Double-layer nano composite film for guiding bone regeneration and preparation method thereof

A guided bone regeneration and nano-composite technology, applied in tissue regeneration, coating, medical science, etc., to achieve the effects of excellent cell adhesion, promotion of bone defect repair, and excellent in vitro degradability

Inactive Publication Date: 2019-08-02
UNIV OF SCI & TECH OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, how to achieve other functions of the ideal GBR membrane at the same time, and how to achieve the unification of its structure and function, is still a major challenge.

Method used

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  • Double-layer nano composite film for guiding bone regeneration and preparation method thereof
  • Double-layer nano composite film for guiding bone regeneration and preparation method thereof
  • Double-layer nano composite film for guiding bone regeneration and preparation method thereof

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preparation example Construction

[0031] In view of the current situation of bone-inducing regeneration membranes, the embodiment of the present invention discloses a method for preparing a double-layer nanocomposite membrane for guiding bone regeneration. The composite membrane prepared by this method has a two-layer structure of a bionic dense layer and a loose porous layer. The combined effect of the structure makes the composite membrane have good mechanical properties, biocompatibility, bacteriostasis and biodegradability. Specifically, the preparation method of the double-layer nanocomposite film described in the present application comprises the following steps:

[0032] A) mixing biocompatible organic polymers and nanomaterials in an aqueous solution to obtain a nanocomposite solution;

[0033] B) subjecting the nanocomposite solution to evaporation to obtain a nanocomposite film;

[0034] C) Spraying a layer of the nanocomposite solution on the surface of the nanocomposite film, and subjecting the ob...

Embodiment 1

[0044] A certain quality of chitosan (CS) is made into a CS aqueous solution, and the mass volume concentration of CS in the solution is 20 mg / ml; after ultrasonically removing air bubbles, the mixed solution is poured into a petri dish, and a single-layer dense film is formed after natural evaporation; The structure, mechanical properties, in vitro degradability, cytocompatibility and antibacterial properties of the obtained single-layer nanocomposite membranes were characterized.

Embodiment 2

[0046] Mix and disperse a certain mass fraction of chitosan (CS) and graphene oxide (GO) into an aqueous solution, ultrasonically crush until completely dispersed, and prepare a CS-GO mixed aqueous solution. The mass volume concentrations of CS and GO in the solution are respectively 20 mg / ml and 0.5mg / ml; the mixed solution was poured into a petri dish after ultrasonic removal of bubbles, and a single-layer dense film was formed after natural evaporation; the structure, mechanical properties, in vitro degradability, and cell phase of the obtained single-layer nanocomposite film Capacitance, antibacterial properties, etc.

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Abstract

The invention provides a preparation method of a double-layer nano composite film for guiding bone regeneration. The preparation method comprises the following steps: A) mixing a biocompatible organicpolymer with a nano material in an aqueous solution to obtain a nano composite solution; B) subjecting the nano composite solution to evaporation to obtain a dense nano composite film; and C) spraying the surface of the nano composite film with a layer of the nano composite solution, and performing low temperature treatment on the obtained product to obtain the double-layer nano composite film. In the application, a biomimetic structural film with good mechanical properties is prepared by using an evaporation self-assembly technique, then a loose porous layer is prepared on the surface of theprepared film by a frozen ice template method, and the multifunctional double-layer nano composite film with good mechanical properties, antibacterial activity, in-vitro degradability and cell adhesion for guiding the bone regeneration can be obtained.

Description

technical field [0001] The invention relates to the technical field of preparation of bionic structure film materials, in particular to a double-layer nanocomposite film for guiding bone regeneration and a preparation method thereof. Background technique [0002] The treatment of bone defects caused by trauma, inflammation, congenital diseases and tumor resection has always been a hot spot in clinical research. Guided bone regeneration (GBR) technique is a common method to achieve bone formation. In the GBR technology, the membrane material is the key factor. It forms a stable space under the membrane by placing the GBR membrane at the bone defect, preventing the growth of connective tissue, giving priority to the growth of bone-forming cells, and fully mobilizing the healing of the tissue itself. ability to achieve bony healing. [0003] According to whether it is degradable or not, GBR membranes commonly used in clinical treatment can be divided into biodegradable membra...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L5/08C08K3/04C08K7/10C08J5/18C08J7/04A61L27/56A61L27/58A61L27/50A61L27/20A61L27/08A61L27/02
CPCC08J5/18A61L27/56A61L27/58A61L27/50A61L27/20A61L27/08A61L27/025C08J2305/08C08J2405/08C08K3/042C08K7/10A61L2430/02C08J7/0427
Inventor 俞书宏高怀岭张开润
Owner UNIV OF SCI & TECH OF CHINA
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