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Synthetic method for hydroxyapatite nanoparticles with spherical morphology

A technology of hydroxyapatite and nanoparticles, applied in the direction of nanotechnology, phosphorus compounds, chemical instruments and methods, etc., can solve the problems of large particle size, poor morphology of hydroxyapatite nanoparticles, harsh reaction conditions, etc., and achieve The effect of uniform shape, novel material selection and simple operation

Active Publication Date: 2019-08-02
HARBIN UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] The purpose of the present invention is to provide a simple, efficient and stable spherical shape hydroxyapatite in order to solve the problems of poor morphology, large particle size and harsh reaction conditions of the hydroxyapatite nanoparticles obtained by the existing synthesis method. Synthesis of Stone Nanoparticles

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  • Synthetic method for hydroxyapatite nanoparticles with spherical morphology
  • Synthetic method for hydroxyapatite nanoparticles with spherical morphology
  • Synthetic method for hydroxyapatite nanoparticles with spherical morphology

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Experimental program
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specific Embodiment approach 1

[0014] Specific implementation mode 1: This implementation mode is a synthesis method of hydroxyapatite nanoparticles with a spherical shape, which is realized according to the following steps:

[0015] 1. The preparation method of carbon quantum dots: (1) measure 0.172g sucrose and dissolve in 500ml deionized water and stir evenly; (2) take 0.01ml concentrated sulfuric acid and dissolve it in 100ml deionized water and stir evenly; (3) take the above-mentioned prepared Pour 0.005ml of concentrated sulfuric acid solution into the above sucrose solution and stir evenly; (4) transfer the above mixed solution into a polytetrafluoroethylene reactor and react at 160°C for 12h, and cool to room temperature to obtain a carbon quantum solution;

[0016] 2. Dissolve the carbon quantum dots prepared above and Tween 80 in 25ml of ethylene glycol aqueous solution, and stir for 30min to obtain a mixed solution;

[0017] 3. Add 5ml of phosphoric acid buffer solution to the mixed solution in ...

specific Embodiment approach 2

[0020] Embodiment 2: This embodiment is different from Embodiment 1 in that the molar ratio of step 2 carbon quantum dots, Tween 80, ethylene glycol and phosphoric acid buffer solution is 0.317:0.063:50:1, other steps and parameters It is the same as the first embodiment.

specific Embodiment approach 3

[0021] Embodiment 3: The difference between this embodiment and Embodiments 1 to 2 is that in step 2, the molar ratio of carbon quantum dots, Tween 80, ethylene glycol, and phosphoric acid buffer solution is 0.317:0.063:48:1. Other steps and parameters are the same as those in Embodiments 1 to 2.

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Abstract

The invention belongs to the field of inorganic materials, in particular relates a synthetic method for the inorganic materials, relates to a simple and feasible method for inventing hydroxyapatite nanoparticles with spherical morphology and can provide a wide space for subsequent applications by controlling the sizes of the hydroxyapatite nanoparticles with the spherical morphology. The hydroxyapatite nanoparticles with the spherical morphology comprises the following preparation steps: taking carbon quantum dots as a template, a phosphate buffer solution as a phosphorus source, and anhydrouscalcium chloride as a calcium source, adding the phosphorus source and the calcium source in an aqueous solution of ethylene glycol containing the carbon quantum dots and taking Tween 80 as a surfactant one by one, reacting under condensate reflux at the temperature of 80 DEG C, then performing centrifugation and drying, finally performing calcination in an inert atmosphere to obtain the hydroxyapatite nanoparticles with the spherical morphology. The synthesized hydroxyapatite nanoparticles with the spherical morphology have good spherical morphology and monodispersity, and the particle sizesof the hydroxyapatite nanoparticles can be modulated between 100nm to 250nm in a controlled manner.

Description

technical field [0001] The invention relates to a method for synthesizing hydroxyapatite nanoparticles with a spherical shape. Background technique [0002] As a new research field in the eleventh century, nanomaterials are a discipline based on material science and nanotechnology as a means. With the vigorous development of science and technology, nanotechnology has gradually matured, and people's understanding of nanomaterials has gradually deepened. Not only can nanoparticles of various shapes be synthesized, but also their growth range can be controlled. Hydroxyapatite has a unique chemical composition. , is favored. Hydroxyapatite is the main inorganic component of human bone tissue. After implanted in the body, free calcium and magnesium ions can be easily absorbed by body tissues and grow new tissues. The currently synthesized hydroxyapatite The shapes of nanoparticles mainly include rod shape, needle point shape, sheet shape, and irregular spherical shape. Experim...

Claims

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Application Information

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IPC IPC(8): C01B25/32B82Y40/00
CPCC01B25/325B82Y40/00C01P2004/32
Inventor 刘献斌邓尚张芯蕊张艳
Owner HARBIN UNIV OF SCI & TECH