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Method for preparing nanoemulsion by using supergravity technology

A nano-emulsion and supergravity technology, which is applied in the fields of food, cosmetics and biomedicine, can solve the problems of uneven droplets and complicated operation, and achieve the effects of simple process, low dosage and high efficiency.

Active Publication Date: 2019-11-01
BEIJING UNIV OF CHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the method is complicated to operate and the obtained droplets are not uniform

Method used

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  • Method for preparing nanoemulsion by using supergravity technology
  • Method for preparing nanoemulsion by using supergravity technology

Examples

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Effect test

Embodiment 1

[0041] A method for preparing nanoemulsions by using high gravity technology, comprising the steps of:

[0042] Mix 10g glycerol triacetate, 3g polyoxyethylene hydrogenated castor oil, and 1.5g 1,2-propanediol by vortexing completely, turn on the high-gravity rotating bed at a speed of 500rpm, and feed the mixed solution at 20ml / min and the aqueous solution at 200ml / min. The temperature of the system is controlled at 25° C., and after the feeding of the mixed solution is completed, the high-gravity rotating bed is closed to obtain a nanoemulsion.

[0043] The consumption of surfactant accounts for 4% of nanoemulsion total amount in the nanoemulsion that present embodiment makes;

[0044] The appearance of the nanoemulsion prepared in this example is clear and transparent, the average particle size is 15nm; the PDI value of the particle size distribution coefficient is 0.069, indicating that an emulsion with uniform size is obtained. After testing, it was found that after stor...

Embodiment 2

[0050] A method for preparing nanoemulsions by using high gravity technology, comprising the steps of:

[0051] Mix 10g glycerol triacetate, 0.3g polyoxyethylene hydrogenated castor oil, and 0.15g 1,2-propanediol by vortexing completely, turn on the high-gravity rotating bed at a speed of 500rpm, mix the solution at 20ml / min, and the aqueous solution at 200ml / min For feeding, the temperature of the system is controlled at 25° C., and after the feeding of the mixed solution is completed, the high-gravity rotating bed is closed to obtain a nanoemulsion.

[0052] The consumption of surfactant accounts for 0.4% of the nanoemulsion total amount in the nanoemulsion that present embodiment makes;

[0053] The appearance of the nanoemulsion prepared in this example is clear and transparent, the average particle size is 15 nm, and the PDI value of the particle size distribution coefficient is 0.069, indicating that an emulsion with uniform size is obtained. After a long-term stability...

Embodiment 3

[0059] A method for preparing nanoemulsions by using high gravity technology, comprising the steps of:

[0060] Mix 10g of soybean oil, 4g of polyoxyethylene hydrogenated castor oil, and 2g of anhydrous ethanol by vortex shaking, turn on the high-gravity rotating bed at a speed of 1000rpm, feed the mixed solution at 30ml / min, and the aqueous solution at 300ml / min, and control the system The temperature is 25° C., and after the feeding of the mixed solution is completed, the high-gravity rotating bed is closed to obtain a nanoemulsion.

[0061] The consumption of surfactant accounts for 5% of nanoemulsion total amount in the nanoemulsion that present embodiment makes;

[0062] The appearance of the nanoemulsion prepared in this example is clear and transparent, the average particle size is 25nm, and the PDI value of the particle size distribution coefficient is 0.088, indicating that an emulsion with uniform size is obtained. After a long-term stability test, it was found that...

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Abstract

The invention discloses a method for preparing a nanoemulsion by using a supergravity technology. The method comprises the steps of mixing an oil phase and water in a high-gravity rotating bed to obtain a nanoemulsion, and comprises following specific steps: S1) mixing the oil phase, a surfactant and a co-surfactant to obtain a mixed solution; S2) mixing the mixed solution and water in the high-gravity rotating bed to obtain the nanoemulsion. The nanoemulsion prepared by the method has a particle size range of 10-50 nm and a particle size distribution coefficient PDI value of <=0.2, and has noobvious change in the appearance and particle size after room-temperature storage for 180 days or longer. The dosage of the surfactant is low, toxic and side effects are reduced, and the mass transfer performance of the high-gravity rotating bed substitutes the use of a large amount of the surfactant to obtain the greener and safer nanoemulsion. The method has the advantages of a simple process,easy realization, low energy consumption, a high efficiency, a low cost and easy scale-up and can achieve a goal of industrial production.

Description

technical field [0001] The invention relates to the technical fields of biomedicine, food and cosmetics, in particular to a method for preparing nanoemulsions by applying the supergravity technology. Background technique [0002] Nanoemulsion, also known as microemulsion, was first discovered and reported by Hoar and Schulman in 1943. It was not until 1959 that Schulman proposed the concept of "microemulsion". Since then, the theoretical and applied research on nanoemulsions has developed rapidly. Nanoemulsion is a transparent or translucent dispersion composed of oil phase, water phase, surfactant and co-surfactant, and its particle size distribution is between 1-500nm. The nanoemulsion is convenient to prepare, has high safety and is favorable for absorption. In terms of medical treatment, it can increase the solubility of poorly water-soluble drugs, improve the stability and bioavailability of drugs, and at the same time, because of its special structural composition, i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01F3/08
CPCB01F23/4105B01F23/4143
Inventor 乐园武浩然吴凯陈鹏
Owner BEIJING UNIV OF CHEM TECH
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