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Leonurine phenolic acid ion salt and preparation method and application thereof

A technology of leonurine phenolic acid and oxalicine phenolic acid is applied in the field of leonurine phenolic acid ion salt and preparation thereof, and achieves the effects of enhancing anti-oxidation, good solubility and high purity

Active Publication Date: 2019-09-20
中科萱嘉医养(珠海)健康科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there is no related report in the prior art

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  • Leonurine phenolic acid ion salt and preparation method and application thereof
  • Leonurine phenolic acid ion salt and preparation method and application thereof
  • Leonurine phenolic acid ion salt and preparation method and application thereof

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Embodiment 1

[0045] Embodiment 1 of the present invention is: a preparation method of motherwortine salicylate ion salt, comprising the following steps:

[0046] (1) Setting of reaction conditions

[0047] Take by weighing 1.38g salicylic acid (10mmol), add 20mL deionized water solvent, pass into N 2 , so that the whole reaction is at N 2 To carry out under atmosphere, place the reaction vessel in an ice-water bath (0°C), keep the reaction temperature at around 0°C, and shield the reaction vessel to ensure that the reaction is carried out under light-shielding conditions.

[0048] (2) Preparation of Leonurine Salicylate Ion Salt

[0049] Take by weighing 3.11g Leonurine (10mmol), the mol ratio of salicylic acid and Leonurine is 1:1, a small amount of multiple rapid additions to the reaction vessel to ensure that the N 2 The atmosphere and reaction real-time temperature are around 0°C. After the addition was complete, the ice-salt bath was removed, and the reaction was carried out at ro...

Embodiment 2

[0052] Embodiment 2 of the present invention is: a preparation method of motherwortine caffeic acid ion salt, comprising the following steps:

[0053] (1) Setting of reaction conditions

[0054] Weigh 1.80g caffeic acid (10mmol), add 20mL deionized water solvent, pass through N 2 , so that the whole reaction is at N 2 To carry out under atmosphere, place the reaction vessel in an ice-water bath (0°C), keep the reaction temperature at around 0°C, and shield the reaction vessel to ensure that the reaction is carried out under light-shielding conditions.

[0055] (2) Preparation of Leonurine Caffeic Acid Ion Salt

[0056] Weigh 3.11g of motherwortine (10mmol), the molar ratio of caffeic acid to motherwortine is 1:1, and add a small amount of it to the reaction vessel quickly several times to ensure that the N 2 The atmosphere and reaction real-time temperature are around 0°C. After the addition was complete, the ice-salt bath was removed, and the reaction was carried out at r...

Embodiment 3

[0059] Embodiment three of the present invention is: a preparation method of leonurine syringic acid ion salt, comprising the following steps:

[0060] (1) Setting of reaction conditions

[0061] Take by weighing 1.98g syringic acid (10mmol), add 20mL deionized water solvent, pass into N 2 , so that the whole reaction is at N 2 To carry out under atmosphere, place the reaction vessel in an ice-water bath (0°C), keep the reaction temperature at around 0°C, and shield the reaction vessel to ensure that the reaction is carried out under light-shielding conditions.

[0062] (2) Preparation of Leonurine Syringate Ion Salt

[0063]Take by weighing 3.11g leonurine (10mmol), the mol ratio of syringic acid and leonurine is 1:1, a small amount of multiple rapid additions to the reaction vessel to ensure that N 2 The atmosphere and reaction real-time temperature are around 0°C. After the addition was complete, the ice-salt bath was removed, and the reaction was carried out at room te...

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Abstract

The invention discloses leonurine phenolic acid salt and a preparation method and application thereof. The leonurine phenolic acid salt comprises anions and cations, the anions are phenolic acid ions and the cations are leonurine ions. The preparation method includes the steps of S1, adding phenolic acid to a solvent in an atmosphere of protective gas (preferably nitrogen or inert gas) and ice-water bath; S2, adding leonurine to the phenolic acid for neutral reaction to obtain a solution containing the leonurine phenolic acid salt which is applicable to preparation of drugs or cosmetics. The lenourine phenolic acid ion salt, which has various functions of the leonurine and phenolic salt has the effect of enhancing oxidation resistance compared with a phenolic acid monomer, has better solubility in both oil phase and water phase.

Description

technical field [0001] The invention relates to the field of daily cosmetics, in particular to a leonurine phenolic acid ion salt and a preparation method and application thereof. Background technique [0002] Leonurine, the chemical name is 3,5-dimethoxy-4-hydroxy-benzoic acid (4-guanidino)-1-butyl ester, which is widely found in the leaves of Leonurus chinensis or in the whole grass of Leonurus and Mugwort , has various effects such as promoting blood circulation and removing blood stasis, diuresis and detumescence. Specifically, the pharmacological effects of motherwort mainly have five aspects: 1) excitatory effects on the uterus of various animals, and the uterine contraction of motherwort can last for several hours, but it can be recovered after washing; 2) the effect on the circulatory system Small doses of motherwort have enhanced contraction of the isolated frog heart, and when used in large amounts, it is inhibited. Leonurine has obvious dilation of blood vessels ...

Claims

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Application Information

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IPC IPC(8): A61K31/235A61K31/192A61K31/60A61P17/10A61K8/43A61K8/368A61K8/365A61Q19/08
CPCA61K31/235A61K31/192A61K31/60A61P17/10A61K8/43A61K8/368A61K8/365A61Q19/08A61K2300/00
Inventor 张嘉恒刘凌雯袁菊懋余明远王岩
Owner 中科萱嘉医养(珠海)健康科技有限公司
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