Method for continuously preparing methyl anthranilate
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A technology for methyl anthranilate and anthranilic acid, which is applied in the field of organic compound preparation technology, can solve the problems of low purity and yield of methyl anthranilate, environmental pollution, etc., and achieve high product synthesis efficiency and improved Effect of Purity and Yield
Inactive Publication Date: 2019-09-13
SHENZHEN E ZHENG TECH
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[0005] The object of the present invention is to provide a kind of method for continuously preparing methyl anthranilate, to solve the purity and the yield of methyl anthranilate existing in the prior art are not high, the problem of serious environmental pollution
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Embodiment 1
[0043] Pour the methanol solution of anthranilic acid and the concentrated sulfuric acid solution into the microchannel reactor respectively, and the two solutions are preheated by the preheating tube 3 and then mixed and then flow into the reaction tube 4 for reaction, and the reaction in the reaction tube 4 is set. The temperature is 65° C., the residence time of the methanol solution of anthranilic acid and the concentrated sulfuric acid solution in the microchannel reactor is 1 min, and the conversion rate of the methyl anthranilate flowing out from the mixed reaction chamber 1 is 90%.
Embodiment 2
[0045] Pour the methanol solution of anthranilic acid and the concentrated sulfuric acid solution into the microchannel reactor respectively, and the two solutions are preheated by the preheating tube 3 and then mixed and then flow into the reaction tube 4 for reaction, and the reaction in the reaction tube 4 is set. The temperature is 75° C., the residence time of the methanol solution of anthranilic acid and the concentrated sulfuric acid solution in the microchannel reactor is 1 min, and the conversion rate of the methyl anthranilate flowing out from the mixed reaction chamber 1 is 98%.
Embodiment 3
[0047] Pour the methanol solution of anthranilic acid and the concentrated sulfuric acid solution into the microchannel reactor respectively, and the two solutions are preheated by the preheating tube 3 and then mixed and then flow into the reaction tube 4 for reaction, and the reaction in the reaction tube 4 is set. The temperature is 85° C., the residence time of the methanol solution of anthranilic acid and the concentrated sulfuric acid solution in the microchannel reactor is 1 min, and the conversion rate of the methyl anthranilate flowing out from the mixing reaction chamber 1 is 100%.
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Abstract
The invention provides a method for continuously preparing methyl anthranilate, belonging to the technical field of preparation processes for organic compounds. The method comprises the following concrete steps: separately pouring a methanol solution of anthranilic acid and a concentrated sulfuric acid solution into a mixed reaction chamber of a microchannel reactor, and carrying out a preheatingreaction in the mixed reaction chamber to form a mixed solution having methyl anthranilate; and neutralizing a sodium hydroxide solution and the mixed solution, and carrying out cooling to allow methyl anthranilate to be precipitated. According to the invention, the methanol solution of anthranilic acid and concentrated sulfuric acid are separately injected into the mixed reaction chamber of the microchannel reactor; the concentrated sulfuric acid produces dehydration and catalysis effects and can promote the reaction of anthranilic acid with methanol to form methyl anthranilate, so the product can be obtained in one step without a solvent reaction, no additional post-treatment procedure is needed, and environment protection is realized; the concentrated sulfuric acid solution can be neutralized by the sodium hydroxide solution, which is beneficial for improving the purity and yield of methyl anthranilate, and product synthesis efficiency is high.
Description
technical field [0001] The invention belongs to the technical field of organic compound preparation technology, and more specifically relates to a method for continuously preparing methyl anthranilate. Background technique [0002] Methyl anthranilate is an important intermediate for dyes, medicines, pesticides, spices and other products, and is widely used in the fields of medicine, pesticides, spices processing, and fine chemicals. In terms of dyes, it is used to manufacture azo dyes, anthraquinone dyes, and indigo dyes; in medicine, it is used to manufacture antiarrhythmic drugs changroline, vitamin L, non-steroidal anti-inflammatory analgesics mefenamic acid, Yantongjing, non-barbiturate hypnotic methaphenone, strong tranquilizer Telden; it can also be used as a chemical reagent, and can be used as a complex reagent for the determination of cadmium, cobalt, mercury, magnesium, nickel, lead, zinc and cerium, etc. , and 1-naphthylamine can be used to determine nitrite. I...
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