Cellulose porous membrane, and preparation method thereof

A porous membrane and cellulose technology, applied in the field of cellulose materials, can solve the problems of uncontrollable pore size, limit the application of cellulose materials, and fail to meet the needs of cell culture, and achieve simple and effective preparation methods, low cost, and wide application range Effect

Inactive Publication Date: 2019-09-17
SHAANXI UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the cellulose membrane prepared by dissolution regeneration, solvent vapor treatment and other methods has a dense structure, and the pore size is often less than 20 μm, and the pore size is uncontrollable, which cannot meet the needs of cell culture, which greatly limits the application of cellulose materials in the field of thin films.

Method used

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  • Cellulose porous membrane, and preparation method thereof
  • Cellulose porous membrane, and preparation method thereof
  • Cellulose porous membrane, and preparation method thereof

Examples

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preparation example Construction

[0028] (1) Preparation of cellulose solution: weigh 2-5 g of microcrystalline cellulose, add 15-30 mL of N,N-dimethylacetamide (DMAC), stir and preheat at 120-150°C. After 0.5-1h, cool to room temperature, add 5-10g of lithium chloride (LiCl) and 70-85mL of DMAC, heat and stir at 50-80°C for about 0.5-1h until the microcrystalline cellulose is dissolved.

[0029] Among them, Li in LiCl / DMAC solvent + Form a complex with the carbonyl group of DMAC, and Cl - It forms hydrogen bonds with the hydroxyl groups of cellulose, destroying the association between cellulose molecules and making it completely solvated.

[0030] (2) Preparation of cellulose porous membrane: take 3 mL of dissolved cellulose solution, add 2 to 5 g of sodium chloride particles of different sizes at room temperature, and stir evenly. Spread the mixed solution evenly in a petri dish for about 2-4mm, pre-gel at 30-60°C for 0.5-1h, then dissolve the solvent and sodium chloride in the solution with deionized wate...

Embodiment 1

[0033] (1) Preparation of cellulose solution

[0034] a. Weigh 5 g of microcrystalline cellulose, add 20 mL of DMAC, stir and preheat at 150° C. for 1 h to activate it.

[0035] b. Cool the activated cellulose to room temperature, add 10 g lithium chloride and 80 mL DMAC, heat and stir at 60° C. for 1 h until the cellulose is fully dissolved.

[0036] c. Store the dissolved cellulose at room temperature.

[0037] (2) Preparation of cellulose porous membrane

[0038] a. Take 3mL of cellulose solution, add 3g of sodium chloride whose particle size is less than 45μm, stir well and mix well.

[0039] b. Spread the mixed solution on a Petri dish about 2 mm, and pre-gel in an oven at 60°C for 30 minutes.

[0040] c. The pre-gelled film is subjected to solvent exchange in deionized water to dissolve DMAc and sodium chloride therein, and the exchange is continued for 24 hours.

[0041] d. The wet cellulose membrane was frozen in a freeze dryer at -20° C. for 1 hour, and dried to f...

Embodiment 2

[0044] (1) Preparation of cellulose solution

[0045] a. Weigh 3g microcrystalline cellulose, add 30mL DMAC, stir and preheat at 150°C for 0.5h to activate it.

[0046] b. Cool the activated cellulose to room temperature, add 7g lithium chloride and 70mL DMAC, heat and stir at 80°C for 0.5

[0047] h until the cellulose is fully dissolved.

[0048] c. Store the dissolved cellulose at room temperature.

[0049] (2) Preparation of cellulose porous membrane

[0050] a. Take 3mL of cellulose solution, add 2g of sodium chloride whose particle size is less than 75μm, stir well and mix well.

[0051] b. Spread the mixed solution on a petri dish about 4 mm, and pre-gel in an oven at 30° C. for 1 hour.

[0052] c. The pre-gelled film is subjected to solvent exchange in deionized water to dissolve DMAC and sodium chloride therein, and the exchange is continued for 24 hours.

[0053] d. The wet cellulose membrane was frozen in a freeze dryer at -20° C. for 1 hour, and dried to form ...

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Abstract

The invention relates to a cellulose porous membrane, and a preparation method thereof. The preparation method comprises following steps: microcrystalline cellulose is added into organic solvent A, an obtained mixture is subjected to stirring preheating at 150 DEG C, and then is cooled to room temperature, lithium chloride and organic solvent B are added, stirring is carried out at 60 DEG C until microcrystalline cellulose is dissolved so as to obtain a cellulose solution; a pore forming agent which is not soluble in the organic solvent A and the organic solvent B is added into the cellulose solution, and uniform stirring is carried out so as to obtain a mixed solution; the mixed solution is subjected to pre-gelling, a solvent C capable of dissolving the pore forming agent is added for solvent exchange, when the pore forming agent is dissolved in the solvent C completely, the solvent C is removed, and drying is carried out so as to obtain the cellulose porous membrane. The pore diameter of the cellulose porous membrane is larger than 20<mu>m, and ranges from 23 to 46<mu>m; the porosity ranges from 77 to 91%; the pore diameter is controllable, so that cell culture requirements are satisfied.

Description

technical field [0001] The invention belongs to the field of cellulose materials, and in particular relates to a cellulose porous membrane and a preparation method thereof. Background technique [0002] As the natural polymer compound with the most abundant reserves in nature, cellulose has the advantages of being renewable, biodegradable, good biocompatibility, cheap and easy to obtain, etc. In the current energy crisis and increasingly severe environmental problems, cellulose is considered It is an important raw material in the field of chemical industry and new material development in the future. The regenerated cellulose porous membrane with micro-nano structure prepared by dissolving and regenerating cellulose has the characteristics of safety, non-toxicity, biodegradability, and good permeability. It has shown great applications in optical devices, biomaterials, and chemical catalysis. potential for wide application. The preparation methods of porous cellulose membra...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01D71/10B01D67/00
CPCB01D67/0002B01D71/10
Inventor 张素风刘丽娜唐蕊华李菲周浩刘佳尧
Owner SHAANXI UNIV OF SCI & TECH
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