Peelable porous antibacterial biological foam dressing and preparation method thereof

A bio-foam and peel-off technology, applied in local antibacterial agents, pharmaceutical formulations, drug combinations, etc., can solve the problems of reducing antibacterial and wound healing effects, secondary damage to healthy skin, unfavorable dressing replacement and peeling, etc.

Pending Publication Date: 2019-08-16
JIANGSU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, biological dressings based on bioadhesion also have shortcomings, such as their chemical inertness often leads to detachment from damaged tissues, reducing their antibacterial and healing effects
In addition, the general covalent chemical bonding is irreversible, which may cause secondary damage to healthy skin when removing the wound dressing, which is not conducive to the later replacement and peeling of the dressing

Method used

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  • Peelable porous antibacterial biological foam dressing and preparation method thereof
  • Peelable porous antibacterial biological foam dressing and preparation method thereof
  • Peelable porous antibacterial biological foam dressing and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Example 1: Preparation of a porous antibacterial biofoam dressing lacking Pickering particles (comparative material: dressing #1)

[0038] (1) Synthesis of methacrylic acid modified chondroitin sulfate (CSMA)

[0039] First, dissolve chondroitin sulfate sodium salt (CS, 5 g) in 100 mL phosphate buffered saline (PBS, pH=7.4), and then add 10 mL glycidyl methacrylate. The reaction solution was then vigorously stirred at room temperature for 15 days. The resulting product was extracted by precipitation with acetone. In order to remove residual glycidyl methacrylate, the white product was redissolved and extracted with chloroform. Finally, the aqueous phase was collected and concentrated, precipitated with acetone again, and the product was freeze-dried to obtain vinyl-modified chondroitin sulfate (CSMA), which was stored at -20°C for use.

[0040] (2) Preparation of graphene-supported zinc-doped copper oxide (Zn-CuO@GO) composite material

[0041] 0.15 g of copper acetate and 0...

Embodiment 2

[0044] Example 2: Preparation of a porous antibacterial bio-foam dressing lacking boric acid (comparative material: dressing #2)

[0045] (1) Synthesis of methacrylic acid modified chondroitin sulfate (CSMA)

[0046] First, dissolve chondroitin sulfate sodium salt (CS, 7 g) in 100 mL phosphate buffered saline (PBS, pH=7.4), and then add 10 mL glycidyl methacrylate. The reaction solution was then vigorously stirred at room temperature for 15 days. The resulting product was extracted by precipitation with acetone. In order to remove residual glycidyl methacrylate, the white product was redissolved and extracted with chloroform. Finally, the aqueous phase was collected and concentrated, precipitated with acetone again, and the product was freeze-dried to obtain vinyl-modified chondroitin sulfate (CSMA), which was stored at -20°C for use.

[0047] (2) Preparation of graphene-supported zinc-doped copper oxide (Zn-CuO@GO) composite material

[0048] 0.15 g of copper acetate and 0.055 g o...

Embodiment 3

[0051] Example 3: Preparation of porous antibacterial bio-foam dressing (bio-foam dressing #3)

[0052] (1) Synthesis of methacrylic acid modified chondroitin sulfate (CSMA)

[0053] First, dissolve chondroitin sulfate sodium salt (CS, 10 g) in 100 mL of phosphate buffered saline (PBS, pH=7.4), and then add 10 mL of glycidyl methacrylate. The reaction solution was then vigorously stirred at room temperature for 15 days. The resulting product was extracted by precipitation with acetone. In order to remove residual glycidyl methacrylate, the white product was redissolved and extracted with chloroform. Finally, the aqueous phase was collected and concentrated, precipitated with acetone again, and the product was freeze-dried to obtain methacrylic acid-modified chondroitin sulfate (CSMA), which was stored at -20°C for use.

[0054] (2) Preparation of graphene-supported zinc-doped copper oxide (Zn-CuO@GO) composite material

[0055] 0.15 g of copper acetate and 0.055 g of zinc acetate w...

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Abstract

The invention relates to a peelable porous antibacterial biological foam dressing and a preparation method thereof, which belong to the technical field of preparation of a biological function material. The method designs a non-invasive peeling porous antibacterial biological foam dressing by a Zn-CuO@GO stable Pickering high internal phase emulsion template, the porous antibacterial biological dressing not only can effectively adhere to the wound, but also can significantly accelerate wound healing, and at the same time adhere to the wound through reversible polyvalent phenylboronic acid/cis-diol interaction and achieve painless peeling under the action of glucose; the Pickering high internal phase emulsion template imparts a porous structure to the biological foam dressing, cell interaction and nutrient exchange can be promoted, the use of active phenylboronic acid functional monomers is maximized; and the use of Zn-CuO@GO enhances the antibacterial effect of the biological foam dressing.

Description

Technical field [0001] The invention relates to a peelable porous antibacterial biological foam dressing and a preparation method thereof, and belongs to the technical field of biological functional material preparation. Background technique [0002] In recent years, inspired by the adhesion mechanisms of mussels, geckos and spider webs, scientists have developed a variety of biomimetic adhesive biological dressings, which are used for regeneration of damaged tissues and wound healing. In clinical practice, this type of biological dressing generally needs to be adhered to different tissues through a tissue adhesive, so that the biological dressing is closely combined with the damaged part, thereby promoting tissue regeneration. For example, the injectable hydrogel is injected into the damaged area before the gel is formed, and the natural molecular active groups such as sulfhydryl and amine groups present in the wound are used to fix the dressing to the wound through the covalent...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/42A61L15/20A61L15/18A61L15/28A61L15/26A61L15/46A61K9/70A61P31/02A61P17/02
CPCA61K9/7023A61L15/18A61L15/20A61L15/26A61L15/28A61L15/42A61L15/425A61L15/46A61L2300/236A61L2300/404A61L2300/41A61L2300/412A61L2400/12A61P17/02A61P31/02C08L5/08C08L71/02
Inventor 刘金鑫潘建明吴润润
Owner JIANGSU UNIV
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