodiment approach 3

[0022] Embodiment 3: This embodiment differs from Embodiment 1 in that: the halogenated hydrocarbon activator is one or more of sodium bromide, potassium bromide, sodium iodide, and potassium iodide.

[0023] Others are the same as in the first embodiment.

[0024] More preferred are potassium bromide and potassium iodide.

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Abstract

The invention discloses a synthesis method of a substituted phenoxyacetate compound, relates to a synthesis method of a compound and aims to solve the problems that during current preparation of the substituted phenoxyacetate compound by a condensation method, a large amount of organic agent is consumed, substituted phenol is unlikely to react completely, the content of free phenol in three wastesis high and a very high environmental risk exists. According to the synthesis method, after the substituted phenol is mixed with haloacetate, a condensation reaction is performed in a potassium fluoride system condensing agent under the synergistic catalysis of a phase transfer catalyst and a halogenated hydrocarbon activator to obtain a substituted phenoxyacetic acid compound. The synthesis method is applied to the field of compound synthesis.

Description

technical field [0001] The invention relates to the technical field of organic synthesis, in particular to a preparation method of substituted phenoxyacetate compounds. Background technique [0002] Substituted phenoxyacetate compounds are a class of important herbicides and intermediates of herbicides, which can be absorbed by the roots, stems and leaves of grass weeds, affecting their normal growth and resulting in death. Because of strong selectivity, rapid action, and little harm to the environment. It is safe and effective in the application process, and the dosage is small, and the cost is low, so it has always been one of the main herbicide varieties in the world. Now the most commonly used are 2,4-D butyl ester, 2,4-D isooctyl ester and 2-methyl-4-chlorophenoxyacetate isooctyl ester, in addition to substituted phenoxyacetate compounds are also produced An important fine chemical intermediate that replaces phenoxyacetic acid. [0003] The synthesis of substituted p...

Claims

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Application Information

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IPC IPC(8): C07C67/31C07C69/712
CPCC07C67/31C07C69/712
Inventor 温立君孙志忠梁朝文
Owner 鹤岗市英力农化有限公司