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Titanium and alloy of titanium with bone promoting effect as well as preparation method and application of titanium and alloy of titanium

A technology of titanium alloys and alloy materials, which is applied in the field of surface modification of titanium and its alloy materials and its preparation, can solve the problems of poor bone tissue integration and poor bone performance, and achieve the advantages of cell adhesion, osteoinductive ability, and The effect of good application prospects

Active Publication Date: 2019-09-10
SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In order to solve the defects of existing medical titanium and its alloy materials such as poor bone-promoting performance and poor integration with bone tissue, the present invention provides a kind of titanium alloy with good microenvironment alkaline regulation performance, biocompatibility and bone-promoting performance. Surface modified titanium material and its preparation method and application

Method used

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  • Titanium and alloy of titanium with bone promoting effect as well as preparation method and application of titanium and alloy of titanium
  • Titanium and alloy of titanium with bone promoting effect as well as preparation method and application of titanium and alloy of titanium
  • Titanium and alloy of titanium with bone promoting effect as well as preparation method and application of titanium and alloy of titanium

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] Pure titanium whose length, width, and height are 10mm, 10mm, and 1mm, respectively, are treated with mixed acid (HF: HNO 3 :H 2 (0=1:5:34) and ultrasonic cleaning with deionized water twice, each time for 8 minutes. Mg in hydrothermal medium 2+ with Fe 3+ The total concentration is 0.05mol / L, where c(Mg 2+ ): c(Fe 3+ )=4:1, the titration solution is a mixed solution of sodium hydroxide and sodium bicarbonate, and c(NaOH):c(NaHCO 3 )=3:1, c(NaHCO 3 )=1mol / L, the pH value of the solution after titration is 9.5, and the stirring time is 30 minutes. The pH value of the solution after titration is 9.5. The aging time is 2 hours. The time is 16 hours, and the filling degree of the reactor is 33.33%.

[0051] figure 1 (b, e) are the scanning electron micrographs and EDS spectra of the samples obtained through modification in this embodiment. It can be seen from the figure that the treated surface is a sheet-like nanostructure, and Mg and Fe elements exist on the surf...

Embodiment 2

[0053] Pure titanium whose length, width, and height are 10mm, 10mm, and 1mm, respectively, are treated with mixed acid (HF: HNO 3 :H 2 (0=1:5:34) and ultrasonic cleaning with deionized water twice, each time for 8 minutes. Mg in hydrothermal medium 2+ with Fe 3+ The total concentration is 0.05mol / L, where c(Mg 2+ ): c(Fe 3+ )=2:1, the titration solution is a mixed solution of sodium hydroxide and sodium bicarbonate, and c(NaOH):(NaHCO 3 )=3:1, c(NaHCO 3 )=1mol / L, the pH value of the solution after titration was 9.5, and the stirring time was 30 minutes. The pH value of the solution after titration was 9.5. The aging time was 2 hours. After 16 hours, the filling degree of the reactor was 33.33%.

[0054] figure 1(c, f) are the scanning electron micrographs and EDS spectra of the samples obtained through modification in this embodiment. It can be seen from the figure that the surface of the treated titanium sheet has a sheet-like nanostructure, and the distribution is ...

Embodiment 3

[0056] The modified samples obtained in Example 1 and Example 2 were subjected to an ion release test. The test sample was soaked in 10% PBS solution for 1 day, 4 days, 7 days, 14 days, 21 days and 28 days. Spectroscopy (ICP-AES) was used to test the release of magnesium ions and iron ions when the material was soaked for different times.

[0057] Figure 5 A and b in the figure respectively show the pattern of the release of magnesium ions and iron ions as a function of immersion time of the samples after the modified treatment of the present invention soaked in 10% PBS solution for different times. The modified film will be hydrolyzed in a liquid environment, thereby releasing metal ions. As can be seen from the figure, the modified samples obtained in Example 1 and Example 2 soaked for different times released Mg 2+ There was no significant difference in the amount of Fe 3+ There was no significant difference in the amount of .

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Abstract

The invention provides titanium and alloy of the titanium with a bone promoting effect as well as a preparation method and application of the titanium and the alloy of the titanium. The surface-modified titanium and an alloy material thereof comprise the titanium or a titanium alloy material and a magnesium-iron layered double-metal hydroxide film formed on the surface of the titanium or the titanium alloy material. The surface-modified titanium and the alloy material thereof have good microenvironment alkalinity regulation performance, biocompatibility and bone induction capability.

Description

technical field [0001] The invention relates to a surface-modified titanium and its alloy material, its preparation method and application, in particular to a method for surface modification of titanium and its alloy material by hydrothermal treatment, belonging to the technical field of surface modification of metal materials . Background technique [0002] Titanium and its alloys have the advantages of strong corrosion resistance, good biocompatibility, elastic modulus close to that of bone tissue, and non-magnetic properties, and have been widely used as hard tissue repair and replacement materials (Progress in Materials Science 2009, 54: 397 -425). However, titanium and its alloy materials are biologically inert materials, which are not firmly combined with human bone tissue, and are prone to loosening, resulting in implant failure. Therefore, it is of great social and research significance to modify its surface to have good osteoinductive ability. [0003] A large nu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C23C18/12A61L27/06A61L27/30A61L27/50
CPCC23C18/1204A61L27/06A61L27/306A61L27/50A61L2430/02A61L2400/18
Inventor 刘宣勇李倩雯王东辉
Owner SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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