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Applications of turmeric rhizome oil

A technology of essential oil and curcuma, applied in the field of biomedicine to achieve the effects of reduced toxicity, good pharmacokinetic parameters, and improved cognitive function

Inactive Publication Date: 2019-08-16
KUNMING UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Previously, this pharmacological effect has not been reported

Method used

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  • Applications of turmeric rhizome oil
  • Applications of turmeric rhizome oil
  • Applications of turmeric rhizome oil

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0040] The preparation method of the zedoary essential oil of the present invention comprises steam distillation extraction and carbon dioxide supercritical extraction.

[0041] Zedoary essential oil of the present invention is detected by gas chromatography-mass spectrometry instrument, and its component ratio is curzerene (curzerene) (>6%), germacrone (germacrone) (>6%), β- Elemene (β-elemene) (>5%), eucalyptol (>8%), camphor (2-bornanone) (>5%).

Embodiment 1

[0043] Take 100Kg of fresh or dried rhizome of Curcuma phaeocaulis Val., put it in a pile for 2 days, put it in a pile for 2 days, crush it to 50 mesh coarse particles, and soak the coarse particles in 8 times the mass of hydrochloric acid aqueous solution with a pH value of 5.0 , leached overnight. 0.8% cellulase and 0.3% pectinase were added to the extraction mixture by mass percentage, and enzymolysis was carried out at 37° C. for 2.5 hours. Put the above sample and its mixture into a steam distillation extraction apparatus, reflux extraction at 110°C for 7 hours, collect the distillate, cool it to room temperature, and place it in an oil-water separator for separation. The oil layer was dried with anhydrous sodium sulfate and separated to obtain zedoary essential oil.

Embodiment 2

[0045] Take Guangxi Curcuma kwangsiensis S.G.Lee et C.F.Liang fresh or dry rhizome 120Kg, put it in a heap for 2 days, put it in a heap for 2 days, crush it to 50 mesh coarse particles, soak the coarse particles in 8 mass times the pH value 5.0 hydrochloric acid aqueous solution, leaching overnight. 0.8% cellulase and 0.3% pectinase were added to the extraction mixture by mass percentage, and enzymolysis was carried out at 37° C. for 2.5 hours. Put the above sample and its mixture into a steam distillation extraction apparatus, reflux extraction at 110°C for 7 hours, collect the distillate, cool it to room temperature, and place it in an oil-water separator for separation. The oil layer was dried with anhydrous sodium sulfate and separated to obtain zedoary essential oil.

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Abstract

The invention discloses applications of turmeric rhizome oil. The applications include an application of the turmeric rhizome oil in preparation of drugs for treating or preventing brain dysfunction,and an application of the turmeric rhizome oil in preparation of health products for relieving the brain dysfunction. The invention discovers for the first time a new use of the turmeric rhizome oil in drugs or massive health products displaying activity in the brain dysfunction of experimental animals, and discovers for the first time that the turmeric rhizome oil or any compound containing the turmeric rhizome oil can relieve animals' symptoms of the brain dysfunction such as Alzheimer's Disease and depression in an in-vivo model of the animals. Compared with existing drugs for treating thebrain dysfunction, the turmeric rhizome oil or any combination thereof has the advantages that the turmeric rhizome oil or any combination thereof has the mechanism of inhibiting cholinesterase and regulating the polymolecular synergistic effect of neurotransmitters on multiple targets, has good pharmacological parameters, and easily penetrates blood brain barriers, thereby having toxicological safety, metabolic stability, long half-life and / or small side effect.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to the use of zedoary essential oil in the preparation of medicines and health products for treating and preventing brain function and its disorders. Background technique [0002] Zingiberaceae Curcuma is currently mainly cultivated in Sichuan, Guangxi, Yunnan and other places. The dried rhizome of Zedoary Curcuma is an important traditional Chinese medicinal material with a long history of being used as medicine. Zedoary was first recorded in "On the Properties of Medicine", and it has been included in the "Pharmacopoeia of the People's Republic of China" over the years. Curcuma has the effects of promoting qi and breaking blood, eliminating stagnation and relieving pain. It is often used to treat symptoms such as lumps in the abdomen, blood stasis, amenorrhea, chest pain and heartache, and food stagnation. The volatile oil rich in the rhizome of Zedoary Curcuma is one of its...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066A61P25/00A61P25/24A61P25/22A61P25/20A61P25/28A61P25/08A61P25/18A61P9/10A61P25/14A61P25/16A61K8/92A61Q19/00A61Q19/10A61L9/013C11B9/02
CPCA61K36/9066A61P25/00A61P25/24A61P25/22A61P25/20A61P25/28A61P25/08A61P25/18A61P9/10A61P25/14A61P25/16A61K8/922A61Q19/00A61Q19/10A61L9/013C11B9/02C11B9/027C11B9/025A61K2800/10
Inventor 许敏陈淑霞韩佳欣李海舟杨崇仁
Owner KUNMING UNIV OF SCI & TECH
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