Ultrasonic-assisted preparation of porous bone cement scaffold and preparation method thereof

Abstract

The invention discloses an ultrasonic-assisted preparation of porous bone cement scaffold and a preparation method thereof. The preparation method comprises the following steps of under a low-temperature environment, adding a hectorite solution and a polymer curing solution into calcium phosphate powder in sequence, and uniformly mixing, so as to obtain slurry; extruding the slurry according to apreset shape by an extrusion type 3D (three-dimensional) printer and a coaxial printer head; then, transferring into a constant-temperature and constant-humidity box, and hatching for a period of time, so as to obtain a bone cement three-dimensional scaffold; finally, placing the bone cement three-dimensional scaffold into an acetate solution, and treating by ultrasonic waves for a period of time,so as to obtain the porous bone cement scaffold. The porous bone cement scaffold has the advantages that the shape can be designed so as to meet the requirement of accelerating cell growth; the mechanical property and biology property are good; compared with the prior art, an ultrasonic-assisted perforating method is suitable for the bone cement scaffold which is prepared by 3D printing, the method is simple, the implementation is easy, and the method is suitable for being popularized and applied.

Description

technical field [0001] The invention belongs to the field of 3D printing and biomedical materials, and in particular relates to an ultrasound-assisted preparation of a porous bone cement support and a preparation method thereof. Background technique [0002] Currently, bone repair materials prepared using 3D printing technology are generally non-degradable polymers, such as polymethyl methacrylate (PMMA). Non-absorbable and degradable materials need to be removed by secondary surgery after use, so that patients have the risk of secondary surgery and infection. The resorbable and degradable bone repair material-calcium phosphate bone cement has good biodegradability, but its injection performance is poor, so it is difficult to be directly applied to 3D printing. Vascularization is difficult, and new bone is difficult to grow into. On the other hand, the contact between the material and body fluid is not sufficient, and the degradation rate of the material is slow. At presen...

AI Technical Summary

Problems solved by technology

Non-absorbable and degradable materials require secondary surgery to remove after use, exposing patients to the risk of secondary surgery and infection

The resorbable and degradable bone repair material-calcium phosphate bone cement has good biodegradability, but its injection performance is poor, so it is difficult to be directly applied to 3D printing. Vascularization is difficult, new bone is difficult to grow into, on the other hand, the contact between the material and body fluid is not sufficient, and the degradation rate of the material is slow

At present, the pore-forming method of most bone cements is to add soluble substances such as sodium bicarbonate, sodium chloride grains or sucrose to the calcium phosphate bone cement to remove the pore through dissolution, or to add combustible microspheres to remove through calcination to form pores. , but none of these hole-forming methods are suitable for 3D printing

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