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Preparation method of interaction network compound Bletilla striata dressing

A technology of network compounding and bletilla striata, applied in the field of biomedicine, can solve the problems of poor mechanical properties, different structures, and different components of gauze, and achieve the effects of ensuring mechanical strength, good adhesion to wounds, and guaranteed reliability

Active Publication Date: 2019-09-06
WUHAN TEXTILE UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the mechanical properties of the obtained gauze are relatively poor, and there is a problem of difficulty in taking
[0004] Existing bletilla striata dressings will encounter the problem of blood on the gloves worn by doctors when they are used in surgical operations, which will cause the bletilla striata dressings to dissolve and stick to the gloves, which is not conducive to the application of bletilla striata dressings on the wound and reduces the hemostatic efficiency of bletilla striata dressings
The composition and structure of each layer of traditional multi-layer dressings are different, which limits the application range of dressings

Method used

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  • Preparation method of interaction network compound Bletilla striata dressing

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preparation example Construction

[0031] A preparation method of interactive network composite bletilla striata dressing, the preparation method is carried out according to the following steps:

[0032] a Preparation of Bletilla striata polysaccharide casting solution

[0033] The bletilla striata polysaccharide solution is prepared by dissolving the bletilla striata polysaccharide in water to prepare a bletilla striata polysaccharide solution with a mass fraction of 3-10%, and placed in a vacuum state with a vacuum degree of 0.1-0.5 MPa to remove air bubbles to obtain a bletilla striata polysaccharide casting solution for future use.

[0034] b Preparation of dressing layer

[0035] Take part of the Bletilla striata polysaccharide casting solution prepared in step a and pour it into the groove of the flat mold, and use the freezing method to completely freeze the Bletilla striata polysaccharide casting solution in the flat mold to form a 3-8mm thick Bletilla striata polysaccharide film. The molded film is fr...

Embodiment 1

[0050] a Preparation of Bletilla striata polysaccharide casting solution

[0051] Dissolving Bletilla striata polysaccharide in water to prepare a Bletilla striata polysaccharide solution with a mass fraction of 3%, and placing it in a vacuum with a degree of vacuum of 0.1 MPa to remove air bubbles to obtain a Bletilla striata polysaccharide casting solution for future use.

[0052] b Preparation of dressing layer

[0053] Take part of the bletilla striata polysaccharide casting solution prepared in step a and pour it into the groove of the flat mold, and freeze the bletilla striata polysaccharide casting solution in the flat mold completely by freezing to form a 3 mm thick bletilla striata polysaccharide film. Freeze-dry in an environment with a temperature of -10°C and a vacuum of 1 Pa, and take it out after 24 hours to obtain the adhesive layer dressing 2.

[0054] Wherein, the length of the above-mentioned flat mold groove is 10mm, the width is 10mm, and the height is 5mm...

Embodiment 2

[0065] a Preparation of Bletilla striata polysaccharide casting solution

[0066] Dissolving the Bletilla striata polysaccharide in water to prepare a Bletilla striata polysaccharide solution with a mass fraction of 10%, and placing it in a vacuum state with a vacuum degree of 0.5 MPa to remove air bubbles to obtain a Bletilla striata polysaccharide casting solution for future use.

[0067] b Preparation of dressing layer

[0068] Take part of the bletilla striata polysaccharide casting solution prepared in step a and pour it into the groove of the flat mold, and freeze the bletilla striata polysaccharide casting solution in the flat mold completely by freezing to form a bletilla striata polysaccharide film with a thickness of 8mm. Freeze-dry in an environment with a temperature of -60°C and a vacuum of 20 Pa, and take it out after 48 hours to obtain the adhesive layer dressing 2.

[0069] Wherein, the length of the above-mentioned flat mold groove is 200mm, the width is 100m...

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Abstract

The invention relates to a preparation method of an interaction network compound Bletilla striata dressing and belongs to the technical field of biological medicine. The preparation method includes: pouring part of prepared Bletilla striata polysaccharide casting solution into a flat plate die groove, using a freezing method to freeze the Bletilla striata polysaccharide casting solution into a Bletilla striata polysaccharide film, performing freeze drying to obtain an attaching layer dressing, standing the attaching layer dressing at low temperature for a certain period of time, pouring a surface casting solution subjected to acetyl removing using sodium hydroxide on the attaching layer dressing, freezing to integrate the surface casting solution and the attaching layer dressing, and performing freeze drying to obtain the interaction network compound Bletilla striata dressing. An interaction network compound structure is formed between the attaching layer dressing and the surface dressing, the two dressing layers are reliably connected, and the Bletilla striata dressing is good in mechanical performance. The interaction network compound Bletilla striata dressing prepared by the method has the advantages that the problem that the Bletilla striata dressing is hard to use is solved, and the interaction network compound Bletilla striata dressing can be completely degraded and absorbed and has no side effects on a wound.

Description

technical field [0001] The invention relates to a preparation method of an interactive network composite bletilla striata dressing, belonging to the technical field of biomedicine. Background technique [0002] In the clinical use of surgery, the rapid hemostasis of the wound has an important impact on the postoperative recovery of patients. Bletilla striata is a hemostatic material in traditional Chinese medicine, and its tuber extract, Bletilla striata polysaccharide, has excellent hemostasis and strong antibacterial properties, and is a water-soluble substance. Bletilla striata polysaccharide, as the main functional component of Bletilla striata tubers, has been widely used in the field of wound dressings because of its excellent astringent and hemostatic, antibacterial and anti-inflammatory effects, as well as its good biological properties, biodegradability, and non-toxic side effects. [0003] The Chinese patent publication number is CN106075551A, the publication date...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/42A61L15/28
CPCA61L15/28A61L15/42A61L15/425A61L2300/232A61L2300/412C08L5/00
Inventor 杨红军王晗刘昌俊许愿张骞陈欣庄燕徐卫林
Owner WUHAN TEXTILE UNIV
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