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A magnetically enhanced phase-modified medical composite material bone repair bracket and its manufacturing method

A composite material and magnetic enhancement technology, applied in additive processing, medical science, prosthesis, etc., can solve the problems of unsatisfactory structural properties and brittleness of bone repair materials, and achieve good osteoinductive properties, good adsorption properties, and promote The effect of cell adhesion

Active Publication Date: 2021-11-12
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Bulk hydrotalcite compounds have good biocompatibility as bone implant materials, but they are brittle and cannot meet the structural characteristics of bone repair materials

Method used

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  • A magnetically enhanced phase-modified medical composite material bone repair bracket and its manufacturing method

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Experimental program
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Effect test

Embodiment 1

[0034] A magnetic-enhanced phase-modified medical composite material bone repair bracket, with a pore size of 600 μm and a porosity of 80%, includes the following raw materials in terms of weight percentage:

[0035] Magnesium iron bimetallic composite oxide 1%,

[0036] Degradable polymer material polylactic acid 99%.

[0037] in:

[0038] The magnesium-iron bimetallic composite oxide is a roasted product of magnesium-iron hydrotalcite, which maintains the interlayer structure of hydrotalcite compounds, and has a particle size of 500 mesh.

[0039] The degradable polymer material is medical grade polylactic acid with an average molecular weight of 50,000 and a particle size of 2mm.

[0040] Its preparation steps are as follows:

[0041] 1) Preparation of magnesium iron hydrotalcite powder: prepare Mg(NO 3 ) 2 ·6H 2 O and Fe(NO 3 ) 3 9H 2 O blended salt solution containing 0.1mol / L Mg(NO 3 ) 2 and 0.02mol / L Fe(NO 3 ) 3 , and 400rpm magnetic stirring salt solution,...

Embodiment 2

[0046] A magnetic-enhanced phase-modified medical composite material bone repair bracket has a pore diameter of 300 μm and a porosity of 60%, and includes the following raw materials according to weight percentage:

[0047] Magnesium iron bimetallic composite oxide 25%,

[0048] Degradable polymer material polycaprolactone 75%.

[0049] in:

[0050] The magnesium-iron bimetallic composite oxide is a roasted product of magnesium-iron hydrotalcite, which maintains the interlayer structure of hydrotalcite compounds, and has a particle size of 800 mesh.

[0051] The degradable polymer material is medical grade polycaprolactone with an average molecular weight of 500,000 and a particle size of 3 mm.

[0052] Its preparation steps are as follows:

[0053] 1) Preparation of magnesium iron hydrotalcite powder: prepare Mg(NO 3 ) 2 ·6H 2 O and Fe(NO 3 ) 3 9H 2 O blended salt solution containing 0.3mol / L Mg(NO 3 ) 2 and 0.1mol / L Fe(NO 3 ) 3 , and 1000rpm magnetic stirring sa...

Embodiment 3

[0058] A magnetically enhanced phase-modified medical composite material bone repair bracket, the pore diameter is 500 μm, the porosity is 70%, and the following raw materials are included according to weight percentage:

[0059] Magnesium iron bimetallic composite oxide 10%,

[0060] Degradable polymer material polyglycolide 90%.

[0061] in:

[0062] The magnesium-iron bimetal composite oxide is a roasted product of magnesium-iron hydrotalcite, which maintains the interlayer structure of hydrotalcite compounds, and has a particle size of 600 mesh.

[0063] The degradable polymer material is medical grade polyglycolide with an average molecular weight of 300,000 and a particle size of 2.5 mm.

[0064] Its preparation steps are as follows:

[0065] 1) Preparation of magnesium iron hydrotalcite powder: prepare Mg(NO 3 ) 2 ·6H 2 O and Fe(NO 3 ) 3 9H 2 O blended salt solution containing 0.15mol / L Mg(NO 3 ) 2 and 0.04mol / L Fe(NO 3 ) 3 , and 400rpm magnetic stirring sa...

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Abstract

The invention discloses a magnetically enhanced phase-modified medical composite bone repair bracket and a manufacturing method thereof. The bone repair bracket includes the following raw materials according to weight percentage: 1% to 25% of magnesium-iron bimetallic composite oxide, 75% of degradable polymer material %~99%. The preparation method is as follows: 1) preparation of layered magnesium-iron bimetallic composite oxide, 2) blending of magnesium-iron bimetallic composite oxide and biodegradable polymer, 3) filament extrusion of composite material, 4) composite material Bracket print. Based on the concept of composite reinforcement, the present invention adopts 3D printing technology to prepare a biodegradable polymer-based composite material scaffold, and realizes that the layered magnesium-iron bimetallic composite oxide reinforcement phase is evenly distributed in the radial direction in the degradable polymer matrix through magnetic response. The composite material has the advantages of controllable degradation rate, good biocompatibility and excellent mechanical properties, and is suitable for the field of bone repair implant materials.

Description

technical field [0001] The invention relates to a magnetically enhanced phase-modified medical composite material bone repair bracket and a manufacturing method thereof, belonging to the field of biological materials. Background technique [0002] Fractures are the most common clinical trauma in medicine, and most orthopedic procedures require implanted materials for bone filling or bone fixation. Common biodegradable polymer materials include polylactic acid, polycaprolactone, and polyglycolide; taking polylactic acid as an example, polylactic acid has good degradability and biosafety, and is recognized by the US FDA as a biodegradable material , can avoid the pain and economic burden of secondary surgery on patients, and is expected to replace traditional bioinert materials. However, polylactic acid has some shortcomings as an implant material for bone repair, including: (1) the acidic physiological microenvironment is caused during the degradation process, which hinders ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/44A61L27/50A61L27/56A61L27/58B33Y70/10B33Y80/00
CPCA61L27/446A61L27/50A61L27/56A61L27/58A61L2430/02B33Y70/00B33Y80/00C08L67/04
Inventor 白晶董强胜周星星程兆俊张越薛烽储成林
Owner SOUTHEAST UNIV
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