Viable cell mitochondria G-quadruplex targeted fluorescent probe and application thereof

A fluorescent probe and cell technology, applied in the field of analytical chemistry, can solve problems such as influence, and achieve the effects of small damage, low cytotoxicity, and easy detection and operation.
CN110055054AActive Publication Date: 2019-07-26INST OF CHEM CHINESE ACAD OF SCI
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
INST OF CHEM CHINESE ACAD OF SCI
Publication Date
2019-07-26

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Abstract

The invention discloses novel application of a cyanine dye to viable cell mitochondria G-quadruplex detection. The cyanine dye is a structural compound shown as a formula (I) or a stereoisomer of thecompound shown as the formula (I). A cyanine dye fluorescent probe has advantages of high biocompatibility, low cytotoxicity, low molecular weight and low biological sample damages, and real-time observation of cell samples can be realized without being affected by pH values of cells.
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Description

technical field

[0001] The present invention relates to the field of analytical chemistry, in particular, to fluorescent probes and applications thereof, more specifically, to fluorescent probes, the use of fluorescent probes in fluorescent imaging of mitochondrial G-quadruplexes in living cells, and live cell A method for fluorescence imaging of inner mitochondrial G-quadruplexes. Background technique

[0002] Mitochondria is a double-membrane organelle that exists in most eukaryotic cells, with a diameter of 0.5-1 μm. It is a structure that produces energy in cells and is the main place for cells to perform aerobic respiration. In addition, mitochondria contain a certain amount of genetic material, which has certain effects on many biological behaviors such as apoptosis, cell growth, and cell differentiation. In recent years, a large number of studies have shown that abnormal mitochondrial function is closely related to the occurrence of various human diseases, and this p...

Claims

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