Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

A method for preparing nanoemulsions using supergravity technology

A nanoemulsion and supergravity technology, which is applied in the fields of food, cosmetics and biomedicine, can solve problems such as uneven droplets and complicated operations, and achieve the effects of simple process, low dosage, and reduced toxic and side effects

Active Publication Date: 2021-03-26
BEIJING UNIV OF CHEM TECH
View PDF13 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the method is complicated to operate and the obtained droplets are not uniform

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A method for preparing nanoemulsions using supergravity technology
  • A method for preparing nanoemulsions using supergravity technology

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] A method for preparing nanoemulsions by using high gravity technology, comprising the steps of:

[0042] Mix 10g glycerol triacetate, 3g polyoxyethylene hydrogenated castor oil, and 1.5g 1,2-propanediol by vortexing completely, turn on the high-gravity rotating bed at a speed of 500rpm, and feed the mixed solution at 20ml / min and the aqueous solution at 200ml / min. The temperature of the system is controlled at 25° C., and after the feeding of the mixed solution is completed, the high-gravity rotating bed is closed to obtain a nanoemulsion.

[0043] The consumption of surfactant accounts for 4% of nanoemulsion total amount in the nanoemulsion that present embodiment makes;

[0044] The appearance of the nanoemulsion prepared in this example is clear and transparent, the average particle size is 15nm; the PDI value of the particle size distribution coefficient is 0.069, indicating that an emulsion with uniform size is obtained. After testing, it was found that after stor...

Embodiment 2

[0050] A method for preparing nanoemulsions by using high gravity technology, comprising the steps of:

[0051] Mix 10g glycerol triacetate, 0.3g polyoxyethylene hydrogenated castor oil, and 0.15g 1,2-propanediol by vortexing completely, turn on the high-gravity rotating bed at a speed of 500rpm, mix the solution at 20ml / min, and the aqueous solution at 200ml / min For feeding, the temperature of the system is controlled at 25° C., and after the feeding of the mixed solution is completed, the high-gravity rotating bed is closed to obtain a nanoemulsion.

[0052] The consumption of surfactant accounts for 0.4% of the nanoemulsion total amount in the nanoemulsion that present embodiment makes;

[0053] The appearance of the nanoemulsion prepared in this example is clear and transparent, the average particle size is 15 nm, and the PDI value of the particle size distribution coefficient is 0.069, indicating that an emulsion with uniform size is obtained. After a long-term stability...

Embodiment 3

[0059] A method for preparing nanoemulsions by using high gravity technology, comprising the steps of:

[0060] Mix 10g of soybean oil, 4g of polyoxyethylene hydrogenated castor oil, and 2g of anhydrous ethanol by vortex shaking, turn on the high-gravity rotating bed at a speed of 1000rpm, feed the mixed solution at 30ml / min, and the aqueous solution at 300ml / min, and control the system The temperature is 25° C., and after the feeding of the mixed solution is completed, the high-gravity rotating bed is closed to obtain a nanoemulsion.

[0061] The consumption of surfactant accounts for 5% of nanoemulsion total amount in the nanoemulsion that present embodiment makes;

[0062] The appearance of the nanoemulsion prepared in this example is clear and transparent, the average particle size is 25nm, and the PDI value of the particle size distribution coefficient is 0.088, indicating that an emulsion with uniform size is obtained. After a long-term stability test, it was found that...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
particle diameteraaaaaaaaaa
particle diameteraaaaaaaaaa
particle diameteraaaaaaaaaa
Login to View More

Abstract

The invention discloses a method for preparing a nanoemulsion by applying high gravity technology, the method comprises the step of mixing an oil phase and water in a high gravity rotating bed to obtain a nanoemulsion; including the following specific steps: S1, mixing the oil phase, surface active Agent and co-surfactant are mixed to obtain a mixed solution; S2, the mixed solution and water are mixed in a high-gravity rotating bed to obtain a nanoemulsion. By the method of the present invention, the prepared nanoemulsion particle size range is 10-50nm, the particle size distribution coefficient PDI value≦0.2, and there is no obvious change in appearance and particle size under normal temperature conditions for ≧180 days; the surfactant of the present invention The dosage is small, the toxic and side effects are reduced, and the use of a large amount of surfactants is replaced by the mass transfer performance of the high-gravity rotating bed to obtain a greener and safer nanoemulsion; the process of the invention is simple, easy to realize, low energy consumption, high efficiency, and low cost. Low, and very easy to scale up, to achieve the invention goal of industrial production.

Description

technical field [0001] The invention relates to the technical fields of biomedicine, food and cosmetics, in particular to a method for preparing nanoemulsions by applying the supergravity technology. Background technique [0002] Nanoemulsion, also known as microemulsion, was first discovered and reported by Hoar and Schulman in 1943. It was not until 1959 that Schulman proposed the concept of "microemulsion". Since then, the theoretical and applied research on nanoemulsions has developed rapidly. Nanoemulsion is a transparent or translucent dispersion composed of oil phase, water phase, surfactant and co-surfactant, and its particle size distribution is between 1-500nm. The nanoemulsion is convenient to prepare, has high safety and is favorable for absorption. In terms of medical treatment, it can increase the solubility of poorly water-soluble drugs, improve the stability and bioavailability of drugs, and at the same time, because of its special structural composition, i...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): B01F3/08
CPCB01F23/4105B01F23/4143
Inventor 乐园武浩然吴凯陈鹏
Owner BEIJING UNIV OF CHEM TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com