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Cannabidiol CBD nano-emulsion and preparation method thereof

A technology of cannabidiol and nanoemulsion, which is applied in the biological field, can solve the problems of no application value, easy oxidation of cannabidiol CBD, and changes in drug efficacy, so as to improve bioavailability, reliable technical support, and expand the scope of application Effect

Inactive Publication Date: 2019-09-24
云南辰锦威生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the different polarity of the molecule, it cannot be dissolved in water. Changing the result can make it soluble in water, but this will cause the physical and chemical properties of the original substance to change, and its drug effect will also change. This is also true in actual work. no application value
Therefore, how to overcome the problem that cannabidiol CBD is extremely easy to oxidize is one of the key research projects of scientific and technical personnel in this field.

Method used

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  • Cannabidiol CBD nano-emulsion and preparation method thereof
  • Cannabidiol CBD nano-emulsion and preparation method thereof
  • Cannabidiol CBD nano-emulsion and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] A cannabidiol CBD nanoemulsion prepared through the following steps:

[0024] 1) Prepare materials according to the following mass parts:

[0025]

[0026] 2) Put the hemp oil in a 30°C water bath and heat it until the oil temperature reaches 30°C, then add the cannabidiol CBD into the hemp oil, and dissolve the cannabidiol CBD in the oil at a stirring speed of 10r / s , to get oil soluble;

[0027] 3) Freeze the oil-soluble matter in a -80°C liquid nitrogen refrigerator for 1 hour, thaw to room temperature, heat in a 30°C water bath for 20 minutes, and then freeze in a -80°C liquid nitrogen refrigerator for 1 hour, thaw to room temperature, and put Heat in a water bath at 30°C for 20 minutes, and repeat this until the dissolution of cannabidiol CBD reaches its saturation; then add hydrogenated castor oil polyoxyethylene ether-40, hydrogenated castor oil polyoxyethylene ether-20, polyethylene glycol Alcohol-400, stirred at a speed of 10r / s for 15min to obtain a mixtu...

Embodiment 2

[0030] A cannabidiol CBD nanoemulsion prepared through the following steps:

[0031] 1) Prepare materials according to the following mass parts:

[0032]

[0033] 2) First mix hemp oil and grape seed oil evenly, put them in a 67°C water bath and heat until the oil temperature reaches 67°C, then add cannabidiol CBD into the mixed oil, and use it at a stirring speed of 30r / s Cannabidiol CBD is dissolved in mixed oil to obtain oil-soluble products;

[0034] 3) Freeze the oil-soluble substance in a -196°C liquid nitrogen refrigerator for 30 minutes, thaw to room temperature, heat in a 67°C water bath for 10 minutes, and then freeze in a -196°C liquid nitrogen refrigerator for 30 minutes, thaw to room temperature, and put Heat in a water bath at 67°C for 10 minutes, and repeat this until the dissolution of cannabidiol CBD reaches its saturation; then add hydrogenated castor oil polyoxyethylene ether-40, Tween-80, sorbitol liquid, and glycerin in order to Stir at a speed of 40r...

Embodiment 3

[0037] A cannabidiol CBD nanoemulsion prepared through the following steps:

[0038] 1) Prepare materials according to the following mass parts:

[0039]

[0040] 2) Put the lemon oil phase in a 45°C water bath and heat until the oil temperature reaches 45°C, then add the cannabidiol CBD into the oil, and dissolve the cannabidiol CBD in the lemon oil at a stirring speed of 20r / s In, oil soluble matter was obtained;

[0041] 3) Freeze the oil-soluble substance in a -120°C liquid nitrogen refrigerator for 50 minutes, thaw to room temperature, heat in a 40°C water bath for 15 minutes, then freeze in a -120°C liquid nitrogen refrigerator for 50 minutes, thaw to room temperature, and put Heat in a water bath at 40°C for 15 minutes, and repeat this until the dissolution of cannabidiol CBD reaches its saturation; then add Tween-80, hydrogenated castor oil polyoxyethylene ether-20, co-emulsifier, polyethylene glycol -400. Sorbitol liquid, stirred at a speed of 30r / s for 10min to ...

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Abstract

The invention provides a cannabidiol CBD nano-emulsion and a preparation method thereof. The cannabidiol CBD nano-emulsion is prepared from the following raw materials in percentage by mass: 5-10 percent of emulsifier, 2.5-6 percent of co-emulsifier, 1-25 percent of cannabidiol CBD, 1-25 percent of an oil phase and the balance of deionized water. According to the preparation method, the cannabidiol CBD is directly dissolved in the oil phase, and repeated freezing, unfreezing and heating bath are performed to prepare the cannabidiol CBD nano-emulsion. By utilizing the stable performance of the nano-emulsion, the form of the cannabidiol CBD nano-emulsion can be maintained effectively for a long time, the original structure of the cannabidiol CBD can be maintained, the cannabidiol CBD can be furthest absorbed and utilized, and the bioavailability of the cannabidiol CBD can be greatly improved. Furthermore, the cannabidiol CBD nano-emulsion is water soluble, the application range of the cannabidiol CBD nano-emulsion can be enlarged, and reliable technical support is provided to subsequent application, researches and development.

Description

technical field [0001] The invention relates to a nano-emulsion freeze-dried powder, in particular to a cannabidiol (CBD) nano-emulsion freeze-dried powder and a preparation method thereof, belonging to the field of biotechnology. Background technique [0002] Cannabidiol CBD is an ingredient extracted from hemp. Hemp belongs to Magnoliopsida, Urticales, Cannabinaceae, Cannabis, Cannabis sativa L., an annual herb. Studies have shown that cannabidiol CBD has important medicinal value, and has shown good pharmacological activity in the fields of neuroprotection, epilepsy, multiple sclerosis, rheumatoid arthritis, tumors, etc., and has very good application prospects. Not addictive. The currently available cannabidiol CBD is an active ingredient extracted from industrial hemp with a THC content of less than 0.3%, and it does not belong to drugs, precursor chemicals, narcotics, or psychotropic substances in my country and most countries. It has the effects of treating epileps...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/107A61K47/44A61K47/10A61K47/26A61K31/05A61P29/00A61P35/00A61P1/08A61P25/00A61P31/04A61P31/10
CPCA61K9/1075A61K31/05A61K47/10A61K47/26A61K47/44A61P1/08A61P25/00A61P29/00A61P31/04A61P31/10A61P35/00
Inventor 李映波冯红钟化梅孙笠雯罗凡雅
Owner 云南辰锦威生物科技有限公司
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