A kind of preparation method of cyclodextrin microsphere

Abstract

The invention discloses a preparation method of cyclodextrin microspheres: the cyclodextrin is alkalized and then added with a cross-linking agent for pre-cross-linking for a period of time, then the pre-cross-linked product and the oil phase are mixed in a certain proportion, and the reaction is stirred until The pre-crosslinked product becomes microsphere particles; after standing until the microsphere particles in the oil phase are completely precipitated, the upper oil phase is sucked out and recovered, and the obtained microsphere particles are rinsed with distilled water and transferred to absolute ethanol for soaking and washing. Then dry to constant weight to obtain β-cyclodextrin microspheres. Compared with the conventional inverse emulsion polymerization method, the present invention has the following advantages: the preparation steps are simple, the reagents required are few, the oil phase does not need to add emulsifier, and oil-water separation can be directly carried out after the reaction; the subsequent treatment of the obtained microspheres is simple; the oil phase is separated The recovery is more convenient and the recycling rate is higher; the particle size distribution of the obtained microspheres is more in line with the normal distribution and the particle size distribution is more concentrated; the particle size of the microspheres can be easily and effectively controlled during the preparation process, and microspheres with different particle sizes can be obtained. ball.

Description

Technical field: [0001] The invention relates to the field of polymer microspheres, in particular to a preparation method of cyclodextrin microspheres. Background technique: [0002] Cyclodextrin has a special structure with a hydrophilic exterior and a hydrophobic interior. It is an excellent structural unit. Its polymers have been widely used in various fields: catalysis, chiral separation, drug loading and slow release, and adsorption of environmental pollutants. Wait. Cyclodextrin molecules can still retain cavities and hydroxyl groups in the polymer, which provides the possibility for cyclodextrin polymers to include organic and inorganic guest molecules, and people can design and develop different properties and functions according to actual needs. Cyclodextrin polymer material. [0003] Polymer microspheres are a kind of functional polymer materials, which have a variety of excellent properties: uniformity, regularity of structure, large specific surface area and ea...

AI Technical Summary

Problems solved by technology

However, this type of method has cumbersome post-processing: it is necessary to add a demulsifier to demulsify the emulsifier to expose the microspheres; the oil phase obtained after demulsification contains various impurities such as emulsifiers, resulting in a low reuse rate of the oil phase; the obtained The particle size uniformity of the microspheres still needs to be improved

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